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Complexity in the temporal organization of neural systems may be a reflection of the diversity of its neural constituents. These constituents, excitatory and inhibitory neurons, comprise an invariant ratio in vivo and form the substrate for…

Neurons and Cognition · Quantitative Biology 2015-05-18 Xin Chen , Rhonda Dzakpasu

Networks of excitatory and inhibitory (EI) neurons form a canonical circuit in the brain. Seminal theoretical results on dynamics of such networks are based on the assumption that synaptic strengths depend on the type of neurons they…

Neurons and Cognition · Quantitative Biology 2025-03-18 Yuxiu Shao , David Dahmen , Stefano Recanatesi , Eric Shea-Brown , Srdjan Ostojic

The neocortex has a remarkably uniform neuronal organization, suggesting that common principles of processing are employed throughout its extent. In particular, the patterns of connectivity observed in the superficial layers of the visual…

Neurons and Cognition · Quantitative Biology 2011-05-17 Ueli Rutishauser , Rodney J. Douglas , Jean-Jacques Slotine

The spatiotemporal patterns of neural dynamics are jointly shaped by directed structural interactions and heterogeneous intrinsic features of the neural components. Despite well-developed methods for estimating directionality in network…

Neurons and Cognition · Quantitative Biology 2025-10-07 Jiawen Chang , Zhuda Yang , Changsong Zhou

A critical mystery in neuroscience lies in determining how anatomical structure impacts the complex functional dynamics of human thought. How does large-scale brain circuitry constrain states of neuronal activity and transitions between…

Neurons and Cognition · Quantitative Biology 2016-07-08 Shi Gu , Matthew Cieslak , Benjamin Baird , Sarah F. Muldoon , Scott T. Grafton , Fabio Pasqualetti , Danielle S. Bassett

Understanding how the dynamics of neural networks is shaped by the computations they perform is a fundamental question in neuroscience. Recently, the framework of efficient coding proposed a theory of how spiking neural networks can compute…

Neurons and Cognition · Quantitative Biology 2022-10-25 Veronika Koren , Stefano Panzeri

Dynamical balance of excitation and inhibition is usually invoked to explain the irregular low firing activity observed in the cortex. We propose a robust nonlinear balancing mechanism for a random network of spiking neurons, which works…

Disordered Systems and Neural Networks · Physics 2025-05-29 Antonio Politi , Alessandro Torcini

It is widely appreciated that well-balanced excitation and inhibition are necessary for proper function in neural networks. However, in principle, such balance could be achieved by many possible configurations of excitatory and inhibitory…

Neurons and Cognition · Quantitative Biology 2018-11-14 Vidit Agrawal , Andrew B. Cowley , Qusay Alfaori , Juan G. Restrepo , Daniel B. Larremore , Woodrow L. Shew

A companion paper introduces a nonlinear network with Hebbian excitatory (E) neurons that are reciprocally coupled with anti-Hebbian inhibitory (I) neurons and also receive Hebbian feedforward excitation from sensory (S) afferents. The…

Neurons and Cognition · Quantitative Biology 2019-01-01 H. Sebastian Seung

This paper investigates stability conditions of continuous-time Hopfield and firing-rate neural networks by leveraging contraction theory. First, we present a number of useful general algebraic results on matrix polytopes and products of…

Optimization and Control · Mathematics 2023-05-16 Veronica Centorrino , Anand Gokhale , Alexander Davydov , Giovanni Russo , Francesco Bullo

Excitatory and inhibitory nonlinear noisy leaky integrate and fire models are often used to describe neural networks. Recently, new mathematical results have provided a better understanding of them. It has been proved that a fully…

Analysis of PDEs · Mathematics 2016-09-07 María J. Cáceres , Ricarda Schneider

Understanding how the complex connectivity structure of the brain shapes its information-processing capabilities is a long-standing question. By focusing on a paradigmatic architecture, we study how the neural activity of excitatory and…

Statistical Mechanics · Physics 2024-10-18 Giacomo Barzon , Daniel Maria Busiello , Giorgio Nicoletti

Balanced neural networks -- in which excitatory and inhibitory inputs compensate each other on average -- give rise to a dynamical phase dominated by fluctuations called asynchronous state, crucial for brain functioning. However, structural…

Statistical Mechanics · Physics 2024-03-05 Jorge Pretel , Victor Buendía , Joaquín J. Torres , Miguel A. Muñoz

Computational neuroscience models have been used for understanding neural dynamics in the brain and how they may be altered when physiological or other conditions change. We review and develop a data-driven approach to neuroimaging data…

Neurons and Cognition · Quantitative Biology 2017-05-26 Takahiro Ezaki , Takamitsu Watanabe , Masayuki Ohzeki , Naoki Masuda

Local patterns of excitation and inhibition that can generate neural waves are studied as a computational mechanism underlying the organization of neuronal tunings. Sparse coding algorithms based on networks of excitatory and inhibitory…

Neurons and Cognition · Quantitative Biology 2022-05-30 Leon Lufkin , Ashish Puri , Ganlin Song , Xinyi Zhong , John Lafferty

We propose a dynamical neural network model with a hierarchical and modular structure. The network architecture can be derived by minimizing an energy function that is originally designed based on two kinds of neurons with quite different…

Neurons and Cognition · Quantitative Biology 2026-04-14 Kazuyoshi Tsutsumi , Ernst Niebur

We investigate the collective dynamics of excitatory-inhibitory excitable networks in response to external stimuli. How to enhance dynamic range, which represents the ability of networks to encode external stimuli, is crucial to many…

Neurons and Cognition · Quantitative Biology 2013-12-24 Sen Pei , Shaoting Tang , Shu Yan , Shijin Jiang , Xiao Zhang , Zhiming Zheng

We study the stability of the dynamics of a network of n neurons intercting linearly through a random gaussian matrix of excitatory and inhibitory type. Using the aproach developed in a previous paper we show some interesting properties of…

Mathematical Physics · Physics 2011-11-10 J. F. Feng , M. Shcherbina , B. Tirozzi

In view of ever-changing conditions both in the external world and in intrinsic brain states, maintaining the robustness of computations poses a challenge, adequate solutions to which we are only beginning to understand. At the level of…

Neurons and Cognition · Quantitative Biology 2022-03-29 Nelson Niemeyer , Jan-Hendrik Schleimer , Susanne Schreiber

We initiate a line of investigation into biological neural networks from an algorithmic perspective. We develop a simplified but biologically plausible model for distributed computation in stochastic spiking neural networks and study…

Neural and Evolutionary Computing · Computer Science 2016-10-10 Nancy Lynch , Cameron Musco , Merav Parter