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Genome-wide association studies (GWAS) have successfully identified a large number of genetic variants associated with traits and diseases. However, it still remains challenging to fully understand functional mechanisms underlying many…

Genomics · Quantitative Biology 2022-04-15 Qiaolan Deng , Jin Hyun Nam , Ayse Selen Yilmaz , Won Chang , Maciej Pietrzak , Lang Li , Hang J. Kim , Dongjun Chung

Differential Privacy (DP) provides strong guarantees on the risk of compromising a user's data in statistical learning applications, though these strong protections make learning challenging and may be too stringent for some use cases. To…

Machine Learning · Computer Science 2019-12-10 Hilal Asi , John Duchi , Omid Javidbakht

The paper redefines econometric identification under formal privacy constraints, particularly differential privacy (DP). Traditionally, econometrics focuses on point or partial identification, aiming to recover parameters precisely or…

Econometrics · Economics 2025-11-06 Tatiana Komarova , Denis Nekipelov

Networks are crucial components of many sectors, including telecommunications, healthcare, finance, energy, and transportation.The information carried in such networks often contains sensitive user data, like location data for commuters and…

Cryptography and Security · Computer Science 2024-08-13 Ferdinando Fioretto , Diptangshu Sen , Juba Ziani

In this paper, association results from genome-wide association studies (GWAS) are combined with a deep learning framework to test the predictive capacity of statistically significant single nucleotide polymorphism (SNPs) associated with…

Computers and Society · Computer Science 2018-08-27 Casimiro Adays Curbelo Montañez , Paul Fergus , Almudena Curbelo Montañez , Carl Chalmers

Publishing open graph data while preserving individual privacy remains challenging when data publishers and data users are distinct entities. Although differential privacy (DP) provides rigorous guarantees, most existing approaches enforce…

Machine Learning · Computer Science 2026-03-25 Muhao Guo , Jiaqi Wu , Yizheng Liao , Wenke Lee , Shengzhe Chen , Yang Weng

Motivation: In spite of great success of genome-wide association studies (GWAS), multiple challenges still remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), each with small or moderate…

Spontaneous reporting systems (SRS) have been developed to collect adverse event records that contain personal demographics and sensitive information like drug indications and adverse reactions. The release of SRS data may disclose the…

Cryptography and Security · Computer Science 2022-11-22 Yi-Yuang Wu , Zhi-Xun Shen , Wen-Yang Lin

Differential Privacy (DP) is a probabilistic framework that protects privacy while preserving data utility. To protect the privacy of the individuals in the dataset, DP requires adding a precise amount of noise to a statistic of interest;…

Computation · Statistics 2025-05-05 Yu-Wei Chen , Pranav Sanghi , Jordan Awan

Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss…

Methodology · Statistics 2010-10-26 Peter Kraft , Eleftheria Zeggini , John P. A. Ioannidis

The increased use of differential privacy (DP) has allowed the sharing of large amounts of data while reducing the risk of disclosure of sensitive information at the individual level. However, the noise introduced by DP methods makes…

Methodology · Statistics 2026-04-29 Jordan Awan , Xi Chen , Roberto Molinari

While pursuing better utility by discovering knowledge from the data, individual's privacy may be compromised during an analysis. To that end, differential privacy has been widely recognized as the state-of-the-art privacy notion. By…

Cryptography and Security · Computer Science 2022-09-07 Meisam Mohammady

Personalized privacy becomes critical in deep learning for Trustworthy AI. While Differentially Private Stochastic Gradient Descent (DP-SGD) is widely used in deep learning methods supporting privacy, it provides the same level of privacy…

Machine Learning · Computer Science 2023-05-25 Geon Heo , Junseok Seo , Steven Euijong Whang

Motivated by understanding the dynamics of sensitive social networks over time, we consider the problem of continual release of statistics in a network that arrives online, while preserving privacy of its participants. For our privacy…

Cryptography and Security · Computer Science 2018-09-20 Shuang Song , Susan Little , Sanjay Mehta , Staal Vinterbo , Kamalika Chaudhuri

Differential privacy (DP) quantifies privacy loss by analyzing noise injected into output statistics. For non-trivial statistics, this noise is necessary to ensure finite privacy loss. However, data curators frequently release collections…

Cryptography and Security · Computer Science 2022-12-15 Jeremy Seeman , Matthew Reimherr , Aleksandra Slavkovic

Differential privacy (DP) is a mathematical privacy notion increasingly deployed across government and industry. With DP, privacy protections are probabilistic: they are bounded by the privacy budget parameter, $\epsilon$. Prior work in…

Cryptography and Security · Computer Science 2023-03-02 Priyanka Nanayakkara , Mary Anne Smart , Rachel Cummings , Gabriel Kaptchuk , Elissa Redmiles

Differentially private (DP) mechanisms face the challenge of providing accurate results while protecting their inputs: the privacy-utility trade-off. A simple but powerful technique for DP adds noise to sensitivity-bounded query outputs to…

Cryptography and Security · Computer Science 2021-07-28 David M. Sommer , Lukas Abfalterer , Sheila Zingg , Esfandiar Mohammadi

We introduce the novel problem of benchmarking fraud detectors on private graph-structured data. Currently, many types of fraud are managed in part by automated detection algorithms that operate over graphs. We consider the scenario where a…

Cryptography and Security · Computer Science 2025-07-31 Alexander Goldberg , Giulia Fanti , Nihar Shah , Zhiwei Steven Wu

In this work, we study the applications of differential privacy (DP) in the context of graph-structured data. We discuss the formulations of DP applicable to the publication of graphs and their associated statistics as well as machine…

Cryptography and Security · Computer Science 2022-03-18 Tamara T. Mueller , Dmitrii Usynin , Johannes C. Paetzold , Daniel Rueckert , Georgios Kaissis

In this paper, we design Top-DP, a novel solution to optimize the differential privacy protection of decentralized image classification systems. The key insight of our solution is to leverage the unique features of decentralized…

Cryptography and Security · Computer Science 2021-09-03 Shangwei Guo , Tianwei Zhang , Guowen Xu , Han Yu , Tao Xiang , Yang Liu