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Denoising Diffusion Models (DDMs) are widely used for high-quality image generation and medical image segmentation but often rely on Unet-based architectures, leading to high computational overhead, especially with high-resolution images.…

Computer Vision and Pattern Recognition · Computer Science 2025-01-07 Avni Mittal , John Kalkhof , Anirban Mukhopadhyay , Arnav Bhavsar

Recent progress in diffusion-based visual generation has largely relied on latent diffusion models with variational autoencoders (VAEs). While effective for high-fidelity synthesis, this VAE+diffusion paradigm suffers from limited training…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Minglei Shi , Haolin Wang , Wenzhao Zheng , Ziyang Yuan , Xiaoshi Wu , Xintao Wang , Pengfei Wan , Jie Zhou , Jiwen Lu

Diffusion models have been used extensively for high quality image and video generation tasks. In this paper, we propose a novel conditional diffusion model with spatial attention and latent embedding (cDAL) for medical image segmentation.…

Image and Video Processing · Electrical Eng. & Systems 2025-02-21 Behzad Hejrati , Soumyanil Banerjee , Carri Glide-Hurst , Ming Dong

Diffusion models have demonstrated their effectiveness across various generative tasks. However, when applied to medical image segmentation, these models encounter several challenges, including significant resource and time requirements.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Tianyu Lin , Zhiguang Chen , Zhonghao Yan , Weijiang Yu , Fudan Zheng

Latent Diffusion Models (LDM), a subclass of diffusion models, mitigate the computational complexity of pixel-space diffusion by operating within a compressed latent space constructed by Variational Autoencoders (VAEs), demonstrating…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Arpan Mahara , Md Rezaul Karim Khan , Naphtali Rishe , Wenjia Wang , Seyed Masoud Sadjadi

The scarcity of high-quality segmentation masks remains a major bottleneck for medical image analysis, particularly in non-contrast CT (NCCT) neuroimaging, where manual annotation is costly and variable. To address this limitation, we…

Image and Video Processing · Electrical Eng. & Systems 2026-02-12 Lucia Borrego , Vajira Thambawita , Marco Ciuffreda , Ines del Val , Alejandro Dominguez , Josep Munuera

Diffusion probabilistic models have been shown to generate state-of-the-art results on several competitive image synthesis benchmarks but lack a low-dimensional, interpretable latent space, and are slow at generation. On the other hand,…

Machine Learning · Computer Science 2022-11-30 Kushagra Pandey , Avideep Mukherjee , Piyush Rai , Abhishek Kumar

Latent diffusion models for medical image super-resolution universally inherit variational autoencoders designed for natural photographs. We show that this default choice, not the diffusion architecture, is the dominant constraint on…

In recent times, denoising diffusion probabilistic models (DPMs) have proven effective for medical image generation and denoising, and as representation learners for downstream segmentation. However, segmentation performance is limited by…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Venkata Siddharth Dhara , Pawan Kumar

Medical image segmentation plays a vital role in clinic disease diagnosis and medical image analysis. However, labeling medical images for segmentation task is tough due to the indispensable domain expertise of radiologists. Furthermore,…

Image and Video Processing · Electrical Eng. & Systems 2024-03-20 Yubin Zheng , Peng Tang , Tianjie Ju , Weidong Qiu , Bo Yan

Recent advancements in deep learning for medical image segmentation are often limited by the scarcity of high-quality training data.While diffusion models provide a potential solution by generating synthetic images, their effectiveness in…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Jianhao Xie , Ziang Zhang , Zhenyu Weng , Yuesheng Zhu , Guibo Luo

In-context segmentation has drawn increasing attention with the advent of vision foundation models. Its goal is to segment objects using given reference images. Most existing approaches adopt metric learning or masked image modeling to…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Chaoyang Wang , Xiangtai Li , Henghui Ding , Lu Qi , Jiangning Zhang , Yunhai Tong , Chen Change Loy , Shuicheng Yan

Accurate medical image segmentation is crucial for precise anatomical delineation. Deep learning models like U-Net have shown great success but depend heavily on large datasets and struggle with domain shifts, complex structures, and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Hantao Zhang , Yuhe Liu , Jiancheng Yang , Weidong Guo , Xinyuan Wang , Pascal Fua

This study presents Latent Diffusion Autoencoder (LDAE), a novel encoder-decoder diffusion-based framework for efficient and meaningful unsupervised learning in medical imaging, focusing on Alzheimer disease (AD) using brain MR from the…

Computer Vision and Pattern Recognition · Computer Science 2026-01-12 Gabriele Lozupone , Alessandro Bria , Francesco Fontanella , Frederick J. A. Meijer , Claudio De Stefano , Henkjan Huisman

In recent years, Denoising Diffusion Models have demonstrated remarkable success in generating semantically valuable pixel-wise representations for image generative modeling. In this study, we propose a novel end-to-end framework, called…

Image and Video Processing · Electrical Eng. & Systems 2023-03-21 Zhaohu Xing , Liang Wan , Huazhu Fu , Guang Yang , Lei Zhu

Solving medical imaging data scarcity through semantic image generation has attracted growing attention in recent years. However, existing generative models mainly focus on synthesizing whole-organ or large-tissue structures, showing…

Image and Video Processing · Electrical Eng. & Systems 2025-12-19 Jiahao Xia , Yutao Hu , Yaolei Qi , Zhenliang Li , Wenqi Shao , Junjun He , Ying Fu , Longjiang Zhang , Guanyu Yang

Diffusion models face a fundamental trade-off between generation quality and computational efficiency. Latent Diffusion Models (LDMs) offer an efficient solution but suffer from potential information loss and non-end-to-end training. In…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Zhennan Chen , Junwei Zhu , Xu Chen , Jiangning Zhang , Xiaobin Hu , Hanzhen Zhao , Chengjie Wang , Jian Yang , Ying Tai

Anatomy shape modeling is a fundamental problem in medical data analysis. However, the geometric complexity and topological variability of anatomical structures pose significant challenges to accurate anatomical shape generation. In this…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Guoqing Zhang , Jingyun Yang , Siqi Chen , Anping Zhang , Yang Li

Due to the cross-domain distribution shift aroused from diverse medical imaging systems, many deep learning segmentation methods fail to perform well on unseen data, which limits their real-world applicability. Recent works have shown the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-06 Shangqi Gao , Hangqi Zhou , Yibo Gao , Xiahai Zhuang

Advances in latent diffusion models (LDMs) have revolutionized high-resolution image generation, but the design space of the autoencoder that is central to these systems remains underexplored. In this paper, we introduce LiteVAE, a new…

Machine Learning · Computer Science 2025-01-22 Seyedmorteza Sadat , Jakob Buhmann , Derek Bradley , Otmar Hilliges , Romann M. Weber