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Graph Transformers (GTs), which integrate message passing and self-attention mechanisms simultaneously, have achieved promising empirical results in graph prediction tasks. However, the design of scalable and topology-aware node…

Neural and Evolutionary Computing · Computer Science 2025-12-12 Huizhe Zhang , Jintang Li , Yuchang Zhu , Huazhen Zhong , Liang Chen

Spiking neural networks (SNNs), inspired by the spiking behavior of biological neurons, offer a distinctive approach for capturing the complexities of temporal data. However, their potential for spatial modeling in multivariate time-series…

Machine Learning · Computer Science 2025-08-19 Bang Hu , Changze Lv , Mingjie Li , Yunpeng Liu , Xiaoqing Zheng , Fengzhe Zhang , Wei cao , Fan Zhang

Spiking neural networks (SNNs) exhibit temporal, sparse, and event-driven dynamics that make them appealing for efficient inference. However, extending these models to self-supervised regimes remains challenging because the discontinuities…

Emerging Technologies · Computer Science 2025-11-25 Chengwei Zhou , Gourav Datta

Single-cell RNA sequencing (scRNA-seq) data analysis is pivotal for understanding cellular heterogeneity. However, the high sparsity and complex noise patterns inherent in scRNA-seq data present significant challenges for traditional…

Genomics · Quantitative Biology 2024-08-13 Wenwen Min , Zhen Wang , Fangfang Zhu , Taosheng Xu , Shunfang Wang

While recent advancements in Large Language Models have significantly advanced dermatological diagnosis, monolithic LLMs frequently struggle with fine-grained, large-scale multi-class diagnostic tasks and rare skin disease diagnosis owing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Zhangtianyi Chen , Yuhao Shen , Florensia Widjaja , Yan Xu , Liyuan Sun , Zijian Wang , Hongyi Chen , Wufei Dai , Juexiao Zhou

We present the use of single-cell entropy (scEntropy) to measure the order of the cellular transcriptome profile from single-cell RNA-seq data, which leads to a method of unsupervised cell type classification through scEntropy followed by…

Quantitative Methods · Quantitative Biology 2020-02-18 Jingxin Liu , You Song , Jinzhi Lei

Fine-grained Entity Typing is a tough task which suffers from noise samples extracted from distant supervision. Thousands of manually annotated samples can achieve greater performance than millions of samples generated by the previous…

Artificial Intelligence · Computer Science 2019-06-14 Sheng Lin , Luye Zheng , Bo Chen , Siliang Tang , Yueting Zhuang , Fei Wu , Zhigang Chen , Guoping Hu , Xiang Ren

Single-cell RNA sequencing has transformed our ability to identify diverse cell types and their transcriptomic signatures. However, annotating these signatures-especially those involving poorly characterized genes-remains a major challenge.…

In recent years, the field of single-cell data analysis has seen a marked advancement in the development of clustering methods. Despite advancements, most of these algorithms still concentrate on analyzing the provided single-cell matrix…

Machine Learning · Computer Science 2023-12-18 Dayu Hu , Ke Liang , Hao Yu , Xinwang Liu

We present a systematic evaluation framework - thirty-seven analyses, 153 statistical tests, four cell types, two perturbation modalities - for assessing mechanistic interpretability in single-cell foundation models. Applying this framework…

Genomics · Quantitative Biology 2026-02-20 Ihor Kendiukhov

Clustering analysis is fundamental in single-cell RNA sequencing (scRNA-seq) data analysis for elucidating cellular heterogeneity and diversity. Recent graph-based scRNA-seq clustering methods, particularly graph neural networks (GNNs),…

Machine Learning · Computer Science 2025-07-15 Ping Xu , Pengfei Wang , Zhiyuan Ning , Meng Xiao , Min Wu , Yuanchun Zhou

The integration of self-attention mechanisms into Spiking Neural Networks (SNNs) has garnered considerable interest in the realm of advanced deep learning, primarily due to their biological properties. Recent advancements in SNN…

Neural and Evolutionary Computing · Computer Science 2023-06-02 Kaiwei Che , Zhaokun Zhou , Zhengyu Ma , Wei Fang , Yanqi Chen , Shuaijie Shen , Li Yuan , Yonghong Tian

Cytometry enables precise single-cell phenotyping within heterogeneous populations. These cell types are traditionally annotated via manual gating, but this method suffers from a lack of reproducibility and sensitivity to batch-effect.…

Action recognition is an exciting research avenue for artificial intelligence since it may be a game changer in the emerging industrial fields such as robotic visions and automobiles. However, current deep learning faces major challenges…

Computer Vision and Pattern Recognition · Computer Science 2022-06-08 Zihao Zhao , Yanhong Wang , Qiaosha Zou , Tie Xu , Fangbo Tao , Jiansong Zhang , Xiaoan Wang , C. -J. Richard Shi , Junwen Luo , Yuan Xie

As the third-generation neural network, the Spiking Neural Network (SNN) has the advantages of low power consumption and high energy efficiency, making it suitable for implementation on edge devices. More recently, the most advanced SNN,…

Computer Vision and Pattern Recognition · Computer Science 2023-11-16 Yue Liu , Shanlin Xiao , Bo Li , Zhiyi Yu

Spike-based encoders represent information as sequences of spikes or pulses, which are transmitted between neurons. A prevailing consensus suggests that spike-based approaches demonstrate exceptional capabilities in capturing the temporal…

Signal Processing · Electrical Eng. & Systems 2025-06-03 MHD Anas Alsakkal , Runze Wang , Jayawan Wijekoon , Huajin Tang

Spiking Neural Networks (SNNs), particularly Spiking Transformers, offer energy-efficient processing of event-based sensor data for healthcare applications. Yet current architectures are rigid: they are trained and deployed as static…

Neural and Evolutionary Computing · Computer Science 2026-05-15 Alberto Ancilotto , Gianluca Amprimo , Stefano Di Carlo , Elisabetta Farella

Spiking neural networks (SNNs) offer a promising energy-efficient alternative to artificial neural networks, due to their event-driven spiking computation. However, some foundation SNN backbones (including Spikformer and SEW ResNet) suffer…

Neural and Evolutionary Computing · Computer Science 2025-11-14 Chenlin Zhou , Liutao Yu , Zhaokun Zhou , Han Zhang , Jiaqi Wang , Huihui Zhou , Zhengyu Ma , Yonghong Tian

The remarkable success of foundation models has sparked growing interest in their application to single-cell biology. Models like Geneformer and scGPT promise to serve as versatile tools in this specialized field. However, representing a…

Quantitative Methods · Quantitative Biology 2024-11-12 Jiabei Cheng , Jiachen Li , Kaiyuan Yang , Hongbin Shen , Ye Yuan

Edge-cloud co-inference enables efficient deep neural network (DNN) deployment by splitting the architecture between an edge device and cloud server, crucial for resource-constraint edge devices. This approach requires balancing on-device…

Computer Vision and Pattern Recognition · Computer Science 2024-11-08 Maruf Hassan , Steven Davy