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Process mining sheds new light on the relationship between process models and real-life processes. Process discovery can be used to learn process models from event logs. Conformance checking is concerned with quantifying the quality of a…

Artificial Intelligence · Computer Science 2019-09-06 Anja F. Syring , Niek Tax , Wil M. P. van der Aalst

Recently, medical image synthesis gains more and more popularity, along with the rapid development of generative models. Medical image synthesis aims to generate an unacquired image modality, often from other observed data modalities.…

Image and Video Processing · Electrical Eng. & Systems 2025-07-04 Zhe Xiong , Qiaoqiao Ding , Xiaoqun Zhang

Medical image analysis faces significant challenges in data sharing due to privacy regulations and complex institutional protocols. Dataset distillation offers a solution to address these challenges by synthesizing compact datasets that…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Le Dong , Jinghao Bian , Jingyang Hou , Jingliang Hu , Yilei Shi , Weisheng Dong , Xiao Xiang Zhu , Lichao Mou

Clinical pathways are disseminated as visual flowcharts where spatial topology, arrow direction, colour coding, and font weight encode critical triage logic that remains inaccessible to computational systems. We present PathWISE, a…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Sofiat Abioye , Ufaq Khan , Shazad Ashraf , Mohammed Adil Butt , Andrew D. Beggs , Adam Byfield , Anusha Jose , William Poulett , Ben Wallace , Junaid Qadir , Muhammad Bilal

Existing approaches for predictive process monitoring are sub-symbolic, meaning that they learn correlations between descriptive features and a target feature fully based on data, e.g., predicting the surgical needs of a patient based on…

Artificial Intelligence · Computer Science 2026-04-01 Fabrizio De Santis , Gyunam Park , Wil M. P. van der Aalst , Francesco Zanichelli

HealthBranches is a novel benchmark dataset for medical Question-Answering (Q&A), specifically designed to evaluate complex reasoning in Large Language Models (LLMs). This dataset is generated through a semi-automated pipeline that…

Computation and Language · Computer Science 2025-08-12 Cristian Cosentino , Annamaria Defilippo , Marco Dossena , Christopher Irwin , Sara Joubbi , Pietro Liò

Foundation models for computational pathology are expected to facilitate the development of high-performing, generalisable deep learning systems. However, in addition to biologically relevant features, current foundation models also capture…

Understanding disease progression at the molecular pathway level usually requires capturing both structural dependencies between pathways and the temporal dynamics of disease evolution. In this work, we solve the former challenge by…

Machine Learning · Computer Science 2025-02-11 Dai Shi , Kuan Yan , Lequan Lin , Yue Zeng , Ting Zhang , Dmytro Matsypura , Mark C. Gillies , Ling Zhu , Junbin Gao

In recent years, process mining emerged as a proven technology to analyze and improve operational processes. An expanding range of organizations using process mining in their daily operation brings a broader spectrum of processes to be…

Machine Learning · Computer Science 2023-11-07 Viki Peeva , Wil M. P. van der Aalst

Process mining is a relatively new subject which builds a bridge between process modelling and data mining. An exclusive choice in a process model usually splits the process into different branches. However, in some processes, it is…

Databases · Computer Science 2021-06-25 Yang Lu , Qifan Chen , Simon Poon

Clinical decision support systems are assisting physicians in providing care to patients. However, in the context of clinical pathway management such systems are rather limited as they only take the current state of the patient into account…

Computers and Society · Computer Science 2021-04-13 Hong Sun , Dörthe Arndt , Jos De Roo , Erik Mannens

Artificial intelligence may assist healthcare systems in meeting increasing demand for pathology services while maintaining diagnostic quality and reducing turnaround time and costs. We aimed to investigate the performance of an…

The management of health data, from their gathering to their analysis, arises a number of challenging issues due to their highly confidential nature. In particular, this dissertation contributes to several security and privacy challenges…

Cryptography and Security · Computer Science 2022-06-30 Edgar Batista

Clinical decision-making relies on the integration of information across various data modalities, such as clinical time-series, medical images and textual reports. Compared to other domains, real-world medical data is heterogeneous in…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Baraa Al Jorf , Farah Shamout

A key overall goal of biomolecular simulations is the characterization of "mechanism" -- the pathways through configuration space of processes such as conformational transitions and binding. Some amount of heterogeneity is intrinsic to the…

Chemical Physics · Physics 2018-10-25 Ernesto Suárez , Daniel M. Zuckerman

The research explores the utilization of a deep learning model employing an attention mechanism in medical text mining. It targets the challenge of analyzing unstructured text information within medical data. This research seeks to enhance…

Computation and Language · Computer Science 2024-06-04 Lingxi Xiao , Muqing Li , Yinqiu Feng , Meiqi Wang , Ziyi Zhu , Zexi Chen

Medical professionals, especially those in training, often depend on visual reference materials to support an accurate diagnosis and develop pattern recognition skills. However, existing resources may lack the diversity and accessibility…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Kanishk Choudhary

We performed "weighted ensemble" path-sampling simulations of adenylate kinase, using several semi-atomistic protein models. Our study investigated both the biophysics of conformational transitions as well as the possibility of increasing…

Biological Physics · Physics 2010-02-25 Divesh Bhatt , Daniel M. Zuckerman

Sampled structure sequences obtained, for instance, from real-time reactivity explorations or first-principles molecular dynamics simulations contain valuable information about chemical reactivity. Eventually, such sequences allow for the…

Chemical Physics · Physics 2018-04-25 Michael A. Heuer , Alain C. Vaucher , Moritz P. Haag , Markus Reiher

Learning causal relationships from time series data is an important but challenging problem. Existing synthetic datasets often contain hidden artifacts that can be exploited by causal discovery methods, reducing their usefulness for…

Machine Learning · Computer Science 2026-03-23 Xiaoyu He , Petr Ryšavý , Jakub Mareček