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Classifying chemicals according to putative modes of action (MOAs) is of paramount importance in the context of risk assessment. However, current methods are only able to handle a very small proportion of the existing chemicals. We address…

Quantitative Methods · Quantitative Biology 2018-11-28 Cătălina Cangea , Arturas Grauslys , Pietro Liò , Francesco Falciani

Wireless sensor networks require accurate target localization, often achieved through received signal strength (RSS) localization estimation based on maximum likelihood (ML). However, ML-based algorithms can suffer from issues such as low…

Signal Processing · Electrical Eng. & Systems 2023-07-25 Weizhong Ding , Shengming Chang , Shudi Bao , Meng Chen , Jie Sun

Molecular representations are inherently task-dependent, yet most pre-trained molecular encoders are not. Task conditioning promises representations that reorganize based on task descriptions, but existing approaches rely on expensive…

Chemical Physics · Physics 2026-02-05 Gordan Prastalo , Kevin Maik Jablonka

In recent years machine learning (ML) took bio- and cheminformatics fields by storm, providing new solutions for a vast repertoire of problems related to protein sequence, structure, and interactions analysis. ML techniques, deep neural…

Biomolecules · Quantitative Biology 2020-03-31 Marta M. Stepniewska-Dziubinska , Piotr Zielenkiewicz , Pawel Siedlecki

Choosing a suitable deep learning architecture for multimodal data fusion is a challenging task, as it requires the effective integration and processing of diverse data types, each with distinct structures and characteristics. In this…

Machine Learning · Computer Science 2025-01-22 Abdelmadjid Chergui , Grigor Bezirganyan , Sana Sellami , Laure Berti-Équille , Sébastien Fournier

To address the extremely concerning problem of software vulnerability, system security is often entrusted to Machine Learning (ML) algorithms. Despite their now established detection capabilities, such models are limited by design to…

Machine Learning · Computer Science 2025-10-14 Marco Pintore , Giorgio Piras , Angelo Sotgiu , Maura Pintor , Battista Biggio

We initiate the study of numerical linear algebra in the sliding window model, where only the most recent $W$ updates in a stream form the underlying data set. We first introduce a unified row-sampling based framework that gives randomized…

Data Structures and Algorithms · Computer Science 2023-04-12 Vladimir Braverman , Petros Drineas , Cameron Musco , Christopher Musco , Jalaj Upadhyay , David P. Woodruff , Samson Zhou

We study two mixed robust/average-case submodular partitioning problems that we collectively call Submodular Partitioning. These problems generalize both purely robust instances of the problem (namely max-min submodular fair allocation…

Data Structures and Algorithms · Computer Science 2016-08-17 Kai Wei , Rishabh Iyer , Shengjie Wang , Wenruo Bai , Jeff Bilmes

Developing effective surrogates (performance predictors) for Neural Architecture Search (NAS) typically requires expensive fine-tuning or the engineering of complex representations. We propose a low-cost embedding strategy that leverages…

Machine Learning · Computer Science 2026-05-18 Pranav Somu , Advay Balakrishnan , Stepan Kravtsov , Aaron McDaniel , Jason Zutty

The significant advancements of Large Language Models (LLMs) in generative tasks have led to a growing body of work exploring LLM-based embedding models. While these models, employing different pooling and attention strategies, have…

Computation and Language · Computer Science 2024-09-06 Yixuan Tang , Yi Yang

Machine learning (ML) offers considerable promise for the design of new molecules and materials. In real-world applications, the design problem is often domain-specific, and suffers from insufficient data, particularly labeled data, for ML…

Chemical Physics · Physics 2025-02-04 Ming Han , Ge Sun , Juan J. de Pablo

Algorithm selection (AS) deals with selecting an algorithm from a fixed set of candidate algorithms most suitable for a specific instance of an algorithmic problem, e.g., choosing solvers for SAT problems. Benchmark suites for AS usually…

Machine Learning · Computer Science 2020-10-23 Alexander Tornede , Marcel Wever , Eyke Hüllermeier

The performance of automated algorithm selection (AAS) strongly depends on the portfolio of algorithms to choose from. Selecting the portfolio is a non-trivial task that requires balancing the trade-off between the higher flexibility of…

Analytical join queries over unstructured data are increasingly prevalent in data analytics. Applying machine learning (ML) models to label every pair in the cross product of tables can achieve state-of-the-art accuracy, but the cost of…

Databases · Computer Science 2026-03-18 Yuxuan Zhu , Tengjun Jin , Chenghao Mo , Daniel Kang

This paper presents the methods that have participated in the SHREC 2022 contest on protein-ligand binding site recognition. The prediction of protein-ligand binding regions is an active research domain in computational biophysics and…

A multitude of measures have been proposed to quantify the similarity between protein 3-D structure. Among these measures, contact map overlap (CMO) maximization deserved sustained attention during past decade because it offers a fine…

Quantitative Methods · Quantitative Biology 2009-04-20 Rumen Andonov , Nicola Yanev , Noël Malod-Dognin

Recent advancements in protein docking site prediction have highlighted the limitations of traditional rigid docking algorithms, like PIPER, which often neglect critical stochastic elements such as solvent-induced fluctuations. These…

Quantitative Methods · Quantitative Biology 2024-12-02 Nanjie Chen , Dongliang Yu , Dmitri Beglov , Mark Kon , Julio Enrique Castrillon-Candas

Recent studies on neural architecture search have shown that automatically designed neural networks perform as good as expert-crafted architectures. While most existing works aim at finding architectures that optimize the prediction…

The development of machine-learning (ML) potentials offers significant accuracy improvements compared to molecular mechanics (MM) because of the inclusion of quantum-mechanical effects in molecular interactions. However, ML simulations are…

Single-cell sequencing is revolutionizing biology by enabling detailed investigations of cell-state transitions. Many biological processes unfold along continuous trajectories, yet it remains challenging to extract smooth, low-dimensional…

Machine Learning · Statistics 2025-06-30 Rong Ma , Xi Li , Jingyuan Hu , Bin Yu