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Related papers: Probabilistic Modeling of Multi-rater Medical Imag…

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Segmentation of anatomical structures and pathologies is inherently ambiguous. For instance, structure borders may not be clearly visible or different experts may have different styles of annotating. The majority of current state-of-the-art…

Recent advances in promptable segmentation, such as the Segment Anything Model (SAM), have enabled flexible, high-quality mask generation across a wide range of visual domains. However, SAM and similar models remain fundamentally…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Tyler Ward , Abdullah Imran

Multi-rater medical image segmentation captures the inherent ambiguity of clinical interpretation, where diagnostic boundaries vary across experts and imaging devices. Existing approaches often reduce this diversity to consensus labels or…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Sanaz Karimijafarbigloo , Armin Khosravi , Alireza Kheyrkhah , Reza Azad , Mauricio Reyes , Dorit Merhof

Annotation ambiguity due to inherent data uncertainties such as blurred boundaries in medical scans and different observer expertise and preferences has become a major obstacle for training deep-learning based medical image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2024-03-21 Yicheng Wu , Xiangde Luo , Zhe Xu , Xiaoqing Guo , Lie Ju , Zongyuan Ge , Wenjun Liao , Jianfei Cai

Objective: Accurate probability estimates are essential for the safe deployment of medical image segmentation models in clinical decision-making. However, modern deep segmentation networks are often poorly calibrated, a problem exacerbated…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Meritxell Riera-Marín , Javier García López , Júlia Rodríguez-Comas , Miguel A. González Ballester , Adrian Galdran

Medical image segmentation is inherently uncertain. For a given image, there may be multiple plausible segmentation hypotheses, and physicians will often disagree on lesion and organ boundaries. To be suited to real-world application,…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 João Lourenço Silva , Arlindo L. Oliveira

Lesions or organ boundaries visible through medical imaging data are often ambiguous, thus resulting in significant variations in multi-reader delineations, i.e., the source of aleatoric uncertainty. In particular, quantifying the…

Computer Vision and Pattern Recognition · Computer Science 2022-01-19 Xiaofeng Liu , Fangxu Xing , Thibault Marin , Georges El Fakhri , Jonghye Woo

We address the selection and evaluation of uncertain segmentation methods in medical imaging and present two case studies: prostate segmentation, illustrating that for minimal annotator variation simple deterministic models can suffice, and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-24 Kilian Zepf , Jes Frellsen , Aasa Feragen

Medical image segmentation is a challenging task, particularly due to inter- and intra-observer variability, even between medical experts. In this paper, we propose a novel model, called Probabilistic Inter-Observer and iNtra-Observer…

Image and Video Processing · Electrical Eng. & Systems 2023-07-24 Arne Schmidt , Pablo Morales-Álvarez , Rafael Molina

Automated medical image segmentation suffers from high inter-observer variability, particularly in tasks such as lung nodule delineation, where experts often disagree. Existing approaches either collapse this variability into a consensus…

Automated medical image segmentation inherently involves a certain degree of uncertainty. One key factor contributing to this uncertainty is the ambiguity that can arise in determining the boundaries of a target region of interest,…

Image and Video Processing · Electrical Eng. & Systems 2023-08-28 Qingqiao Hu , Hao Wang , Jing Luo , Yunhao Luo , Zhiheng Zhangg , Jan S. Kirschke , Benedikt Wiestler , Bjoern Menze , Jianguo Zhang , Hongwei Bran Li

Medical image segmentation often involves inherent uncertainty due to variations in expert annotations. Capturing this uncertainty is an important goal and previous works have used various generative image models for the purpose of…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Jakob Lønborg Christensen , Morten Rieger Hannemose , Anders Bjorholm Dahl , Vedrana Andersen Dahl

Annotation variability remains a substantial challenge in medical image segmentation, stemming from ambiguous imaging boundaries and diverse clinical expertise. Traditional deep learning methods producing single deterministic segmentation…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Han Zhang , Xiangde Luo , Yong Chen , Kang Li

In the domain of medical imaging, many supervised learning based methods for segmentation face several challenges such as high variability in annotations from multiple experts, paucity of labelled data and class imbalanced datasets. These…

Computer Vision and Pattern Recognition · Computer Science 2025-05-15 Soumick Chatterjee , Franziska Gaidzik , Alessandro Sciarra , Hendrik Mattern , Gábor Janiga , Oliver Speck , Andreas Nürnberger , Sahani Pathiraja

Multi-rater annotations commonly occur when medical images are independently annotated by multiple experts (raters). In this paper, we tackle two challenges arisen in multi-rater annotations for medical image segmentation (called ambiguous…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Jinhong Wang , Yi Cheng , Jintai Chen , Hongxia Xu , Danny Chen , Jian Wu

Many real-world vision problems suffer from inherent ambiguities. In clinical applications for example, it might not be clear from a CT scan alone which particular region is cancer tissue. Therefore a group of graders typically produces a…

In image segmentation, there is often more than one plausible solution for a given input. In medical imaging, for example, experts will often disagree about the exact location of object boundaries. Estimating this inherent uncertainty and…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Miguel Monteiro , Loïc Le Folgoc , Daniel Coelho de Castro , Nick Pawlowski , Bernardo Marques , Konstantinos Kamnitsas , Mark van der Wilk , Ben Glocker

Medical image segmentation is a challenging task with inherent ambiguity and high uncertainty, attributed to factors such as unclear tumor boundaries and multiple plausible annotations. The accuracy and diversity of segmentation masks are…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Tao Chen , Chenhui Wang , Hongming Shan

A major challenge in the segmentation of medical images is the large inter- and intra-observer variability in annotations provided by multiple experts. To address this challenge, we propose a novel method for multi-expert prediction using…

Image and Video Processing · Electrical Eng. & Systems 2023-06-16 Tomer Amit , Shmuel Shichrur , Tal Shaharabany , Lior Wolf

Pre-trained segmentation models are a powerful and flexible tool for segmenting images. Recently, this trend has extended to medical imaging. Yet, often these methods only produce a single prediction for a given image, neglecting inherent…

Computer Vision and Pattern Recognition · Computer Science 2025-03-14 Benjamin Towle , Xin Chen , Ke Zhou
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