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In recent years, machine learning has been proposed as a promising strategy to build accurate scoring functions for computational docking finalized to numerically empowered drug discovery. However, the latest studies have suggested that…

Quantitative Methods · Quantitative Biology 2023-02-17 F. Pellicani , D. Dal Ben , A. Perali , S. Pilati

To build general-purpose artificial intelligence systems that can deal with unknown variables across unknown domains, we need benchmarks that measure how well these systems perform on tasks they have never seen before. A prerequisite for…

Artificial Intelligence · Computer Science 2022-05-25 Gautham Venkatasubramanian , Sibesh Kar , Abhimanyu Singh , Shubham Mishra , Dushyant Yadav , Shreyansh Chandak

Generalization error predictors (GEPs) aim to predict model performance on unseen distributions by deriving dataset-level error estimates from sample-level scores. However, GEPs often utilize disparate mechanisms (e.g., regressors,…

Machine Learning · Computer Science 2023-05-30 Puja Trivedi , Danai Koutra , Jayaraman J. Thiagarajan

How well do neural networks generalize? Even for grammar induction tasks, where the target generalization is fully known, previous works have left the question open, testing very limited ranges beyond the training set and using different…

Computation and Language · Computer Science 2023-08-28 Nur Lan , Emmanuel Chemla , Roni Katzir

Machine Learning Interatomic Potentials play a fundamental role in computational chemistry and materials science, enabling applications from molecular dynamics simulations to drug design and materials discovery. While recent approaches can…

Machine Learning · Computer Science 2026-05-12 Amir Masoud Nourollah , Irtaza Khalid , Stefano Leoni , Steven Schockaert

This study examines the generalization ability of algorithm performance prediction models across various benchmark suites. Comparing the statistical similarity between the problem collections with the accuracy of performance prediction…

Machine Learning · Computer Science 2024-05-22 Ana Nikolikj , Ana Kostovska , Gjorgjina Cenikj , Carola Doerr , Tome Eftimov

Recent advances in unsupervised learning have shown that unsupervised pre-training, followed by fine-tuning, can improve model generalization. However, a rigorous understanding of how the representation function learned on an unlabeled…

Machine Learning · Computer Science 2024-03-12 Yuyang Deng , Junyuan Hong , Jiayu Zhou , Mehrdad Mahdavi

Generalization beyond training data remains a central challenge in machine learning for biology. A common way to enhance generalization is self-supervised pre-training on large datasets. However, aiming to perform well on all possible…

Modern machine learning tasks often require considering not just one but multiple objectives. For example, besides the prediction quality, this could be the efficiency, robustness or fairness of the learned models, or any of their…

Machine Learning · Computer Science 2022-08-30 Peter Súkeník , Christoph H. Lampert

Algorithms for learning programmatic representations for sequential decision-making problems are often evaluated on out-of-distribution (OOD) problems, with the common conclusion that programmatic policies generalize better than neural…

Machine Learning · Computer Science 2025-06-18 Amirhossein Rajabpour , Kiarash Aghakasiri , Sandra Zilles , Levi H. S. Lelis

Score matching is a recently developed parameter learning method that is particularly effective to complicated high dimensional density models with intractable partition functions. In this paper, we study two issues that have not been…

Machine Learning · Computer Science 2012-05-14 Siwei Lyu

Semantic segmentation in a supervised learning manner has achieved significant progress in recent years. However, its performance usually drops dramatically due to the data-distribution discrepancy between seen and unseen domains when we…

Computer Vision and Pattern Recognition · Computer Science 2021-09-01 Jian Zhang , Lei Qi , Yinghuan Shi , Yang Gao

Imitation learning benchmarks often lack sufficient variation between training and evaluation, limiting meaningful generalisation assessment. We introduce Labyrinth, a benchmarking environment designed to test generalisation with precise…

Machine Learning · Computer Science 2025-09-30 Nathan Gavenski , Odinaldo Rodrigues

One of the primary challenges faced by deep learning is the degree to which current methods exploit superficial statistics and dataset bias, rather than learning to generalise over the specific representations they have experienced. This is…

Computer Vision and Pattern Recognition · Computer Science 2019-07-30 Damien Teney , Peng Wang , Jiewei Cao , Lingqiao Liu , Chunhua Shen , Anton van den Hengel

Domain generalization aims to build generalized models that perform well on unseen domains when only source domains are available for model optimization. Recent studies have shown that large-scale pre-trained models can enhance domain…

Machine Learning · Computer Science 2023-09-12 Byounggyu Lew , Donghyun Son , Buru Chang

Neural network models have been very successful in natural language inference, with the best models reaching 90% accuracy in some benchmarks. However, the success of these models turns out to be largely benchmark specific. We show that…

Computation and Language · Computer Science 2019-06-04 Aarne Talman , Stergios Chatzikyriakidis

In recent years, there has been remarkable progress in machine learning for protein-protein interactions. However, prior work has predominantly focused on improving learning algorithms, with less attention paid to evaluation strategies and…

Machine Learning · Computer Science 2024-04-17 Anton Bushuiev , Roman Bushuiev , Jiri Sedlar , Tomas Pluskal , Jiri Damborsky , Stanislav Mazurenko , Josef Sivic

Distributed learning provides an attractive framework for scaling the learning task by sharing the computational load over multiple nodes in a network. Here, we investigate the performance of distributed learning for large-scale linear…

Machine Learning · Statistics 2021-11-03 Martin Hellkvist , Ayça Özçelikkale , Anders Ahlén

A key component of automated algorithm selection and configuration, which in most cases are performed using supervised machine learning (ML) methods is a good-performing predictive model. The predictive model uses the feature representation…

Large language models (LLMs) regularly demonstrate new and impressive performance on a wide range of language, knowledge, and reasoning benchmarks. Such rapid progress has led many commentators to argue that LLM general cognitive…

Computation and Language · Computer Science 2025-02-21 James Fodor
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