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Gene finding is the task of identifying the locations of coding sequences within the vast amount of genetic code contained in the genome. With an ever increasing quantity of raw genome sequences, gene finding is an important avenue towards…

Genomics · Quantitative Biology 2025-05-07 Frederikke I. Marin , Dennis Pultz , Wouter Boomsma

Deep neural network learning can be formulated as a non-convex optimization problem. Existing optimization algorithms, e.g., Adam, can learn the models fast, but may get stuck in local optima easily. In this paper, we introduce a novel…

Machine Learning · Computer Science 2019-03-12 Jiawei Zhang , Fisher B. Gouza

Bayesian Optimization (BO) has shown significant success in tackling expensive low-dimensional black-box optimization problems. Many optimization problems of interest are high-dimensional, and scaling BO to such settings remains an…

Machine Learning · Statistics 2022-06-02 Eric Han , Ishank Arora , Jonathan Scarlett

Learning systems deployed in nonstationary and safety-critical environments often suffer from instability, slow convergence, or brittle adaptation when learning dynamics evolve over time. While modern optimization, reinforcement learning,…

Machine Learning · Computer Science 2026-01-05 Akash Samanta , Sheldon Williamson

Coarse-grained (CG) molecular dynamics enables simulations of atomic systems such as biomolecules at timescales inaccessible to all-atom (AA) methods, but existing CG neural potentials trained via force matching capture only the gradient of…

Machine Learning · Computer Science 2026-05-14 Sanya Murdeshwar , Sanjit Shashi , Kevin Bachelor , William Noid , Ashwin Lokapally , Razvan Marinescu

This paper introduces a comprehensive framework for the evaluation and validation of generative language models (GLMs), with a focus on Retrieval-Augmented Generation (RAG) systems deployed in high-stakes domains such as banking. GLM…

Computation and Language · Computer Science 2024-12-10 Agus Sudjianto , Aijun Zhang , Srinivas Neppalli , Tarun Joshi , Michal Malohlava

Continual learning (CL) is a fundamental topic in machine learning, where the goal is to train a model with continuously incoming data and tasks. Due to the memory limit, we cannot store all the historical data, and therefore confront the…

Machine Learning · Computer Science 2024-07-31 Weichen Lin , Jiaxiang Chen , Ruomin Huang , Hu Ding

Convolutional Neural Networks (CNNs) have gained a significant attraction in the recent years due to their increasing real-world applications. Their performance is highly dependent to the network structure and the selected optimization…

Neural and Evolutionary Computing · Computer Science 2019-10-01 Parsa Esfahanian , Mohammad Akhavan

HyperParameter Optimization (HPO) aims at finding the best HyperParameters (HPs) of learning models, such as neural networks, in the fastest and most efficient way possible. Most recent HPO algorithms try to optimize HPs regardless of the…

Machine Learning · Computer Science 2023-04-11 Antoine Scardigli , Paul Fournier , Matteo Vilucchio , David Naccache

We propose a genetic algorithm (GA) based method for modifying n-best lists produced by a machine translation (MT) system. Our method offers an innovative approach to improving MT quality and identifying weaknesses in evaluation metrics.…

Computation and Language · Computer Science 2023-06-01 Josef Jon , Ondřej Bojar

Inferring the most likely configuration for a subset of variables of a joint distribution given the remaining ones - which we refer to as co-generation - is an important challenge that is computationally demanding for all but the simplest…

Computer Vision and Pattern Recognition · Computer Science 2019-11-01 Tiantian Fang , Alexander G. Schwing

Machine Learning algorithms have been extensively researched throughout the last decade, leading to unprecedented advances in a broad range of applications, such as image classification and reconstruction, object recognition, and text…

Artificial Intelligence · Computer Science 2022-12-20 Gustavo H. de Rosa , Mateus Roder , João Paulo Papa , Claudio F. G. dos Santos

The high dimensional nature of genomics data complicates feature selection, in particular in low sample size studies - not uncommon in clinical prediction settings. It is widely recognized that complementary data on the features, `co-data',…

Methodology · Statistics 2024-05-09 Mark A. van de Wiel , Wessel N. van Wieringen

Various variants of the well known Covariance Matrix Adaptation Evolution Strategy (CMA-ES) have been proposed recently, which improve the empirical performance of the original algorithm by structural modifications. However, in practice it…

Neural and Evolutionary Computing · Computer Science 2018-08-20 Sander van Rijn , Hao Wang , Matthijs van Leeuwen , Thomas Bäck

Graph augmentations are essential for graph contrastive learning. Most existing works use pre-defined random augmentations, which are usually unable to adapt to different input graphs and fail to consider the impact of different nodes and…

Machine Learning · Computer Science 2023-03-28 Yifu Chen , Qianqian Ren , Liu Yong

Collecting operationally realistic data to inform machine learning models can be costly. Before collecting new data, it is helpful to understand where a model is deficient. For example, object detectors trained on images of rare objects may…

Machine Learning · Statistics 2025-12-24 Anna R. Flowers , Christopher T. Franck , Robert B. Gramacy , Justin A. Krometis

Evolutionary strategies have recently been shown to achieve competing levels of performance for complex optimization problems in reinforcement learning. In such problems, one often needs to optimize an objective function subject to a set of…

Neural and Evolutionary Computing · Computer Science 2022-02-23 Youssef Diouane , Aurelien Lucchi , Vihang Patil

Symbolic-inference methods have recently found a broad application in materials science. In particular, the Sure-Independence Screening and Sparsifying Operator (SISSO) performs symbolic regression and classification by adopting compressed…

Materials Science · Physics 2024-03-26 Aliaksei Mazheika , Sergey V. Levchenko , Luca M. Ghiringhelli

Feature selection is a combinatorial optimization problem that is NP-hard. Conventional approaches often employ heuristic or greedy strategies, which are prone to premature convergence and may fail to capture subtle yet informative…

Machine Learning · Computer Science 2025-10-22 Yusi Fan , Tian Wang , Zhiying Yan , Chang Liu , Qiong Zhou , Qi Lu , Zhehao Guo , Ziqi Deng , Wenyu Zhu , Ruochi Zhang , Fengfeng Zhou

We propose a data-driven mean-curvature solver for the level-set method. This work is the natural extension to $\mathbb{R}^3$ of our two-dimensional strategy in [DOI: 10.1007/s10915-022-01952-2][1] and the hybrid inference system of [DOI:…

Machine Learning · Computer Science 2022-12-12 Luis Ángel Larios-Cárdenas , Frédéric Gibou
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