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The integration of Artificial Intelligence (AI), especially Large Language Models (LLMs), into the clinical diagnosis process offers significant potential to improve the efficiency and accessibility of medical care. While LLMs have shown…

Computation and Language · Computer Science 2024-10-15 Mingyu Derek Ma , Chenchen Ye , Yu Yan , Xiaoxuan Wang , Peipei Ping , Timothy S Chang , Wei Wang

Machine learning can precisely identify different cancer tumors at any stage by classifying cancerous and healthy samples based on their genomic profile. We have developed novel methods of MLAC (Machine Learning Against Cancer) achieving…

Genomics · Quantitative Biology 2020-09-15 Arash Hooshmand

Obtaining standardized crowdsourced benchmark of computational methods is a major issue in data science communities. Dedicated frameworks enabling fair benchmarking in a unified environment are yet to be developed. Here we introduce…

Machine Learning · Computer Science 2022-06-28 Zhen Xu , Sergio Escalera , Isabelle Guyon , Adrien Pavão , Magali Richard , Wei-Wei Tu , Quanming Yao , Huan Zhao

Single-cell RNA sequencing (scRNA-seq) enables the study of cellular diversity at single cell level. It provides a global view of cell-type specification during the onset of biological mechanisms such as developmental processes and human…

Machine Learning · Computer Science 2025-11-05 Muhammad Umar , Andras Lakatos , Muhammad Asif , Arif Mahmood

As LLM agents are increasingly built around reusable skills, a central challenge is no longer only whether agents can use provided skills, but whether they can generate correct, reusable, and executable skills from repositories and…

Artificial Intelligence · Computer Science 2026-05-19 Yifan Zhou , Zhentao Zhang , Ziming Cheng , Shuo Zhang , Qizhen Lan , Zhangquan Chen , Zhi Yang , QianyuXu , Ronghao Chen , Huacan Wang , Sen Hu

Given a long list of anomaly detection algorithms developed in the last few decades, how do they perform with regard to (i) varying levels of supervision, (ii) different types of anomalies, and (iii) noisy and corrupted data? In this work,…

Machine Learning · Computer Science 2022-09-20 Songqiao Han , Xiyang Hu , Hailiang Huang , Mingqi Jiang , Yue Zhao

Modern high-throughput single-cell immune profiling technologies, such as flow and mass cytometry and single-cell RNA sequencing can readily measure the expression of a large number of protein or gene features across the millions of cells…

Quantitative Methods · Quantitative Biology 2022-07-05 Vishal Athreya Baskaran , Jolene Ranek , Siyuan Shan , Natalie Stanley , Junier B. Oliva

Single-cell RNA sequencing (scRNA-seq) enables single-cell transcriptomic profiling, revealing cellular heterogeneity and rare populations. Recent deep learning models like Geneformer and Mouse-Geneformer perform well on tasks such as…

Genomics · Quantitative Biology 2025-07-11 Yuki Nishio , Takayoshi Yamashita , Keita Ito , Tsubasa Hirakawa , Hironobu Fujiyoshi

Most of the existing Large Language Model (LLM) benchmarks on scientific problem reasoning focus on problems grounded in high-school subjects and are confined to elementary algebraic operations. To systematically examine the reasoning…

Computation and Language · Computer Science 2024-07-01 Xiaoxuan Wang , Ziniu Hu , Pan Lu , Yanqiao Zhu , Jieyu Zhang , Satyen Subramaniam , Arjun R. Loomba , Shichang Zhang , Yizhou Sun , Wei Wang

Human placenta is a complex and heterogeneous organ interfacing between the mother and the fetus that supports fetal development. Alterations to placental structural components are associated with various pregnancy complications. To reveal…

Tissues and Organs · Quantitative Biology 2020-08-11 Hui Li , Qianhui Huang , Yu Liu , Lana X Garmire

Data-based classification is fundamental to most branches of science. While recent years have brought enormous progress in various areas of statistical computing and clustering, some general challenges in clustering remain: model selection,…

Artificial Intelligence · Computer Science 2007-06-13 Jens Oehlschlägel

Semi-supervised clustering is the task of clustering data points into clusters where only a fraction of the points are labelled. The true number of clusters in the data is often unknown and most models require this parameter as an input.…

Machine Learning · Computer Science 2013-09-27 Amar Shah , Zoubin Ghahramani

Experimental evaluation is a major research methodology for investigating clustering algorithms and many other machine learning algorithms. For this purpose, a number of benchmark datasets have been widely used in the literature and their…

Machine Learning · Computer Science 2019-10-21 Tiantian Zhang , Li Zhong , Bo Yuan

The performance of supervised classification techniques often deteriorates when the data has noisy labels. Even the semi-supervised classification approaches have largely focused only on the problem of handling missing labels. Most of the…

Machine Learning · Computer Science 2022-05-05 Ashit Gupta , Anirudh Deodhar , Tathagata Mukherjee , Venkataramana Runkana

Clustering has long been a popular unsupervised learning approach to identify groups of similar objects and discover patterns from unlabeled data in many applications. Yet, coming up with meaningful interpretations of the estimated clusters…

Methodology · Statistics 2020-05-26 Minjie Wang , Tianyi Yao , Genevera I. Allen

Cell segmentation is a critical step for quantitative single-cell analysis in microscopy images. Existing cell segmentation methods are often tailored to specific modalities or require manual interventions to specify hyper-parameters in…

The breakthrough in Deep Learning neural networks has transformed the use of AI and machine learning technologies for the analysis of very large experimental datasets. These datasets are typically generated by large-scale experimental…

Machine Learning · Computer Science 2021-10-26 Jeyan Thiyagalingam , Mallikarjun Shankar , Geoffrey Fox , Tony Hey

Seed science is essential for modern agriculture, directly influencing crop yields and global food security. However, challenges such as interdisciplinary complexity and high costs with limited returns hinder progress, leading to a shortage…

Computation and Language · Computer Science 2025-05-20 Jie Ying , Zihong Chen , Zhefan Wang , Wanli Jiang , Chenyang Wang , Zhonghang Yuan , Haoyang Su , Huanjun Kong , Fan Yang , Nanqing Dong

The segmentation of medical images is a fundamental step in automated clinical decision support systems. Existing medical image segmentation methods based on supervised deep learning, however, remain problematic because of their reliance on…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Euijoon Ahn , Dagan Feng , Jinman Kim

Learning multimodal representations involves integrating information from multiple heterogeneous sources of data. It is a challenging yet crucial area with numerous real-world applications in multimedia, affective computing, robotics,…

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