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Large-language models (LLMs) are rapidly being applied to radiology, enabling automated image interpretation and report generation tasks. Their deployment in clinical practice requires both high diagnostic accuracy and low inference…

Tissues and Organs · Quantitative Biology 2025-11-11 Jyun-Ping Kao

Large Language Models (LLMs) excel in various natural language processing tasks, but leveraging them for dense passage embedding remains challenging. This is due to their causal attention mechanism and the misalignment between their…

Computation and Language · Computer Science 2024-08-08 Hieu Man , Nghia Trung Ngo , Franck Dernoncourt , Thien Huu Nguyen

Large language model (LLM) inference has been a prevalent demand in daily life and industries. The large tensor sizes and computing complexities in LLMs have brought challenges to memory, computing, and databus. This paper proposes a…

Hardware Architecture · Computer Science 2025-09-19 Yimin Wang , Yue Jiet Chong , Xuanyao Fong

Phase-change memory (PCM) devices have multiple banks to serve memory requests in parallel. Unfortunately, if two requests go to the same bank, they have to be served one after another, leading to lower system performance. We observe that a…

Hardware Architecture · Computer Science 2019-08-22 Shihao Song , Anup Das , Onur Mutlu , Nagarajan Kandasamy

The widespread adoption of LLMs has driven an exponential rise in their deployment, imposing substantial demands on inference clusters. These clusters must handle numerous concurrent queries for different LLM downstream tasks. To handle…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-14 Nikoleta Iliakopoulou , Jovan Stojkovic , Chloe Alverti , Tianyin Xu , Hubertus Franke , Josep Torrellas

Memory systems have been designed to leverage past experiences in Large Language Model (LLM) agents. However, many deployed memory systems primarily optimize compression and storage, with comparatively less emphasis on explicit, closed-loop…

Artificial Intelligence · Computer Science 2025-12-24 Xingbo Du , Loka Li , Duzhen Zhang , Le Song

In Scientific Computing and modern Machine Learning (ML) workloads, sequences of dependent General Matrix Multiplications (GEMMs) often dominate execution time. While state-of-the-art BLAS libraries aggressively optimize individual GEMM…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-07 César Guedes Carneiro , Lucas Alvarenga , Guido Araujo , Sandro Rigo

While Large Language Models (LLMs) have achieved remarkable success in various fields, the efficiency of training and inference remains a major challenge. To address this issue, we propose SUBLLM, short for Subsampling-Upsampling-Bypass…

Computation and Language · Computer Science 2024-08-26 Quandong Wang , Yuxuan Yuan , Xiaoyu Yang , Ruike Zhang , Kang Zhao , Wei Liu , Jian Luan , Daniel Povey , Bin Wang

Large Reasoning Models (LRMs) have shown promising accuracy improvements on complex problem-solving tasks. While these models have attained high accuracy by leveraging additional computation at test time, they need to generate long…

Computation and Language · Computer Science 2025-12-16 Coleman Hooper , Sebastian Zhao , Luca Manolache , Sehoon Kim , Michael W. Mahoney , Yakun Sophia Shao , Kurt Keutzer , Amir Gholami

The latest trends in high-performance computing systems show an increasing demand on the use of a large scale multicore systems in a efficient way, so that high compute-intensive applications can be executed reasonably well. However, the…

Distributed, Parallel, and Cluster Computing · Computer Science 2013-02-25 Juliana M. N. Silva , Cristina Boeres , Lúcia M. A. Drummond , Artur A. Pessoa

RowHammer (RH) is a significant and worsening security, safety, and reliability issue of modern DRAM chips that can be exploited to break memory isolation. Therefore, it is important to understand real DRAM chips' RH characteristics.…

Large Language Models (LLMs) have become increasingly popular, transforming a wide range of applications across various domains. However, the real-world effectiveness of their query cache systems has not been thoroughly investigated. In…

Computation and Language · Computer Science 2024-06-04 Jiaxing Li , Chi Xu , Feng Wang , Isaac M von Riedemann , Cong Zhang , Jiangchuan Liu

Processing-using-DRAM (PUD) architectures impose a restrictive data layout and alignment for their operands, where source and destination operands (i) must reside in the same DRAM subarray (i.e., a group of DRAM rows sharing the same row…

Hardware Architecture · Computer Science 2024-03-08 Geraldo F. Oliveira , Emanuele G. Esposito , Juan Gómez-Luna , Onur Mutlu

Processing long contexts presents a significant challenge for large language models (LLMs). While recent advancements allow LLMs to handle much longer contexts than before (e.g., 32K or 128K tokens), it is computationally expensive and can…

Computation and Language · Computer Science 2025-04-10 Hongjin Qian , Zheng Liu , Peitian Zhang , Kelong Mao , Defu Lian , Zhicheng Dou , Tiejun Huang

In modern systems, DRAM-based main memory is significantly slower than the processor. Consequently, processors spend a long time waiting to access data from main memory, making the long main memory access latency one of the most critical…

Hardware Architecture · Computer Science 2016-11-01 Donghyuk Lee

Mixture-of-Experts (MoE) has become a dominant architecture for scaling large language models (LLMs). However, the execution characteristics of MoE inference are changing rapidly and increasingly mismatch the assumptions underlying existing…

Hardware Architecture · Computer Science 2026-05-13 Jungwoo Kim , Rubens Lacouture , Genghan Zhang , Gina Sohn , Qizheng Zhang , Swapnil Gandhi , Christos Kozyrakis , Kunle Olukotun

Large language models (LLMs) excel in many natural language processing (NLP) tasks. However, since LLMs can only incorporate new knowledge through training or supervised fine-tuning processes, they are unsuitable for applications that…

Databases · Computer Science 2024-07-23 Zongyue Qin , Chen Luo , Zhengyang Wang , Haoming Jiang , Yizhou Sun

Deploying Large Language Models (LLMs) on resource-constrained devices remains challenging due to limited memory, lack of GPUs, and the complexity of existing runtimes. In this paper, we introduce TranSQL+, a template-based code generator…

Databases · Computer Science 2025-09-23 Wenbo Sun , Qiming Guo , Wenlu Wang , Rihan Hai

The rapid development of multi-core system and increase of data-intensive application in recent years call for larger main memory. Traditional DRAM memory can increase its capacity by reducing the feature size of storage cell. Now further…

Hardware Architecture · Computer Science 2016-06-13 Shenchen Ruan , Haixia Wang , Dongsheng Wang

In-DRAM Processing-In-Memory (DRAM-PIM) has emerged as a promising approach to accelerate memory-intensive workloads by mitigating data transfer overhead between DRAM and the host processor. Bit-serial DRAM-PIM architectures, further…

Hardware Architecture · Computer Science 2025-12-11 Siyuan Ma , Jiajun Hu , Jeeho Ryoo , Aman Arora , Lizy Kurian John