Related papers: Joint Progression Modeling (JPM): A Probabilistic …

Joint modeling has become increasingly popular for characterizing the association between one or more longitudinal biomarkers and competing risks time-to-event outcomes. However, semiparametric multivariate joint modeling for large-scale…

Machine learning models have exhibited exceptional results in various domains. The most prevalent approach for learning is the empirical risk minimizer (ERM), which adapts the model's weights to reduce the loss on a training set and…

Unlike natural images, medical images often have intrinsic characteristics that can be leveraged for neural network learning. For example, images that belong to different stages of a disease may continuously follow a certain progression…

To extend cognitive diagnostic models (CDMs) to longitudinal settings, stepwise approaches that integrate a CDM model with a latent transition model and covariates are widely used due to their flexibility. Previous research has shown that…

In industrial experiments, controlling variability is of paramount importance to ensure product quality. Classical regression models for mixture experiments are widely used in industry, however, when the assumption of constant variance is…

Atypical Parkinsonian Disorders (APD), also known as Parkinson-plus syndrome, are a group of neurodegenerative diseases that include progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). In the early stages, overlapping…

Knowing the uncertainty in a prediction is critical when making expensive investment decisions and when patient safety is paramount, but machine learning (ML) models in drug discovery typically provide only a single best estimate and ignore…

Energy-Based Models (EBMs) present a flexible and appealing way to represent uncertainty. Despite recent advances, training EBMs on high-dimensional data remains a challenging problem as the state-of-the-art approaches are costly, unstable,…

This paper investigates two prominent probabilistic neural modeling paradigms: Bayesian Neural Networks (BNNs) and Mixture Density Networks (MDNs) for uncertainty-aware nonlinear regression. While BNNs incorporate epistemic uncertainty by…

This paper studies the fundamental problem of learning multi-layer generator models. The multi-layer generator model builds multiple layers of latent variables as a prior model on top of the generator, which benefits learning complex data…

Diagnosing Alzheimer's disease (AD) involves a deliberate diagnostic process owing to its innate traits of irreversibility with subtle and gradual progression. These characteristics make AD biomarker identification from structural brain…

This study introduces an integrated framework for predictive causal inference designed to overcome limitations inherent in conventional single model approaches. Specifically, we combine a Hidden Markov Model (HMM) for spatial health state…

Literature on machine learning for multiple sclerosis has primarily focused on the use of neuroimaging data such as magnetic resonance imaging and clinical laboratory tests for disease identification. However, studies have shown that these…

In regression models, predictor variables with inherent ordering, such as tumor staging ranging and ECOG performance status, are commonly seen in medical settings. Statistically, it may be difficult to determine the functional form of an…

Motivated by recent findings that within-subject (WS) visit-to-visit variabilities of longitudinal biomarkers can be strong risk factors for health outcomes, this paper introduces and examines a new joint model of a longitudinal biomarker…

In the advent of democratized usage of large language models (LLMs), there is a growing desire to systematize LLM prompt creation and selection processes beyond iterative trial-and-error. Prior works majorly focus on searching the space of…

Mixtures of Mallows models are a popular generative model for ranking data coming from a heterogeneous population. They have a variety of applications including social choice, recommendation systems and natural language processing. Here we…

We consider the estimation of Dirichlet Process Mixture Models (DPMMs) in distributed environments, where data are distributed across multiple computing nodes. A key advantage of Bayesian nonparametric models such as DPMMs is that they…

Knowledge stored in large language models requires timely updates to reflect the dynamic nature of real-world information. To update the knowledge, most knowledge editing methods focus on the low layers, since recent probes into the…

Disease progression models are widely used to inform the diagnosis and treatment of many progressive diseases. However, a significant limitation of existing models is that they do not account for health disparities that can bias the…