English
Related papers

Related papers: GOPHER: Optimization-based Phenotype Randomization…

200 papers

Graph data is increasingly prevalent across domains, offering analytical value but raising significant privacy concerns. Edges may encode sensitive relationships, while node attributes may contain sensitive entity or personal data.…

Cryptography and Security · Computer Science 2026-04-07 Nicholas D'Silva , Surya Nepal , Salil S. Kanhere

Data engineering often requires accuracy (utility) constraints on results, posing significant challenges in designing differentially private (DP) mechanisms, particularly under stringent privacy parameter $\epsilon$. In this paper, we…

Cryptography and Security · Computer Science 2024-12-17 Bo Jiang , Wanrong Zhang , Donghang Lu , Jian Du , Sagar Sharma , Qiang Yan

Genome Wide Association Studies (GWAS) are used to identify statistically significant genetic variants in case-control studies. GWAS typically use a p-value threshold of 5 x 10-8 to identify highly ranked single nucleotide polymorphisms…

Computational Engineering, Finance, and Science · Computer Science 2018-01-10 Paul Fergus , Casimiro Curbelo Montanez , Basma Abdulaimma , Paulo Lisboa , Carl Chalmers

Genome-wide association studies (GWAS) have successfully identified over two hundred thousand genotype-trait associations. Yet some challenges remain. First, complex traits are often associated with many single nucleotide polymorphisms…

Methodology · Statistics 2023-02-07 Aastha Khatiwada , Ayse Selen Yilmaz , Bethany J. Wolf , Maciej Pietrzak , Dongjun Chung

The availability of rich and vast data sources has greatly advanced machine learning applications in various domains. However, data with privacy concerns comes with stringent regulations that frequently prohibited data access and data…

Machine Learning · Computer Science 2023-09-28 Dingfan Chen , Raouf Kerkouche , Mario Fritz

We propose a method for the release of differentially private synthetic datasets. In many contexts, data contain sensitive values which cannot be released in their original form in order to protect individuals' privacy. Synthetic data is a…

Methodology · Statistics 2018-05-25 Joshua Snoke , Aleksandra Slavković

Differential privacy (DP) is a widely used notion for reasoning about privacy when publishing aggregate data. In this paper, we observe that certain DP mechanisms are amenable to a posteriori privacy analysis that exploits the fact that…

Cryptography and Security · Computer Science 2023-06-21 Valentin Hartmann , Vincent Bindschaedler , Alexander Bentkamp , Robert West

Achieving differential privacy (DP) guarantees in fully decentralized machine learning is challenging due to the absence of a central aggregator and varying trust assumptions among nodes. We present a framework for DP analysis of…

Machine Learning · Computer Science 2026-02-06 Antti Koskela , Tejas Kulkarni

For the vast majority of genome wide association studies (GWAS) published so far, statistical analysis was performed by testing markers individually. In this article we present some elementary statistical considerations which clearly show…

Applications · Statistics 2010-10-04 Florian Frommlet , Felix Ruhaltinger , Piotr Twarog , Malgorzata Bogdan

Large case/control Genome-Wide Association Studies (GWAS) often include groups of related individuals with known relationships. When testing for associations at a given locus, current methods incorporate only the familial relationships…

Applications · Statistics 2014-08-01 Joshua N. Sampson , Bill Wheeler , Peng Li , Jianxin Shi

In recent years, the growth of data across various sectors, including healthcare, security, finance, and education, has created significant opportunities for analysis and informed decision-making. However, these datasets often contain…

Machine Learning · Statistics 2026-04-30 Utsab Saha , Tanvir Muntakim Tonoy , Hafiz Imtiaz

Graph Neural Networks (GNNs) have achieved great success in learning with graph-structured data. Privacy concerns have also been raised for the trained models which could expose the sensitive information of graphs including both node…

Machine Learning · Computer Science 2024-03-18 Qiuchen Zhang , Hong kyu Lee , Jing Ma , Jian Lou , Carl Yang , Li Xiong

Differential privacy (DP) provides robust privacy guarantees for statistical inference, but this can lead to unreliable results and biases in downstream applications. While several noise-aware approaches have been proposed which integrate…

Machine Learning · Statistics 2026-05-29 Talal Alrawajfeh , Joonas Jälkö , Antti Honkela

Genome-wide association studies (GWAS) are used to identify relationships between genetic variations and specific traits. When applied to high-dimensional medical imaging data, a key step is to extract lower-dimensional, yet informative…

Quantitative Methods · Quantitative Biology 2023-09-28 Yaochen Xie , Ziqian Xie , Sheikh Muhammad Saiful Islam , Degui Zhi , Shuiwang Ji

It is common practice to use data containing personal information to build predictive models in the framework of empirical risk minimization (ERM). While these models can be highly accurate in prediction, sharing the results from these…

Machine Learning · Statistics 2024-09-30 Spencer Giddens , Yiwang Zhou , Kevin R. Krull , Tara M. Brinkman , Peter X. K. Song , Fang Liu

Differentially private (DP) mechanisms protect individual-level information by introducing randomness into the statistical analysis procedure. Despite the availability of numerous DP tools, there remains a lack of general techniques for…

Machine Learning · Statistics 2025-09-25 Zhanyu Wang , Guang Cheng , Jordan Awan

The Gaussian mechanism is an essential building block used in multitude of differentially private data analysis algorithms. In this paper we revisit the Gaussian mechanism and show that the original analysis has several important…

Machine Learning · Computer Science 2018-06-08 Borja Balle , Yu-Xiang Wang

GNNs can inadvertently expose sensitive user information and interactions through their model predictions. To address these privacy concerns, Differential Privacy (DP) protocols are employed to control the trade-off between provable privacy…

Machine Learning · Computer Science 2023-10-17 Eli Chien , Wei-Ning Chen , Chao Pan , Pan Li , Ayfer Özgür , Olgica Milenkovic

Differential privacy is known to protect against threats to validity incurred due to adaptive, or exploratory, data analysis -- even when the analyst adversarially searches for a statistical estimate that diverges from the true value of the…

Cryptography and Security · Computer Science 2022-07-25 Elbert Du , Cynthia Dwork

Training generative models with differential privacy (DP) typically involves injecting noise into gradient updates or adapting the discriminator's training procedure. As a result, such approaches often struggle with hyper-parameter tuning…

Machine Learning · Computer Science 2024-10-29 Kristjan Greenewald , Yuancheng Yu , Hao Wang , Kai Xu