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Background: Large language models (LLMs) are rapidly being integrated into healthcare, promising to enhance various clinical tasks. However, concerns exist regarding their potential for bias, which could compromise patient care and…

Computation and Language · Computer Science 2025-04-07 Thanathip Suenghataiphorn , Narisara Tribuddharat , Pojsakorn Danpanichkul , Narathorn Kulthamrongsri

Importance: We introduce a novel Retrieval Augmented Generation (RAG)-Large Language Model (LLM) framework as a Clinical Decision Support Systems (CDSS) to support safe medication prescription. Objective: To evaluate the efficacy of…

Large language models (LLMs) hold promise in clinical decision support but face major challenges in safety evaluation and effectiveness validation. We developed the Clinical Safety-Effectiveness Dual-Track Benchmark (CSEDB), a…

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Large Language Models (LLMs) have demonstrated surprising performance across various natural language processing tasks. Recently, medical LLMs enhanced with domain-specific knowledge have exhibited excellent capabilities in medical…

Computation and Language · Computer Science 2024-09-24 Jinqiang Wang , Huansheng Ning , Yi Peng , Qikai Wei , Daniel Tesfai , Wenwei Mao , Tao Zhu , Runhe Huang

The rise of large language models (LLMs) has transformed healthcare by offering clinical guidance, yet their direct deployment to patients poses safety risks due to limited domain expertise. To mitigate this, we propose repositioning LLMs…

Computation and Language · Computer Science 2025-10-14 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Prayag Tiwari , Xiang Wan , Feng Jiang , Benyou Wang

Amidst escalating concerns about the detriments inflicted by AI systems, risk management assumes paramount importance, notably for high-risk applications as demanded by the European Union AI Act. Guidelines provided by ISO and NIST aim to…

Computers and Society · Computer Science 2024-06-19 sundaraparipurnan Narayanan , Sandeep Vishwakarma

Automated clinical text anonymization has the potential to unlock the widespread sharing of textual health data for secondary usage while assuring patient privacy and safety. Despite the proposal of many complex and theoretically successful…

Computation and Language · Computer Science 2024-06-05 David Pissarra , Isabel Curioso , João Alveira , Duarte Pereira , Bruno Ribeiro , Tomás Souper , Vasco Gomes , André V. Carreiro , Vitor Rolla

The use of Large Language Models (LLM) by providers of cybersecurity and digital infrastructures of all kinds is an ongoing development. It is suggested and on an experimental basis used to write the code for the systems, and potentially…

Computers and Society · Computer Science 2025-12-19 Kaspar Rosager Ludvigsen

Large-scale language models (LLMs) often offer clinical judgments based on incomplete information, increasing the risk of misdiagnosis. Existing studies have primarily evaluated confidence in single-turn, static settings, overlooking the…

Computation and Language · Computer Science 2026-01-23 Zhiyao Ren , Yibing Zhan , Siyuan Liang , Guozheng Ma , Baosheng Yu , Dacheng Tao

Large language models (LLMs) offer transformative potential for clinical decision support in spine surgery but pose significant risks through hallucinations, which are factually inconsistent or contextually misaligned outputs that may…

Machine Learning · Computer Science 2025-11-21 Dong Chen , Yanzhe Wei , Zonglin He , Guan-Ming Kuang , Canhua Ye , Meiru An , Huili Peng , Yong Hu , Huiren Tao , Kenneth MC Cheung

We introduce a multi-turn benchmark for evaluating personalised alignment in LLM-based AI assistants, focusing on their ability to handle user-provided safety-critical contexts. Our assessment of ten leading models across five scenarios…

Human-Computer Interaction · Computer Science 2025-01-31 Lize Alberts , Benjamin Ellis , Andrei Lupu , Jakob Foerster

Medical systematic reviews play a vital role in healthcare decision making and policy. However, their production is time-consuming, limiting the availability of high-quality and up-to-date evidence summaries. Recent advancements in large…

Computation and Language · Computer Science 2023-10-19 Hye Sun Yun , Iain J. Marshall , Thomas A. Trikalinos , Byron C. Wallace

Large language models (LLMs) are increasingly applied in biomedical domains, yet their reliability in drug-safety prediction remains underexplored. In this work, we investigate whether LLMs incorporate socio-demographic information into…

Computation and Language · Computer Science 2025-10-17 Siying Liu , Shisheng Zhang , Indu Bala

Evaluating medical AI systems using expert clinician panels is costly and slow, motivating the use of large language models (LLMs) as alternative adjudicators. Here, we evaluate an LLM jury composed of three frontier AI models scoring 3333…

In this paper, we explore the feasibility of leveraging large language models (LLMs) to automate or otherwise assist human raters with identifying harmful content including hate speech, harassment, violent extremism, and election…

Recent advancements in artificial intelligence (AI), especially large language models (LLMs), have significantly advanced healthcare applications and demonstrated potentials in intelligent medical treatment. However, there are conspicuous…

Computation and Language · Computer Science 2025-05-26 Qinkai Yu , Mingyu Jin , Dong Shu , Chong Zhang , Lizhou Fan , Wenyue Hua , Suiyuan Zhu , Yanda Meng , Zhenting Wang , Mengnan Du , Yongfeng Zhang

The evaluation of Large Language Models (LLMs) in healthcare has been dominated by physician-centric, English-language benchmarks, creating a dangerous illusion of competence that ignores the interprofessional nature of patient care. To…

Computation and Language · Computer Science 2025-06-30 Andrew Maranhão Ventura D'addario

Large language models (LLMs) represent significant breakthroughs in artificial intelligence and hold potential for applications within smart grids. However, as demonstrated in previous literature, AI technologies are susceptible to various…

Cryptography and Security · Computer Science 2025-04-22 Jiangnan Li , Yingyuan Yang , Jinyuan Sun