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Learning causal relationships between pairs of complex traits from observational studies is of great interest across various scientific domains. However, most existing methods assume the absence of unmeasured confounding and restrict causal…

Methodology · Statistics 2024-07-17 Wei Li , Rui Duan , Sai Li

The proximal causal inference framework enables the identification and estimation of causal effects in the presence of unmeasured confounding by leveraging two disjoint sets of observed strong proxies: negative control treatments and…

Methodology · Statistics 2025-12-16 Antonio Olivas-Martinez , Peter B. Gilbert , Andrea Rotnitzky

Causal decomposition has provided a powerful tool to analyze health disparity problems, by assessing the proportion of disparity caused by each mediator. However, most of these methods lack \emph{policy implications}, as they fail to…

Methodology · Statistics 2023-02-21 Xinwei Sun , Xiangyu Zheng , Jim Weinstein

The propensity score is a common tool for estimating the causal effect of a binary treatment in observational data. In this setting, matching, subclassification, imputation, or inverse probability weighting on the propensity score can…

Methodology · Statistics 2018-01-03 Michael J Lopez , Roee Gutman

Unobserved confounding is a fundamental obstacle to establishing valid causal conclusions from observational data. Two complementary types of approaches have been developed to address this obstacle: obtaining identification using fortuitous…

Methodology · Statistics 2023-06-27 Ilya Shpitser , Zach Wood-Doughty , Eric J. Tchetgen Tchetgen

Inferring causal structures from time series data is the central interest of many scientific inquiries. A major barrier to such inference is the problem of subsampling, i.e., the frequency of measurement is much lower than that of causal…

Machine Learning · Computer Science 2023-12-27 Mingzhou Liu , Xinwei Sun , Lingjing Hu , Yizhou Wang

Causal inference methods based on conditional independence construct Markov equivalent graphs, and cannot be applied to bivariate cases. The approaches based on independence of cause and mechanism state, on the contrary, that causal…

Machine Learning · Computer Science 2021-08-04 Nataliya Sokolovska , Pierre-Henri Wuillemin

Recovering causal structure in the presence of latent variables is an important but challenging task. While many methods have been proposed to handle it, most of them require strict and/or untestable assumptions on the causal structure. In…

Machine Learning · Computer Science 2025-10-28 Wei Chen , Linjun Peng , Zhiyi Huang , Haoyue Dai , Zhifeng Hao , Ruichu Cai , Kun Zhang

We consider linear structural equation models with explicitly modelled latent variables. In such models, observed and latent variables solve linear equations including stochastic noise terms. The goal of our work is to identify the direct…

Methodology · Statistics 2026-05-28 Tom Hochsprung , Nils Sturma , Jakob Runge , Mathias Drton , Andreas Gerhardus

Assessing causal effects in the presence of unobserved confounding is a challenging problem. Existing studies leveraged proxy variables or multiple treatments to adjust for the confounding bias. In particular, the latter approach attributes…

Methodology · Statistics 2023-10-17 Yong Wu , Mingzhou Liu , Jing Yan , Yanwei Fu , Shouyan Wang , Yizhou Wang , Xinwei Sun

Causal inference often hinges on strong assumptions - such as no unmeasured confounding or perfect compliance - that are rarely satisfied in practice. Partial identification offers a principled alternative: instead of relying on…

Machine Learning · Computer Science 2025-08-20 Tobias Maringgele

This paper concerns the probabilistic evaluation of the effects of actions in the presence of unmeasured variables. We show that the identification of causal effect between a singleton variable X and a set of variables Y can be accomplished…

Artificial Intelligence · Computer Science 2013-02-21 David Galles , Judea Pearl

Causal discovery from observational data is a challenging task that can only be solved up to a set of equivalent solutions, called an equivalence class. Such classes, which are often large in size, encode uncertainties about the orientation…

Machine Learning · Computer Science 2022-03-01 Philippe Brouillard , Perouz Taslakian , Alexandre Lacoste , Sebastien Lachapelle , Alexandre Drouin

We address the setting of Proxy Causal Learning (PCL), which has the goal of estimating causal effects from observed data in the presence of hidden confounding. Proxy methods accomplish this task using two proxy variables related to the…

Machine Learning · Computer Science 2026-03-27 Bariscan Bozkurt , Ben Deaner , Dimitri Meunier , Liyuan Xu , Arthur Gretton

Proximal causal inference was recently proposed as a framework to identify causal effects from observational data in the presence of hidden confounders for which proxies are available. In this paper, we extend the proximal causal inference…

Statistics Theory · Mathematics 2023-01-27 AmirEmad Ghassami , Alan Yang , Ilya Shpitser , Eric Tchetgen Tchetgen

Causal decomposition analyses can help build the evidence base for interventions that address health disparities (inequities). They ask how disparities in outcomes may change under hypothetical intervention. Through study design and…

Methodology · Statistics 2020-09-17 John W. Jackson

We consider the problem of indirect comparison, where a treatment arm of interest is absent by design in one randomized controlled trial but available in the other. The former is the target trial, and the latter is the source trial. The…

Methodology · Statistics 2025-06-06 Zehao Su , Helene C. W. Rytgaard , Henrik Ravn , Frank Eriksson

One of the most fundamental problems in causal inference is the estimation of a causal effect when variables are confounded. This is difficult in an observational study, because one has no direct evidence that all confounders have been…

Machine Learning · Statistics 2014-11-03 Ricardo Silva , Robin Evans

Causal discovery algorithms estimate causal graphs from observational data. This can provide a valuable complement to analyses focussing on the causal relation between individual treatment-outcome pairs. Constraint-based causal discovery…

Methodology · Statistics 2021-08-31 Janine Witte , Ronja Foraita , Vanessa Didelez

Unobserved confounding is one of the greatest challenges for causal discovery. The case in which unobserved variables have a widespread effect on many of the observed ones is particularly difficult because most pairs of variables are…

Machine Learning · Statistics 2021-05-26 Alexis Bellot , Mihaela van der Schaar