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Purpose: Demonstrating and assessing self-supervised machine learning fitting of the VERDICT (Vascular, Extracellular and Restricted DIffusion for Cytometry in Tumours) model for prostate. Methods: We derive a self-supervised neural network…

Image and Video Processing · Electrical Eng. & Systems 2023-09-28 Snigdha Sen , Saurabh Singh , Hayley Pye , Caroline M. Moore , Hayley Whitaker , Shonit Punwani , David Atkinson , Eleftheria Panagiotaki , Paddy J. Slator

This work aims to characterise renal tumour microstructure using diffusion MRI (dMRI); via the Vascular, Extracellular and Restricted Diffusion for Cytometry in Tumours (VERDICT)-MRI framework with self-supervised learning. Comprehensive…

Image and Video Processing · Electrical Eng. & Systems 2025-04-17 Snigdha Sen , Lorna Smith , Lucy Caselton , Joey Clemente , Maxine Tran , Shonit Punwani , David Atkinson , Richard L Hesketh , Eleftheria Panagiotaki

Diffusion magnetic resonance imaging (dMRI) is a crucial non-invasive technique for exploring the microstructure of the living human brain. Traditional hand-crafted and model-based tissue microstructure reconstruction methods often require…

Image and Video Processing · Electrical Eng. & Systems 2025-02-26 Xinrui Ma , Jian Cheng , Wenxin Fan , Ruoyou Wu , Yongquan Ye , Shanshan Wang

Diffusion models have recently gained popularity for accelerated MRI reconstruction due to their high sample quality. They can effectively serve as rich data priors while incorporating the forward model flexibly at inference time, and they…

Image and Video Processing · Electrical Eng. & Systems 2023-10-20 Batu Ozturkler , Chao Liu , Benjamin Eckart , Morteza Mardani , Jiaming Song , Jan Kautz

High-resolution diffusion tensor imaging (DTI) is beneficial for probing tissue microstructure in fine neuroanatomical structures, but long scan times and limited signal-to-noise ratio pose significant barriers to acquiring DTI at…

Image and Video Processing · Electrical Eng. & Systems 2021-02-19 Qiyuan Tian , Ziyu Li , Qiuyun Fan , Chanon Ngamsombat , Yuxin Hu , Congyu Liao , Fuyixue Wang , Kawin Setsompop , Jonathan R. Polimeni , Berkin Bilgic , Susie Y. Huang

Deep learning-based analysis of high-frequency, high-resolution micro-ultrasound data shows great promise for prostate cancer detection. Previous approaches to analysis of ultrasound data largely follow a supervised learning paradigm.…

Image and Video Processing · Electrical Eng. & Systems 2022-11-02 Paul F. R. Wilson , Mahdi Gilany , Amoon Jamzad , Fahimeh Fooladgar , Minh Nguyen Nhat To , Brian Wodlinger , Purang Abolmaesumi , Parvin Mousavi

Diffusion MRI is a non-invasive, in-vivo biomedical imaging method for mapping tissue microstructure. Applications include structural connectivity imaging of the human brain and detecting microstructural neural changes. However, acquiring…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Amir Sadikov , Xinlei Pan , Hannah Choi , Lanya T. Cai , Pratik Mukherjee

Latent Diffusion Models (LDMs) can generate high-fidelity images from noise, offering a promising approach for augmenting histopathology images for training cancer grading models. While previous works successfully generated high-fidelity…

Image and Video Processing · Electrical Eng. & Systems 2024-04-23 Man M. Ho , Elham Ghelichkhan , Yosep Chong , Yufei Zhou , Beatrice Knudsen , Tolga Tasdizen

Dose escalation radiotherapy allows increased control of prostate cancer (PCa) but requires segmentation of dominant index lesions (DIL), motivating the development of automated methods for fast, accurate, and consistent segmentation of PCa…

Image and Video Processing · Electrical Eng. & Systems 2023-03-08 Josiah Simeth , Jue Jiang , Anton Nosov , Andreas Wibmer , Michael Zelefsky , Neelam Tyagi , Harini Veeraraghavan

