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The 3D characterization of microstructures is crucial for understanding and designing functional materials. However, the scanning electron microscope (SEM), widely used in scientific research, captures only 2D electron intensity…

Image and Video Processing · Electrical Eng. & Systems 2026-04-06 Shuo Chen , Yijin Li , Xi Zheng , Guofeng Zhang

We demonstrate a multi-beam scanning transmission electron microscopy (STEM) imaging that integrates down-sampling with super-resolution image reconstruction via a compressive sensing framework. A custom condenser aperture with six randomly…

Instrumentation and Detectors · Physics 2026-03-19 Akira Yasuhara , Takumi Sannomiya , Ryoichi Horisaki

The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information. Using X-ray crystallography and, more recently, cryo-electron microscopy (cryo-EM),…

Biological Physics · Physics 2017-11-17 Lars V. Bock , Michal H. Kolář , Helmut Grubmüller

The living body is composed of innumerable fine and complex structures and although these structures have been studied in the past, a vast amount of information pertaining to them still remains unknown. When attempting to observe these…

Medical Physics · Physics 2021-11-30 Raku Son , Kenji Yamazawa , Akiko Oguchi , Mitsuo Suga , Masaru Tamura , Yasuhiro Murakawa , Satoshi Kume

The maximum entropy method (MEM) is a well known deconvolution technique in radio-interferometry. This method solves a non-linear optimization problem with an entropy regularization term. Other heuristics such as CLEAN are faster but highly…

Instrumentation and Methods for Astrophysics · Physics 2022-10-27 M. Cárcamo , P. Román , S. Casassus , V. Moral , F. R. Rannou

Cryo-electron tomography enables 3D visualization of cells in a near native state at molecular resolution. The produced cellular tomograms contain detailed information about all macromolecular complexes, their structures, their abundances…

Quantitative Methods · Quantitative Biology 2019-04-30 Min Xu , Elitza I Tocheva , Yi-Wei Chang , Grant J Jensen , Frank Alber

The reconstruction of images from a small number of projections using the maximum-entropy method (MEM) with the Shannon entropy is considered. MEM provides higher-quality image reconstruction for sources with extended components than the…

Astrophysics · Physics 2008-11-26 Anisa T. Bajkova

Properties of crystalline materials are closely linked to microstructure arising from the spatial arrangement, orientation, and phase of nanocrystals. Rapid characterization of crystalline microstructure can accelerate the identification of…

Materials Science · Physics 2026-02-16 Kwanghwi Je , Ellis R. Kennedy , Sungin Kim , Yao Yang , Erik H. Thiede

Reconstruction of the exit wave function is an important route to interpreting high-resolution transmission electron microscopy (HRTEM) images. Here we demonstrate that convolutional neural networks can be used to reconstruct the exit wave…

Inspired by biology's most sophisticated computer, the brain, neural networks constitute a profound reformulation of computational principles. Remarkably, analogous high-dimensional, highly-interconnected computational architectures also…

Disordered Systems and Neural Networks · Physics 2024-01-23 Constantine Glen Evans , Jackson O'Brien , Erik Winfree , Arvind Murugan

Deep learning based techniques achieve state-of-the-art results in a wide range of image reconstruction tasks like compressed sensing. These methods almost always have hyperparameters, such as the weight coefficients that balance the…

Computer Vision and Pattern Recognition · Computer Science 2022-06-10 Alan Q. Wang , Adrian V. Dalca , Mert R. Sabuncu

In collider experiments, the kinematic reconstruction of heavy, short-lived particles is vital for precision tests of the Standard Model and in searches for physics beyond it. Performing kinematic reconstruction in collider events with many…

High Energy Physics - Phenomenology · Physics 2025-02-13 Callum Birch-Sykes , Brian Le , Yvonne Peters , Ethan Simpson , Zihan Zhang

We present a simple but novel hybrid approach to hyperspectral data cube reconstruction from computed tomography imaging spectrometry (CTIS) images that sequentially combines neural networks and the iterative Expectation Maximization (EM)…

Image and Video Processing · Electrical Eng. & Systems 2022-12-20 Mads J. Ahlebæk , Mads S. Peters , Wei-Chih Huang , Mads T. Frandsen , René L. Eriksen , Bjarke Jørgensen

The sparse interferometric coverage of the Event Horizon Telescope (EHT) poses a significant challenge for both reconstruction and model fitting of black-hole images. PRIMO is a new principal components analysis-based algorithm for image…

High Energy Astrophysical Phenomena · Physics 2023-02-15 Lia Medeiros , Dimitrios Psaltis , Tod R. Lauer , Feryal Ozel

Host-guest interactions govern the chemistry of a broad range of functional materials. However, the weak bonding between host and guest prevents atomic-resolution studies of their structure and chemistry using transmission electron…

Monocular dense 3D reconstruction of deformable objects is a hard ill-posed problem in computer vision. Current techniques either require dense correspondences and rely on motion and deformation cues, or assume a highly accurate…

Computer Vision and Pattern Recognition · Computer Science 2019-08-07 Vladislav Golyanik , Soshi Shimada , Kiran Varanasi , Didier Stricker

Traditional sampling schemes often assume that the sampling locations are known. Motivated by the recent bioimaging technique known as cryogenic electron microscopy (cryoEM), we consider the problem of reconstructing an unknown 3D structure…

Signal Processing · Electrical Eng. & Systems 2024-04-16 Renke Wang , Francien G. Bossema , Thierry Blu , Pier Luigi Dragotti

We describe a new generation of algorithms capable of mapping the structure and conformations of macromolecules and their complexes from large ensembles of heterogeneous snapshots, and demonstrate the feasibility of determining both…

Biological Physics · Physics 2014-04-30 P. Schwander , R. Fung , A. Ourmazd

Determining the structure of a protein has been a decades-long open question. A protein's three-dimensional structure often poses nontrivial computation costs, when classical simulation algorithms are utilized. Advances in the transformer…

Machine Learning · Computer Science 2023-10-09 Chen Dun , Qiutai Pan , Shikai Jin , Ria Stevens , Mitchell D. Miller , George N. Phillips, , Anastasios Kyrillidis

Quantitative microstructural characterization is fundamental to materials science, where electron micrograph (EM) provides indispensable high-resolution insights. However, progress in deep learning-based EM characterization has been…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Nan wang , Zhiyi Xia , Yiming Li , Shi Tang , Zuxin Fan , Xi Fang , Haoyi Tao , Xiaochen Cai , Guolin Ke , Linfeng Zhang , Yanhui Hong
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