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Deep learning has been recently used for the analysis of neuroimages, such as structural magnetic resonance imaging (MRI), functional MRI, and positron emission tomography (PET), and has achieved significant performance improvements over…

Image and Video Processing · Electrical Eng. & Systems 2020-05-12 Li Zhang , Mingliang Wang , Mingxia Liu , Daoqiang Zhang

Large pre-trained models with their numerous model parameters and extensive training datasets have shown excellent performance in various tasks. Many publicly available medical image datasets do not have a sufficient amount of data so there…

Image and Video Processing · Electrical Eng. & Systems 2024-03-12 Jianhao Xie , Ziang Zhang , Guibo Luo , Yuesheng Zhu

Alzheimer's disease is characterised by the spreading of misfolded proteins and progressive structural changes in the brain. Despite significant clinical research, understanding how microscopic protein dynamics translate into macroscopic…

Computational Engineering, Finance, and Science · Computer Science 2026-03-23 A. Vazquez-Palomo , C. Betegón , J. Weickenmeier , E. Martínez-Pañeda

Using massive datasets, foundation models are large-scale, pre-trained models that perform a wide range of tasks. These models have shown consistently improved results with the introduction of new methods. It is crucial to analyze how these…

Image and Video Processing · Electrical Eng. & Systems 2025-05-27 Mobina Mansoori , Sajjad Shahabodini , Farnoush Bayatmakou , Jamshid Abouei , Konstantinos N. Plataniotis , Arash Mohammadi

While foundation models have achieved remarkable results across a diversity of domains, they still rely on human-generated data, such as text, as a fundamental source of knowledge. However, this data is ultimately the product of human…

Neurons and Cognition · Quantitative Biology 2026-01-21 Maël Donoso

Neurodegenerative diseases and traumatic brain injuries (TBI) are among the main causes of cognitive dysfunction in humans. Both manifestations exhibit the extensive presence of focal axonal swellings (FAS). FAS compromises the information…

Neurons and Cognition · Quantitative Biology 2016-09-27 Melanie Weber , Pedro D. Maia , J. Nathan Kutz

Paediatric Acute Myeloid Leukemia is a complex adaptive ecosystem with high morbidity. Current trajectory inference algorithms struggle to predict causal dynamics in AML progression, including relapse and recurrence risk. We propose a…

Quantitative Methods · Quantitative Biology 2025-08-20 Abicumaran Uthamacumaran , Hector Zenil

The pervasive uncertainty and dynamic nature of real-world environments present significant challenges for the widespread implementation of machine-driven Intelligent Decision-Making (IDM) systems. Consequently, IDM should possess the…

Artificial Intelligence · Computer Science 2023-05-17 Ying Wen , Ziyu Wan , Ming Zhou , Shufang Hou , Zhe Cao , Chenyang Le , Jingxiao Chen , Zheng Tian , Weinan Zhang , Jun Wang

Foundation models in digital pathology use massive datasets to learn useful compact feature representations of complex histology images. However, there is limited transparency into what drives the correlation between dataset size and…

Current foundation models for electroencephalography (EEG) rely on architectures adapted from computer vision or natural language processing, typically treating neural signals as pixel grids or token sequences. This approach overlooks that…

Signal Processing · Electrical Eng. & Systems 2026-03-05 Zhisheng Chen , Yingwei Zhang , Qizhen Lan , Tianyu Liu , Huacan Wang , Yi Ding , Ziyu Jia , Ronghao Chen , Kun Wang , Xinliang Zhou

AI-assisted radiological interpretation is based on predominantly narrow, single-task models. This approach is impractical for covering the vast spectrum of imaging modalities, diseases, and radiological findings. Foundation models (FMs)…

Healthcare data now span EHRs, medical imaging, genomics, and wearable sensors, but most diagnostic models still process these modalities in isolation. This limits their ability to capture early, cross-modal disease signatures. This paper…

Machine Learning · Computer Science 2025-12-18 Md Talha Mohsin , Ismail Abdulrashid

Unveiling pathological brain changes associated with Alzheimer's disease (AD) is a challenging task especially that people do not show symptoms of dementia until it is late. Over the past years, neuroimaging techniques paved the way for…

Quantitative Methods · Quantitative Biology 2018-08-07 Mayssa Soussia , Islem Rekik

Dementia is a collection of symptoms associated with impaired cognition and impedes everyday normal functioning. Dementia, with Alzheimer's disease constituting its most common type, is highly complex in terms of etiology and…

Foundation models show strong potential for large-scale, high-dimensional biomedical applications, yet their ability to capture relevant neurobiological characteristics remains underexplored. We systematically evaluate embeddings from two…

Signal Processing · Electrical Eng. & Systems 2026-04-17 Ye Tao , Bradley T. Baker , Yu Wu , Anand D. Sarwate , Sandeep Panta , Sergey Plis , Vince D. Calhoun

Artificial intelligence (AI) has emerged as a pivotal enabler for next-generation wireless communication systems. However, conventional AI-based models encounter several limitations, such as heavy reliance on labeled data, limited…

Signal Processing · Electrical Eng. & Systems 2025-10-14 Jun Jiang , Yuan Gao , Xinyi Wu , Shugong Xu

Computer-aided diagnosis for medical imaging is a well-studied field that aims to provide real-time decision support systems for physicians. These systems attempt to detect and diagnose a plethora of medical conditions across a variety of…

Artificial Intelligence · Computer Science 2022-05-25 Glen Smith , Qiao Zhang , Christopher MacLellan

The segmentation of substantial brain lesions is a significant and challenging task in the field of medical image segmentation. Substantial brain lesions in brain imaging exhibit high heterogeneity, with indistinct boundaries between lesion…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Hongming Wang , Yifeng Wu , Huimin Huang , Hongtao Wu , Jia-Xuan Jiang , Xiaodong Zhang , Hao Zheng , Xian Wu , Yefeng Zheng , Jinping Xu , Jing Cheng

Alzheimer's Disease and normal aging are both characterized by brain atrophy. The question of whether AD-related brain atrophy represents accelerated aging or a neurodegeneration process distinct from that in normal aging remains…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Jingru Fu , Daniel Ferreira , Örjan Smedby , Rodrigo Moreno

Alzheimer's disease (AD) is an irreversible brain disease that can dramatically reduce quality of life, most commonly manifesting in older adults and eventually leading to the need for full-time care. Early detection is fundamental to…

Computation and Language · Computer Science 2019-06-14 Flavio Di Palo , Natalie Parde
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