Deep learning models (DLMs) can achieve state-of-the-art performance in histopathology image segmentation and classification, but have limited deployment potential in real-world clinical settings. Uncertainty estimates of DLMs can increase…

Image and Video Processing · Electrical Eng. & Systems 2024-12-31 Audrey Xie , Elhoucine Elfatimi , Sambuddha Ghosal , Pratik Shah

Breast-Conserving Surgery (BCS) requires precise intraoperative margin assessment to preserve healthy tissue. Deep Ultraviolet Fluorescence Scanning Microscopy (DUV-FSM) offers rapid, high-resolution surface imaging for this purpose;…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Pouya Afshin , David Helminiak , Tianling Niu , Julie M. Jorns , Tina Yen , Bing Yu , Dong Hye Ye

Accurate prostate cancer diagnosis remains challenging. Even when using MRI, radiologists exhibit low specificity and significant inter-observer variability, leading to potential delays or inaccuracies in identifying clinically significant…

Current deep learning approaches for prostate cancer lesion segmentation achieve limited performance, with Dice scores of 0.32 or lower in large patient cohorts. To address this limitation, we investigate synthetic correlated diffusion…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Jarett Dewbury , Chi-en Amy Tai , Alexander Wong

Ultrasound (US) imaging is clinically invaluable due to its noninvasive and safe nature. However, interpreting US images is challenging, requires significant expertise, and time, and is often prone to errors. Deep learning offers assistive…

Computer Vision and Pattern Recognition · Computer Science 2025-02-05 Edward Ellis , Andrew Bulpitt , Nasim Parsa , Michael F Byrne , Sharib Ali

Purpose: Diffusion MRI has shown promise for breast cancer screening, lesion characterization,and treatment response monitoring without contrast agents, but further translation is constraint by the gradient performance of conventional…

Medical Physics · Physics 2026-05-12 Gerrit Arends , Edwin Versteeg , Feng Jia , Dennis Klomp , Maxim Zaitsev , Sebastian Littin , Chantal Tax

Diffusion magnetic resonance imaging (dMRI) plays a vital role in both clinical diagnostics and neuroscience research. However, its inherently low signal-to-noise ratio (SNR), especially under high diffusion weighting, significantly…

Quantitative Methods · Quantitative Biology 2026-02-27 Jine Xie , Zhicheng Zhang , Yunwei Chen , Yanqiu Feng , Xinyuan Zhang

We present Distortion-Guided Restoration (DGR), a physics-informed hybrid CNN-diffusion framework for acquisition-free correction of severe susceptibility-induced distortions in prostate single-shot EPI diffusion-weighted imaging (DWI). DGR…

Image and Video Processing · Electrical Eng. & Systems 2026-04-02 Ziyang Long , Binesh Nader , Lixia Wang , Archana Vadiraj Malaji , Chia-Chi Yang , Haoran Sun , Rola Saouaf , Timothy Daskivich , Hyung Kim , Yibin Xie , Debiao Li , Hsin-Jung Yang

Breast ultrasound (US) is an effective imaging modality for breast cancer detection and diagnosis. US computer-aided diagnosis (CAD) systems have been developed for decades and have employed either conventional hand-crafted features or…

Medical Physics · Physics 2020-03-12 Erlei Zhang , Stephen Seiler , Mingli Chen , Weiguo Lu , Xuejun Gu

Prostate cancer is a dominant health concern calling for advanced diagnostic tools. Utilizing digital pathology and artificial intelligence, this study explores the potential of 11 deep neural network architectures for automated Gleason…

Robust self-training (RST) can augment the adversarial robustness of image classification models without significantly sacrificing models' generalizability. However, RST and other state-of-the-art defense approaches failed to preserve the…

Image and Video Processing · Electrical Eng. & Systems 2022-05-05 Shoukun Sun , Min Xian , Aleksandar Vakanski , Hossny Ghanem
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