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Optical coherence tomography (OCT) is a non-invasive imaging technique with extensive clinical applications in ophthalmology. OCT enables the visualization of the retinal layers, playing a vital role in the early detection and monitoring of…

In ophthalmology, intravitreal operative medication therapy (IVOM) is a widespread treatment for diseases related to the age-related macular degeneration (AMD), the diabetic macular edema (DME), as well as the retinal vein occlusion (RVO).…

Image and Video Processing · Electrical Eng. & Systems 2024-10-03 Tobias Schlosser , Frederik Beuth , Trixy Meyer , Arunodhayan Sampath Kumar , Gabriel Stolze , Olga Furashova , Katrin Engelmann , Danny Kowerko

Retinal neovascularization (RNV) is a vision threatening development in diabetic retinopathy (DR). Vision loss associated with RNV is preventable with timely intervention, making RNV clinical screening and monitoring a priority. Optical…

Image and Video Processing · Electrical Eng. & Systems 2026-04-01 Jinyi Hao , Jie Wang , Liqin Gao , Tristan T. Hormel , Yukun Guo , An-Lun Wu , Christina J. Flaxel , Steven T. Bailey , Kotaro Tsuboi , Thomas S. Hwang , Yali Jia

Visual explanation methods have an important role in the prognosis of the patients where the annotated data is limited or unavailable. There have been several attempts to use gradient-based attribution methods to localize pathology from…

Image and Video Processing · Electrical Eng. & Systems 2021-06-24 Ugur Demir , Ismail Irmakci , Elif Keles , Ahmet Topcu , Ziyue Xu , Concetto Spampinato , Sachin Jambawalikar , Evrim Turkbey , Baris Turkbey , Ulas Bagci

The analysis of retinal images for the diagnosis of various diseases is one of the emerging areas of research. Recently, the research direction has been inclined towards investigating several changes in retinal blood vessels in subjects…

Image and Video Processing · Electrical Eng. & Systems 2024-12-10 Mehwish Mehmood , Shahzaib Iqbal , Tariq Mahmood Khan , Ivor Spence , Muhammad Fahim

It is feasible to recognize the presence and seriousness of eye disease by investigating the progressions in retinal biological structure. Fundus examination is a diagnostic procedure to examine the biological structure and anomaly of the…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Amit Bhati , Neha Gour , Pritee Khanna , Aparajita Ojha

This paper presents a novel framework, named Global-Local Correspondence Framework (GLCF), for visual anomaly detection with logical constraints. Visual anomaly detection has become an active research area in various real-world…

Computer Vision and Pattern Recognition · Computer Science 2023-03-30 Haiming Yao , Wenyong Yu , Wei Luo , Zhenfeng Qiang , Donghao Luo , Xiaotian Zhang

Cancerous skin lesions are one of the most common malignancies detected in humans, and if not detected at an early stage, they can lead to death. Therefore, it is crucial to have access to accurate results early on to optimize the chances…

Image and Video Processing · Electrical Eng. & Systems 2023-05-19 Daniel Alonso Villanueva Nunez , Yongmin Li

The microscopic examination of surgical tissue remains a cornerstone of disease classification but relies on subjective interpretations and access to highly specialized experts, which can compromise accuracy and clinical care. While…

Computer-generated holographic (CGH) displays show great potential and are emerging as the next-generation displays for augmented and virtual reality, and automotive heads-up displays. One of the critical problems harming the wide adoption…

Human-Computer Interaction · Computer Science 2021-08-16 Praneeth Chakravarthula , Zhan Zhang , Okan Tursun , Piotr Didyk , Qi Sun , Henry Fuchs

Age-related macular degeneration (AMD) is the most common cause of blindness in developed countries, especially in people over 60 years of age. The workload of specialists and the healthcare system in this field has increased in recent…

Image and Video Processing · Electrical Eng. & Systems 2022-02-07 Saman Sotoudeh-Paima , Ata Jodeiri , Fedra Hajizadeh , Hamid Soltanian-Zadeh

Deep learning has enabled breakthroughs in automated diagnosis from medical imaging, with many successful applications in ophthalmology. However, standard medical image classification approaches only assess disease presence at the time of…

Computer Vision and Pattern Recognition · Computer Science 2024-07-31 Gregory Holste , Mingquan Lin , Ruiwen Zhou , Fei Wang , Lei Liu , Qi Yan , Sarah H. Van Tassel , Kyle Kovacs , Emily Y. Chew , Zhiyong Lu , Zhangyang Wang , Yifan Peng

Hepatocellular carcinoma (HCC) is the second most frequent cause of malignancy-related death and is one of the diseases with the highest incidence in the world. Because the liver is the only organ in the human body that is supplied by two…

Computer Vision and Pattern Recognition · Computer Science 2019-07-25 Jiechao Ma , Yingqian Chen , Yu Chen , Fengkai Wan , Sumin Xue , Ziping Li , Shiting Feng

Diabetic retinopathy (DR) is a leading cause of blindness worldwide, necessitating early detection to prevent vision loss. Current automated DR detection systems often struggle with poor-quality images, lack interpretability, and…

Image and Video Processing · Electrical Eng. & Systems 2025-09-03 Idowu Paul Okuwobi , Jingyuan Liu , Jifeng Wan , Jiaojiao Jiang

In this manuscript, we present a robust method for glaucoma screening from fundus images using an ensemble of convolutional neural networks (CNNs). The pipeline comprises of first segmenting the optic disk and optic cup from the fundus…

Computer Vision and Pattern Recognition · Computer Science 2018-09-17 Vismay Agrawal , Avinash Kori , Varghese Alex , Ganapathy Krishnamurthi

Background/Objectives: Age-related macular degeneration, glaucoma, diabetic retinopathy (DR), diabetic macular edema, and pathological myopia affect hundreds of millions of people worldwide. Early screening for these diseases is essential,…

Image and Video Processing · Electrical Eng. & Systems 2025-07-18 Ananya Raghu , Anisha Raghu , Alice S. Tang , Yannis M. Paulus , Tyson N. Kim , Tomiko T. Oskotsky

Invasive ductal carcinoma (IDC) is the most prevalent form of breast cancer, and early, accurate diagnosis is critical to improving patient survival rates by guiding treatment decisions. Combining medical expertise with artificial…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Shuo Han , Ahmed Karam Eldaly , Solomon Sunday Oyelere

Diabetic retinopathy (DR) is a leading cause of blindness worldwide, and AI systems can expand access to fundus photography screening. Current FDA-cleared systems primarily provide binary referral outputs, where this minimal output may…

Artificial Intelligence · Computer Science 2025-09-17 Nadim Barakat , William Lotter

The utilization of longitudinal datasets for glaucoma progression prediction offers a compelling approach to support early therapeutic interventions. Predominant methodologies in this domain have primarily focused on the direct prediction…

Computer Vision and Pattern Recognition · Computer Science 2024-11-06 Zhihao Zhao , Junjie Yang , Shahrooz Faghihroohi , Yinzheng Zhao , Daniel Zapp , Kai Huang , Nassir Navab , M. Ali Nasseri

Due to its safety-critical property, the image-based diagnosis is desired to achieve robustness on out-of-distribution (OOD) samples. A natural way towards this goal is capturing only clinically disease-related features, which is composed…

Computer Vision and Pattern Recognition · Computer Science 2022-04-22 Churan Wang , Jing Li , Xinwei Sun , Fandong Zhang , Yizhou Yu , Yizhou Wang
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