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Non-von Neumann computational hardware, based on neuron-inspired, non-linear elements connected via linear, weighted synapses -- so-called neuromorphic systems -- is a viable computational substrate. Since neuromorphic systems have been…

Neurons and Cognition · Quantitative Biology 2021-03-17 Oleksandr Iaroshenko , Andrew T. Sornborger

Throughout evolution the brain has mastered the art of processing real-world inputs through networks of interlinked spiking neurons. Synapses have emerged as key elements that, owing to their plasticity, are merging neuron-to-neuron…

Computational models have become an essential part of exploratory protocols in cell biology, as a complement to in vivo or in vitro experiments. These virtual models have the twofold advantage of enabling access to new types of data and…

Medical Physics · Physics 2021-12-20 Maxime Vassaux , Laurent Pieuchot , Karine Anselme , Maxence Bigerelle , Jean-Louis Milan

Physical implementations of neural computation now extend far beyond silicon hardware, encompassing substrates such as memristive devices, photonic circuits, mechanical metamaterials, microfluidic networks, chemical reaction systems, and…

Neural and Evolutionary Computing · Computer Science 2026-05-29 Stefan Fischer , Nihat Ay , Olaf Landsiedel , Esfandiar Mohammadi , Sebastian Otte , Bernd-Christian Renner , Nele Rußwinkel

Neuromorphic computing --- brainlike computing in hardware --- typically requires myriad CMOS spiking neurons interconnected by a dense mesh of nanoscale plastic synapses. Memristors are frequently citepd as strong synapse candidates due to…

Neural and Evolutionary Computing · Computer Science 2015-09-02 David Howard , Larry Bull , Ben De Lacy Costello

The brain's remarkable and efficient information processing capability is driving research into brain-inspired (neuromorphic) computing paradigms. Artificial aqueous ion channels are emerging as an exciting platform for neuromorphic…

Soft Condensed Matter · Physics 2024-04-26 T. M. Kamsma , J. Kim , K. Kim , W. Q. Boon , C. Spitoni , J. Park , R. van Roij

The design of intelligent materials often draws parallels with the complex adaptive behaviors of biological organisms, where robust functionality stems from sophisticated hierarchical organization and emergent long-distance coordination…

Soft Condensed Matter · Physics 2025-11-13 Vladimir A. Baulin , Rudolf M. Füchslin , Achille Giacometti , Helmut Hauser , Marco Werner

Metal halide perovskite-based materials have emerged over the past few decades as remarkable solution-processable opto-electronic materials with many intriguing properties and potential applications. These emerging materials have recently…

Applied Physics · Physics 2023-03-07 Gaurav Vats , Brett Hodges , Andrew J. Ferguson , Lance Wheeler , Jeffrey L. Blackburn

Memristors are emerging as key electronic components that retain resistance states without power. Their non-volatile nature and ability to mimic synaptic behavior make them ideal for next-generation memory technologies and neuromorphic…

Mesoscale and Nanoscale Physics · Physics 2025-10-28 Tongxin Chen , Yinyu Nie , Yafei Hao , Shengchun Shen , Jiajun Pan , Xiaoguang Li , Yuan Lu

Organic neuromorphic device networks can accelerate neural network algorithms and directly integrate with microfluidic systems or living tissues. Proposed devices based on the bio-compatible conductive polymer PEDOT:PSS have shown high…

Emerging Technologies · Computer Science 2022-12-12 Daniel Felder , Katerina Muche , John Linkhorst , Matthias Wessling

Modern AI systems, based on von Neumann architecture and classical neural networks, have a number of fundamental limitations in comparison with the brain. This article discusses such limitations and the ways they can be mitigated. Next, it…

Neural and Evolutionary Computing · Computer Science 2022-05-27 Dmitry Ivanov , Aleksandr Chezhegov , Andrey Grunin , Mikhail Kiselev , Denis Larionov

Emergent nanoscale non-volatile memory technologies with high integration density offer a promising solution to overcome the scalability limitations of CMOS-based neural networks architectures, by efficiently exhibiting the key principle of…

Hardware Architecture · Computer Science 2018-11-14 Saber Moradi , Rajit Manohar

Fully CMOS-compatible photonic memory holding devices hold a potential in a development of ultrafast artificial neural networks. Leveraging the benefits of photonics such as high-bandwidth, low latencies, low-energy interconnect and high…

Optics · Physics 2023-08-02 Jacek Gosciniak , Jacob B. Khurgin

Despite their potential to address crucial bottlenecks in computing architectures and contribute to the pool of biological inspiration for engineering, pathological biological mechanisms remain absent from computational theory. We hereby…

Neural and Evolutionary Computing · Computer Science 2025-03-18 Rosalia Moreddu , Michael Levin

Neuromorphic computing which aims to mimic the collective and emergent behavior of the brain's neurons, synapses, axons, dendrites offers an intriguing, potentially disruptive solution to society's ever-growing computational needs. Although…

Applied Physics · Physics 2021-08-31 Uday S. Goteti , Ivan A. Zaluzhnyy , Shriram Ramanathan , Robert C. Dynes , Alex Frano

One major criticism of deep learning centers around the biological implausibility of the credit assignment schema used for learning -- backpropagation of errors. This implausibility translates into practical limitations, spanning scientific…

Neural and Evolutionary Computing · Computer Science 2024-03-29 Alexander Ororbia , Ankur Mali , Adam Kohan , Beren Millidge , Tommaso Salvatori

Sophisticated machine learning struggles to transition onto battery-operated devices due to the high-power consumption of neural networks. Researchers have turned to neuromorphic engineering, inspired by biological neural networks, for more…

Neural and Evolutionary Computing · Computer Science 2023-11-23 Daniel John Mannion

Neuromorphic architectures mimicking biological neural networks have been proposed as a much more efficient alternative to conventional von Neumann architectures for the exploding compute demands of AI workloads. Recent neuroscience theory…

Hardware Architecture · Computer Science 2024-05-21 Harideep Nair , William Leyman , Agastya Sampath , Quinn Jacobson , John Paul Shen

Neuromorphic computing is at the basis of the recent progress in artificial intelligence. But the progress is accompanied with increasing demands in computational resources and power supply. Reservoir neuromorphic computing uses a…

Mesoscale and Nanoscale Physics · Physics 2025-12-01 Teng Long , Yibo Deng , Xuekai Ma , Chunling Gu , Guillaume Malpuech , Qing Liao , Hongbing Fu , Dmitry Solnyshkov