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Foundation models for structured electronic health records (EHRs) are pretrained on longitudinal sequences of timestamped clinical events to learn adaptable patient representations. Tokenization -- how these timelines are converted into…

Tokenization and transfer learning are two critical components in building state of the art time series foundation models for forecasting. In this work, we systematically study the effect of tokenizer design, specifically scaling and…

Machine Learning · Computer Science 2025-11-18 Alexis Roger , Gwen Legate , Kashif Rasul , Yuriy Nevmyvaka , Irina Rish

Clinical case reports encode temporal patient trajectories that are often underexploited by traditional machine learning methods relying on structured data. In this work, we introduce the forecasting problem from textual time series, where…

Computation and Language · Computer Science 2025-12-30 Shahriar Noroozizadeh , Sayantan Kumar , Jeremy C. Weiss

Every prediction from a generative medical event model is bounded by how clinical events are tokenized, yet input representation is rarely isolated from other system and architectural choices. We evaluate how representation decisions affect…

Machine Learning · Computer Science 2026-04-21 Inhyeok Lee , Luke Solo , Michael C. Burkhart , Bashar Ramadan , William F. Parker , Brett K. Beaulieu-Jones

This study introduces a novel knowledge enhanced tokenisation mechanism, K-Tokeniser, for clinical text processing. Technically, at initialisation stage, K-Tokeniser populates global representations of tokens based on semantic types of…

Computation and Language · Computer Science 2024-06-21 Abul Hasan , Jinge Wu , Quang Ngoc Nguyen , Salomé Andres , Imane Guellil , Huayu Zhang , Arlene Casey , Beatrice Alex , Bruce Guthrie , Honghan Wu

Existing time series tokenization methods predominantly encode a constant number of samples into individual tokens. This inflexible approach can generate excessive tokens for even simple patterns like extended constant values, resulting in…

Machine Learning · Computer Science 2026-01-29 Leon Götz , Marcel Kollovieh , Stephan Günnemann , Leo Schwinn

Medical coding is the task of assigning medical codes to clinical free-text documentation. Healthcare professionals manually assign such codes to track patient diagnoses and treatments. Automated medical coding can considerably alleviate…

Machine Learning · Computer Science 2023-04-24 Joakim Edin , Alexander Junge , Jakob D. Havtorn , Lasse Borgholt , Maria Maistro , Tuukka Ruotsalo , Lars Maaløe

Transformers have become the predominant architecture in foundation models due to their excellent performance across various domains. However, the substantial cost of scaling these models remains a significant concern. This problem arises…

Recent advancements in transformer-based models have greatly improved time series analysis, providing robust solutions for tasks such as forecasting, anomaly detection, and classification. A crucial element of these models is positional…

Machine Learning · Computer Science 2026-05-07 Habib Irani , Vangelis Metsis

Representing continuous time is a critical and under-explored challenge in modeling temporal event sequences with large language models (LLMs). Various strategies like byte-level representations or calendar tokens have been proposed.…

Computation and Language · Computer Science 2026-05-12 Zefang Liu , Nam H. Nguyen , Yinzhu Quan , Shi-Xiong Zhang

This study investigates the impact of masking strategies on time series imputation models in healthcare settings. While current approaches predominantly rely on random masking for model evaluation, this practice fails to capture the…

Machine Learning · Computer Science 2025-02-05 Linglong Qian , Yiyuan Yang , Wenjie Du , Jun Wang , Richard Dobsoni , Zina Ibrahim

Recent advances in deep learning architectures for sequence modeling have not fully transferred to tasks handling time-series from electronic health records. In particular, in problems related to the Intensive Care Unit (ICU), the…

Machine Learning · Computer Science 2024-02-07 Rita Kuznetsova , Alizée Pace , Manuel Burger , Hugo Yèche , Gunnar Rätsch

In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one…

Machine Learning · Computer Science 2018-12-03 Eli Sherman , Hitinder Gurm , Ulysses Balis , Scott Owens , Jenna Wiens

Accurate clinical coding is essential for healthcare documentation, billing, and decision-making. While prior work shows that off-the-shelf LLMs struggle with this task, evaluations based on exact match metrics often overlook errors where…

Computation and Language · Computer Science 2025-10-10 Zhangdie Yuan , Han-Chin Shing , Mitch Strong , Chaitanya Shivade

Normalization and scaling are fundamental preprocessing steps in time series modeling, yet their role in Transformer-based models remains underexplored from a theoretical perspective. In this work, we present the first formal analysis of…

Machine Learning · Computer Science 2026-02-20 Sofiane Ennadir , Tianze Wang , Oleg Smirnov , Sahar Asadi , Lele Cao

Transformer-based language models often achieve strong results on mathematical reasoning benchmarks while remaining fragile on basic numerical understanding and arithmetic operations. A central limitation is that numbers are processed as…

Computation and Language · Computer Science 2026-01-15 Andreea Dutulescu , Stefan Ruseti , Mihai Dascalu

Notable progress has been made in generalist medical large language models across various healthcare areas. However, large-scale modeling of in-hospital time series data - such as vital signs, lab results, and treatments in critical care -…

Tokenization is a fundamental component of large language models (LLMs), yet its influence on model scaling and performance is not fully explored. In this paper, we introduce Over-Tokenized Transformers, a novel framework that decouples…

Computation and Language · Computer Science 2025-05-26 Hongzhi Huang , Defa Zhu , Banggu Wu , Yutao Zeng , Ya Wang , Qiyang Min , Xun Zhou

International Classification of Disease (ICD) coding procedure which refers to tagging medical notes with diagnosis codes has been shown to be effective and crucial to the billing system in medical sector. Currently, ICD codes are assigned…

Computation and Language · Computer Science 2021-04-22 Biplob Biswas , Thai-Hoang Pham , Ping Zhang

Recent advances in visual generation have made significant strides in producing content of exceptional quality. However, most methods suffer from a fundamental problem - a bottleneck of inference computational efficiency. Most of these…

Computer Vision and Pattern Recognition · Computer Science 2025-02-04 Sahil Goyal , Debapriya Tula , Gagan Jain , Pradeep Shenoy , Prateek Jain , Sujoy Paul
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