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Variational Quantum Algorithm (VQA) is a hybrid algorithm for noisy quantum devices. However, statistical fluctuations and physical noise degrade the solution quality, so it is difficult to maintain applicability for large-scale problems.…

Quantum Physics · Physics 2025-04-18 Hiromichi Matsuyama , Yu Yamashiro

Hybrid quantum mechanical-molecular mechanical (QM/MM) simulations are widely used in enzyme simulation. Over ten convergence studies of QM/MM methods have revealed over the past several years that key energetic and structural properties…

Chemical Physics · Physics 2017-01-11 Maria Karelina , Heather J. Kulik

Excitement about the promise of quantum computers is tempered by the reality that the hardware remains exceptionally fragile and error-prone, forming a bottleneck in the development of novel applications. In this manuscript, we describe and…

Simulations of chemical dynamics are a powerful means for understanding chemistry. However, classical computers struggle to simulate many chemical processes, especially non-adiabatic ones, where the Born-Oppenheimer approximation breaks…

The characterization of quantum dynamics is a fundamental and central task in quantum mechanics. This task is typically addressed by quantum process tomography (QPT). Here we present an alternative "direct characterization of quantum…

Quantum Physics · Physics 2007-05-23 M. Mohseni , D. A. Lidar

The performance and scalability of semiconductor quantum-dot (QD) qubits are limited by electrostatic drift and charge noise that shift operating points and destabilize qubit parameters. As systems expand to large one- and two-dimensional…

Background: Understanding electronic interactions in protein active sites is fundamental to drug discovery and enzyme engineering, but remains computationally challenging due to exponential scaling of quantum mechanical calculations.…

Quantitative Methods · Quantitative Biology 2026-01-05 Biraja Ghoshal

We propose digitized counterdiabatic quantum sampling (DCQS), a hybrid quantum-classical algorithm for efficient sampling from energy-based models, such as low-temperature Boltzmann distributions. The method utilizes counterdiabatic…

Programmable quantum simulators such as superconducting quantum processors and ultracold atomic lattices represent rapidly developing emergent technology that may one day qualitatively outperform existing classical computers. Yet, apart…

Strongly Correlated Electrons · Physics 2025-03-11 Jin Ming Koh , Tommy Tai , Ching Hua Lee

Quantum computing is expected to play an important role in solving the problem of huge computational costs in various applications by utilizing the collective properties of quantum states, including superposition, interference, and…

Quantum Physics · Physics 2025-03-04 Hocheol Lim , Hyeon-Nae Jeon , June-Koo Rhee , Byungdu Oh , Kyoung Tai No

One of the main challenges in building a quantum processor is to characterize the environmental noise. Noise characterization can be achieved by exploiting different techniques, such as randomization where several sequences of random…

Quantum Physics · Physics 2020-11-04 Elena Ferraro , Marco De Michielis

Quantum chemistry calculations of large, strongly correlated systems are typically limited by the computation cost that scales exponentially with the size of the system. Quantum algorithms, designed specifically for quantum computers, can…

Parallelism of tight-binding molecular dynamics simulations is presented by means of the order-N electronic structure theory with the Wannier states, recently developed (J. Phys. Soc. Jpn. 69,3773 (2000)). An application is tested for…

Materials Science · Physics 2009-11-10 Masaaki Geshi , Takeo Hoshi , Takeo Fujiwara

Effective methods for characterizing the noise in quantum computing devices are essential for programming and debugging circuit performance. Existing approaches vary in the information obtained as well as the amount of quantum and classical…

Quantum Physics · Physics 2022-01-10 Megan L. Dahlhauser , Travis S. Humble

This Thesis delves into the development and implementation of quantum algorithms using the digital-analog quantum computing (DAQC) paradigm. It provides a comparative analysis of the performance of DAQC versus traditional digital…

Quantum Physics · Physics 2024-01-22 Ana Martin

The computational cost of exact methods for quantum simulation using classical computers grows exponentially with system size. As a consequence, these techniques can only be applied to small systems. By contrast, we demonstrate that quantum…

Quantum Physics · Physics 2008-12-17 Ivan Kassal , Stephen P. Jordan , Peter J. Love , Masoud Mohseni , Alán Aspuru-Guzik

Reconstructing the state of a complex quantum system represents a pivotal task for all quantum information applications, both for characterization purposes and for verification of quantum protocols. Recent technological developments have…

The characterization of the dynamics of quantum systems is a task of both fundamental and practical importance. A general class of methods which have been developed in quantum information theory to accomplish this task is known as quantum…

Quantum Physics · Physics 2007-07-03 M. Mohseni , D. A. Lidar

Quantum computing has become increasingly practical in solving real-world problems due to advances in hardware and algorithms. In this paper, we aim to design and estimate quantum machine learning and hybrid quantum-classical models in a…

Quantum Physics · Physics 2025-07-14 Leyang Wang , Yilun Gong , Zongrui Pei

We present the Virtual Quantum Device (VQD) platform, a system based on the QuEST quantum emulator. Through the use of VQDs, non-expert users can emulate specific quantum computers with detailed error models, bespoke gate sets and…

Quantum Physics · Physics 2025-02-26 Cica Gustiani , Tyson Jones , Simon C. Benjamin