English
Related papers

Related papers: Unlocking hidden biomolecular conformational lands…

200 papers

Inferring dynamical models from low-resolution temporal data continues to be a significant challenge in biophysics, especially within transcriptomics, where separating molecular programs from noise remains an important open problem. We…

Machine Learning · Computer Science 2023-10-05 Victor Chardès , Suryanarayana Maddu , Michael J. Shelley

The predominant success of diffusion models in generative modeling has spurred significant interest in understanding their theoretical foundations. In this work, we propose a feature learning framework aimed at analyzing and comparing the…

Machine Learning · Statistics 2025-03-04 Andi Han , Wei Huang , Yuan Cao , Difan Zou

This article demonstrates that flexible and statistically tractable multi-modal diffusion models can be attained by transformation of simple well-known diffusion models such as the Ornstein-Uhlenbeck model, or more generally a Pearson…

Methodology · Statistics 2013-04-04 Julie Forman , Michael Sørensen

Diffusion Models have become a cornerstone of modern generative AI for their exceptional generation quality and controllability. However, their inherent \textit{multi-step iterations} and \textit{complex backbone networks} lead to…

Understanding and predicting microstructure evolution is fundamental to materials science, as it governs the resulting properties and performance of materials. Traditional simulation methods, such as phase-field models, offer high-fidelity…

Machine Learning · Computer Science 2026-02-24 Michael Trimboli , Mohammed Alsubaie , Sirani M. Perera , Ke-Gang Wang , Xianqi Li

We present Bayesian Diffusion Models (BDM), a prediction algorithm that performs effective Bayesian inference by tightly coupling the top-down (prior) information with the bottom-up (data-driven) procedure via joint diffusion processes. We…

Computer Vision and Pattern Recognition · Computer Science 2024-04-23 Haiyang Xu , Yu Lei , Zeyuan Chen , Xiang Zhang , Yue Zhao , Yilin Wang , Zhuowen Tu

Modern deep learning methods have achieved impressive results across tasks from disease classification, estimating continuous biomarkers, to generating realistic medical images. Most of these approaches are trained to model conditional…

This paper introduces a new technique for learning probabilistic models of mass and friction distributions of unknown objects, and performing robust sliding actions by using the learned models. The proposed method is executed in two…

Robotics · Computer Science 2020-08-06 Changkyu Song , Abdeslam Boularias

A core challenge in structural biophysics is generating biomolecular conformations that are both physically plausible and consistent with experimental measurements. While sequence-to-structure diffusion models provide powerful priors,…

Machine Learning · Computer Science 2026-05-15 Minhuan Li , Jiequn Han , Pilar Cossio , Luhuan Wu

Diffusion models are emerging expressive generative models, in which a large number of time steps (inference steps) are required for a single image generation. To accelerate such tedious process, reducing steps uniformly is considered as an…

Computer Vision and Pattern Recognition · Computer Science 2023-09-26 Lijiang Li , Huixia Li , Xiawu Zheng , Jie Wu , Xuefeng Xiao , Rui Wang , Min Zheng , Xin Pan , Fei Chao , Rongrong Ji

Purely RGB-based vision models often fail to provide reliable cues in challenging scenarios such as nighttime and fog, leading to degraded performance and safety risks. Infrared imaging captures heat-emitting sources and provides critical…

Computer Vision and Pattern Recognition · Computer Science 2026-05-08 Yuchen Guo , Junli Gong , Wenjun Dong , Yiuming Cheung , Weifeng Su

Large denoising diffusion models, such as Stable Diffusion, have been trained on billions of image-caption pairs to perform text-conditioned image generation. As a byproduct of this training, these models have acquired general knowledge…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Alexandros Graikos , Nebojsa Jojic , Dimitris Samaras

Nuclei segmentation and classification is a significant process in pathology image analysis. Deep learning-based approaches have greatly contributed to the higher accuracy of this task. However, those approaches suffer from the imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Hyun-Jic Oh , Won-Ki Jeong

Conformal inference is a statistical method used to construct prediction sets for point predictors, providing reliable uncertainty quantification with probability guarantees. This method utilizes historical labeled data to estimate the…

Machine Learning · Computer Science 2024-11-05 Xiaoyi Su , Zhixin Zhou , Rui Luo

Diffusion models have shown remarkable performance in generation problems over various domains including images, videos, text, and audio. A practical bottleneck of diffusion models is their sampling speed, due to the repeated evaluation of…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Taehong Moon , Moonseok Choi , EungGu Yun , Jongmin Yoon , Gayoung Lee , Jaewoong Cho , Juho Lee

Denoising diffusion bridge models (DDBMs) are a powerful variant of diffusion models for interpolating between two arbitrary paired distributions given as endpoints. Despite their promising performance in tasks like image translation, DDBMs…

Machine Learning · Computer Science 2025-05-01 Kaiwen Zheng , Guande He , Jianfei Chen , Fan Bao , Jun Zhu

We introduce a fine-grained framework for uncertainty quantification of predictive models under distributional shifts. This framework distinguishes the shift in covariate distributions from that in the conditional relationship between the…

Methodology · Statistics 2025-05-20 Jiahao Ai , Zhimei Ren

Image completion is a challenging task, particularly when ensuring that generated content seamlessly integrates with existing parts of an image. While recent diffusion models have shown promise, they often struggle with maintaining…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Pourya Shamsolmoali , Masoumeh Zareapoor , Huiyu Zhou , Michael Felsberg , Dacheng Tao , Xuelong Li

Diffusion models produce impressive results in modalities ranging from images and video to protein design and text. However, generating samples with user-specified properties remains a challenge. Recent research proposes fine-tuning models…

Machine Learning · Computer Science 2025-07-21 Raghav Singhal , Zachary Horvitz , Ryan Teehan , Mengye Ren , Zhou Yu , Kathleen McKeown , Rajesh Ranganath

Cloth manipulation is challenging due to its highly complex dynamics, near-infinite degrees of freedom, and frequent self-occlusions, which complicate both state estimation and dynamics modeling. Inspired by recent advances in generative…

Robotics · Computer Science 2025-09-03 Tongxuan Tian , Haoyang Li , Bo Ai , Xiaodi Yuan , Zhiao Huang , Hao Su