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Digital pathology offers a groundbreaking opportunity to transform clinical practice in histopathological image analysis, yet faces a significant hurdle: the substantial file sizes of pathological Whole Slide Images (WSI). While current…

Digital pathology enables automatic analysis of histopathological sections using artificial intelligence (AI). Automatic evaluation could improve diagnostic efficiency and help find associations between morphological features and clinical…

The rising prevalence of chronic wounds, especially in aging populations, presents a significant healthcare challenge due to prolonged hospitalizations, elevated costs, and reduced patient quality of life. Traditional wound care is…

Human-Computer Interaction · Computer Science 2025-06-09 Vanessa Borst , Anna Riedmann , Tassilo Dege , Konstantin Müller , Astrid Schmieder , Birgit Lugrin , Samuel Kounev

We introduce AI on the Pulse, a real-world-ready anomaly detection system that continuously monitors patients using a fusion of wearable sensors, ambient intelligence, and advanced AI models. Powered by UniTS, a state-of-the-art (SoTA)…

Machine Learning · Computer Science 2025-08-06 Davide Gabrielli , Bardh Prenkaj , Paola Velardi , Stefano Faralli

[Purpose] The pathology is decisive for disease diagnosis, but relies heavily on the experienced pathologists. Recently, pathological artificial intelligence (PAI) is thought to improve diagnostic accuracy and efficiency. However, the high…

Image and Video Processing · Electrical Eng. & Systems 2022-05-25 Yuanqing Yang , Kai Sun , Yanhua Gao , Kuangsong Wang , Gang Yu

Goal: Squamous cell carcinoma of cervix is one of the most prevalent cancer worldwide in females. Traditionally, the most indispensable diagnosis of cervix squamous carcinoma is histopathological assessment which is achieved under…

Computer Vision and Pattern Recognition · Computer Science 2019-05-28 Ye Tian , Li Yang , Wei Wang , Jing Zhang , Qing Tang , Mili Ji , Yang Yu , Yu Li , Hong Yang , Airong Qian

Analyzing whole-slide images (WSIs) requires an iterative, evidence-driven reasoning process that parallels how pathologists dynamically zoom, refocus, and self-correct while collecting the evidence. However, existing computational…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Jingyun Chen , Linghan Cai , Zhikang Wang , Yi Huang , Songhan Jiang , Shenjin Huang , Hongpeng Wang , Yongbing Zhang

Artificial Intelligence (AI)-powered pathology is a revolutionary step in the world of digital pathology and shows great promise to increase both diagnosis accuracy and efficiency. However, defocus and motion blur can obscure tissue or cell…

Image and Video Processing · Electrical Eng. & Systems 2020-11-25 Cheng Jiang , Jun Liao , Pei Dong , Zhaoxuan Ma , De Cai , Guoan Zheng , Yueping Liu , Hong Bu , Jianhua Yao

Current approaches for classification of whole slide images (WSI) in digital pathology predominantly utilize a two-stage learning pipeline. The first stage identifies areas of interest (e.g. tumor tissue), while the second stage processes…

Computer Vision and Pattern Recognition · Computer Science 2022-07-20 Marvin Teichmann , Andre Aichert , Hanibal Bohnenberger , Philipp Ströbel , Tobias Heimann

Widespread clinical deployment of computer-aided diagnosis (CAD) systems is hindered by the challenge of integrating with existing hospital IT infrastructure. Here, we introduce VisionCAD, a vision-based radiological assistance framework…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Jiaming Li , Junlei Wu , Sheng Wang , Honglin Xiong , Jiangdong Cai , Zihao Zhao , Yitao Zhu , Yuan Yin , Dinggang Shen , Qian Wang

Traditional whole slide image (WSI) analysis methods typically rely on the multiple instance learning (MIL) paradigm, which extracts patch-level features at high magnification and aggregates them for slide-level prediction. However, such…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Jiusong Ge , Yingkang Zhan , Wenjie Zhao , Di Zhang , Ke Wang , Jiashuai Liu , Chunze Yang , Chengzu Li , Jian Zhang , Yuxin Dong , Ni Zhang , Qidong Liu , Mireia Crispin-Ortuzar , Huazhu Fu , Chen Li , Zeyu Gao

Histopathological image analysis is crucial for accurate cancer diagnosis and treatment planning. While deep learning models, especially convolutional neural networks, have advanced this field, their "black-box" nature raises concerns about…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Pardis Afshar , Sajjad Hashembeiki , Pouya Khani , Emad Fatemizadeh , Mohammad Hossein Rohban

As advances in large language models (LLMs) and multimodal techniques continue to mature, the development of general-purpose multimodal large language models (MLLMs) has surged, offering significant applications in interpreting natural…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 Yuxuan Sun , Chenglu Zhu , Sunyi Zheng , Kai Zhang , Lin Sun , Zhongyi Shui , Yunlong Zhang , Honglin Li , Lin Yang

Histology slide digitization is becoming essential for telepathology (remote consultation), knowledge sharing (education), and using the state-of-the-art artificial intelligence algorithms (augmented/automated end-to-end clinical…

Image and Video Processing · Electrical Eng. & Systems 2024-05-15 Talat Zehra , Joseph Marino , Wendy Wang , Grigoriy Frantsuzov , Saad Nadeem

Drug-induced toxicity remains a leading cause of failure in preclinical development and early clinical trials. Detecting adverse effects at an early stage is critical to reduce attrition and accelerate the development of safe medicines.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Olga Graf , Dhrupal Patel , Peter Groß , Charlotte Lempp , Matthias Hein , Fabian Heinemann

While previous studies have demonstrated the potential of AI to diagnose diseases in imaging data, clinical implementation is still lagging behind. This is partly because AI models require training with large numbers of examples only…

Artificial intelligence (AI) has shown great promise for diagnostic imaging assessments. However, the application of AI to support medical diagnostics in clinical routine comes with many challenges. The algorithms should have high…

Computer Vision and Pattern Recognition · Computer Science 2020-08-17 Milda Pocevičiūtė , Gabriel Eilertsen , Claes Lundström

Whole Slide Images (WSIs) in digital pathology are used to diagnose cancer subtypes. The difference in procedures to acquire WSIs at various trial sites gives rise to variability in the histopathology images, thus making consistent…

Image and Video Processing · Electrical Eng. & Systems 2022-04-07 Milad Sikaroudi , Shahryar Rahnamayan , H. R. Tizhoosh

Histopathological analysis is the present gold standard for precancerous lesion diagnosis. The goal of automated histopathological classification from digital images requires supervised training, which requires a large number of expert…

Image and Video Processing · Electrical Eng. & Systems 2021-11-15 Yuan Xue , Jiarong Ye , Qianying Zhou , Rodney Long , Sameer Antani , Zhiyun Xue , Carl Cornwell , Richard Zaino , Keith Cheng , Xiaolei Huang

Histopathology remains the gold standard for diagnosis of various cancers. Recent advances in computer vision, specifically deep learning, have facilitated the analysis of histopathology images for various tasks, including immune cell…

Quantitative Methods · Quantitative Biology 2023-11-02 Jakub R. Kaczmarzyk , Tahsin M. Kurc , Shahira Abousamra , Rajarsi Gupta , Joel H. Saltz , Peter K. Koo