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Supervised deep learning methods have achieved considerable success in medical image analysis, owing to the availability of large-scale and well-annotated datasets. However, creating such datasets for whole slide images (WSIs) in…

Computer Vision and Pattern Recognition · Computer Science 2024-06-10 Hao Wang , Euijoon Ahn , Jinman Kim

Using deep learning models to diagnose cancer from histology data presents several challenges. Cancer grading and localization of regions of interest (ROIs) in these images normally relies on both image- and pixel-level labels, the latter…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Jérôme Rony , Soufiane Belharbi , Jose Dolz , Ismail Ben Ayed , Luke McCaffrey , Eric Granger

Weakly Supervised Anomaly detection (WSAD) in brain MRI scans is an important challenge useful to obtain quick and accurate detection of brain anomalies when precise pixel-level anomaly annotations are unavailable and only weak labels…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Bheeshm Sharma , Karthikeyan Jaganathan , Balamurugan Palaniappan

The recent state-of-the-art deep learning methods have significantly improved brain tumor segmentation. However, fully supervised training requires a large amount of manually labeled masks, which is highly time-consuming and needs domain…

Image and Video Processing · Electrical Eng. & Systems 2019-11-07 Zhanghexuan Ji , Yan Shen , Chunwei Ma , Mingchen Gao

Malignant brain tumors have become an aggressive and dangerous disease that leads to death worldwide.Multi-modal MRI data is crucial for accurate brain tumor segmentation, but missing modalities common in clinical practice can severely…

Methodology · Statistics 2025-07-11 Guoyan Liang , Qin Zhou , Jingyuan Chen , Bingcang Huang , Kai Chen , Lin Gu , Zhe Wang , Sai Wu , Chang Yao

Consistency learning plays a crucial role in semi-supervised medical image segmentation as it enables the effective utilization of limited annotated data while leveraging the abundance of unannotated data. The effectiveness and efficiency…

Computer Vision and Pattern Recognition · Computer Science 2023-05-26 Zhenxi Zhang , Ran Ran , Chunna Tian , Heng Zhou , Xin Li , Fan Yang , Zhicheng Jiao

Instance segmentation is a fundamental research in computer vision, especially in autonomous driving. However, manual mask annotation for instance segmentation is quite time-consuming and costly. To address this problem, some prior works…

Computer Vision and Pattern Recognition · Computer Science 2023-12-19 Guangfeng Jiang , Jun Liu , Yuzhi Wu , Wenlong Liao , Tao He , Pai Peng

Cross-domain Few-shot Segmentation (CD-FSS) aims to segment novel classes from target domains that are not involved in training and have significantly different data distributions from the source domain, using only a few annotated samples,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Sujun Sun , Haowen Gu , Cheng Xie , Yanxu Ren , Mingwu Ren , Haofeng Zhang

Pathology is essential for cancer diagnosis, with multiple instance learning (MIL) widely used for whole slide image (WSI) analysis. WSIs exhibit a natural hierarchy -- patches, regions, and slides -- with distinct semantic associations.…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Peixiang Huang , Yanyan Huang , Weiqin Zhao , Junjun He , Lequan Yu

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Linhao Qu , Dingkang Yang , Dan Huang , Qinhao Guo , Rongkui Luo , Shaoting Zhang , Xiaosong Wang

Weakly Supervised Semantic Segmentation (WSSS) is a challenging problem that has been extensively studied in recent years. Traditional approaches often rely on external modules like Class Activation Maps to highlight regions of interest and…

Computer Vision and Pattern Recognition · Computer Science 2025-07-10 Joelle Hanna , Damian Borth

Accurate nuclei segmentation in microscopy whole slide images (WSIs) remains challenging due to variability in staining, imaging conditions, and tissue morphology. We propose CellGenNet, a knowledge distillation framework for robust…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Srijan Ray , Bikesh K. Nirala , Jason T. Yustein , Sundaresh Ram

We propose a novel scalable end-to-end pipeline that uses symbolic domain knowledge as constraints for learning a neural network for classifying unlabeled data in a weak-supervised manner. Our approach is particularly well-suited for…

Machine Learning · Computer Science 2023-10-23 Sudhir Agarwal , Anu Sreepathy , Lalla Mouatadid

Data-driven methods have shown tremendous progress in medical image analysis. In this context, deep learning-based supervised methods are widely popular. However, they require a large amount of training data and face issues in…

Computer Vision and Pattern Recognition · Computer Science 2023-06-02 Ziang Xu , Jens Rittscher , Sharib Ali

Federated learning (FL) effectively mitigates the data silo challenge brought about by policies and privacy concerns, implicitly harnessing more data for deep model training. However, traditional centralized FL models grapple with diverse…

Computer Vision and Pattern Recognition · Computer Science 2024-06-03 Li Lin , Yixiang Liu , Jiewei Wu , Pujin Cheng , Zhiyuan Cai , Kenneth K. Y. Wong , Xiaoying Tang

Self-supervised learning (SSL) has emerged as a powerful strategy for representation learning under limited annotation regimes, yet its effectiveness remains highly sensitive to many factors, especially the nature of the target task. In…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Jorge Quesada , Ghassan AlRegib

Most of the recent Deep Semantic Segmentation algorithms suffer from large generalization errors, even when powerful hierarchical representation models based on convolutional neural networks have been employed. This could be attributed to…

Computer Vision and Pattern Recognition · Computer Science 2019-10-01 Javed Iqbal , Mohsen Ali

Currently, existing efforts in Weakly Supervised Semantic Segmentation (WSSS) based on Convolutional Neural Networks (CNNs) have predominantly focused on enhancing the multi-label classification network stage, with limited attention given…

Computer Vision and Pattern Recognition · Computer Science 2023-10-25 Jia Zhang , Bo Peng , Xi Wu

Labelling tissue components in histology whole slide images (WSIs) is prohibitively labour-intensive: a single slide may contain tens of thousands of structures--cells, nuclei, and other morphologically distinct objects--each requiring…

Quantitative Methods · Quantitative Biology 2026-04-13 Muhammad Haseeb Ahmad , Sharmila Rajendran , Damion Young , Jon Mason

Efficiently training accurate deep models for weakly supervised semantic segmentation (WSSS) with image-level labels is challenging and important. Recently, end-to-end WSSS methods have become the focus of research due to their high…

Computer Vision and Pattern Recognition · Computer Science 2023-02-28 Rongtao Xu , Changwei Wang , Jiaxi Sun , Shibiao Xu , Weiliang Meng , Xiaopeng Zhang