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The report describes the discussions from the Workshop on Mathematical Opportunities in Digital Twins (MATH-DT) from December 11-13, 2023, George Mason University. It illustrates that foundational Mathematical advances are required for…

Optimization and Control · Mathematics 2024-03-25 Harbir Antil

Digital Twin technology is an emerging concept that has become the centre of attention for industry and, in more recent years, academia. The advancements in industry 4.0 concepts have facilitated its growth, particularly in the…

Computers and Society · Computer Science 2020-06-19 Aidan Fuller , Zhong Fan , Charles Day , Chris Barlow

Digital Twin (DT) technology is far from being comprehensive and mature, resulting in their piecemeal implementation in practice where some functions are automated by DTs, and others are still performed by humans. This piecemeal…

Human-Computer Interaction · Computer Science 2023-01-10 Ashwin Agrawal , Robert Thiel , Pooja Jain , Vishal Singh , Martin Fischer

The idea of a systematic digital representation of the entire known human pathophysiology, which we could call the Virtual Human Twin, has been around for decades. To date, most research groups focused instead on developing highly…

Medical Physics · Physics 2023-08-15 Marco Viceconti , Maarten De Vos , Sabato Mellone , Liesbet Geris

Digital twins are sophisticated software systems for the representation, monitoring, and control of cyber-physical systems, including automotive, avionics, smart manufacturing, and many more. Existing definitions and reference models of…

Software Engineering · Computer Science 2025-07-08 Jerome Pfeiffer , Jingxi Zhang , Benoit Combemale , Judith Michael , Bernhard Rumpe , Manuel Wimmer , Andreas Wortmann

Digital twin technology has is anticipated to transform healthcare, enabling personalized medicines and support, earlier diagnoses, simulated treatment outcomes, and optimized surgical plans. Digital twins are readily gaining traction in…

Machine Learning · Computer Science 2023-07-12 Logan Nye

With the increasing complexity of industrial systems, there is a pressing need for predictive maintenance to avoid costly downtime and disastrous outcomes that could be life-threatening in certain domains. With the growing popularity of the…

Artificial Intelligence · Computer Science 2025-09-30 Leila Ismail , Abdelmoneim Abdelmoti , Arkaprabha Basu , Aymen Dia Eddine Berini , Mohammad Naouss

The concept of a digital twin has exploded in popularity over the past decade, yet confusion around its plurality of definitions, its novelty as a new technology, and its practical applicability still exists, all despite numerous reviews,…

Machine Learning · Computer Science 2022-06-27 Brian Kunzer , Mario Berges , Artur Dubrawski

This article presents the general framework of theranostic digital twins (TDTs) in computational nuclear medicine, designed to support clinical decision-making and improve cancer patient prognosis through personalized radiopharmaceutical…

Other Quantitative Biology · Quantitative Biology 2025-11-07 Marc Ryhiner , Yangmeihui Song , Babak Saboury , Gerhard Glatting , Arman Rahmim , Kuangyu Shi

Digital twins (DTs) enable powerful predictive analytics, but persistent discrepancies between simulations and real systems--known as the reality gap--undermine their reliability. Coined in robotics, the term now applies to DTs, where…

Machine Learning · Computer Science 2026-01-29 Sizhe Ma , Katherine A. Flanigan , Mario Bergés

Digital twins (DT) have received significant attention due to their numerous benefits, such as real-time data analytics and cost reduction in production. DT serves as a fundamental component of many applications, encompassing smart…

Networking and Internet Architecture · Computer Science 2025-05-08 Chen Chen , Zihan Jia , Ze Wang , Lin Cui , Fung Po Tso

Datacenters are the backbone of our digital society, but raise numerous operational challenges. We envision digital twins becoming primary instruments in datacenter operations, continuously and autonomously helping with major operational…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-14 Radu Nicolae , Jules van der Toorn , Stavriana Kraniti , Houcen Liu , Alexandru Iosup

Purpose: This systematic literature review (SLR) characterizes the current state of the art on digital twinning (DT) technology in tourism-related applications. We aim to evaluate the types of DTs described in the literature, identifying…

Computers and Society · Computer Science 2025-02-04 Duarte Sampaio de Almeida , Fernando Brito e Abreu , Inês Boavida-Portugal

Digital twins (DTs), virtual simulated replicas of physical scenes, are transforming various industries. However, their potential in radio frequency (RF) sensing applications has been limited by the unidirectional nature of conventional RF…

Signal Processing · Electrical Eng. & Systems 2025-08-21 Xingyu Chen , Jianrong Ding , Kai Zheng , Xinmin Fang , Xinyu Zhang , Chris Xiaoxuan Lu , Zhengxiong Li

Digital twins have emerged as a powerful technology for modeling and simulating complex systems across various domains (Fuller et al., 2020; Tao et al., 2019). As virtual representations of physical assets, processes, or systems, digital…

Software Engineering · Computer Science 2025-07-08 Gabriella Waters

A patient's digital twin is a computational model that describes the evolution of their health over time. Digital twins have the potential to revolutionize medicine by enabling individual-level computer simulations of human health, which…

Recent technological advances have expanded the availability of high-throughput biological datasets, enabling the reliable design of digital twins of biomedical systems or patients. Such computational tools represent key reaction networks…

Quantitative Methods · Quantitative Biology 2025-09-03 Clémence Métayer , Annabelle Ballesta , Julien Martinelli

The concept of a digital twin (DT) plays a pivotal role in the ongoing digital transformation and has achieved significant strides for various wireless applications in recent years. In particular, the field of autonomous vehicles is a…

Networking and Internet Architecture · Computer Science 2024-01-18 Kui Wang , Tao Yu , Zongdian Li , Kei Sakaguchi , Omar Hashash , Walid Saad

Digital twins are virtual replicas of physical entities and are poised to transform personalized medicine through the real-time simulation and prediction of human physiology. Translating this paradigm from engineering to biomedicine…

Recently, the concept of digital twins (DTs) has received significant attention within the realm of 5G/6G. This demonstration shows an innovative DT design and implementation framework tailored toward integration within the 5G…

Networking and Internet Architecture · Computer Science 2023-08-31 Peizheng Li , Adnan Aijaz , Tim Farnham , Sajida Gufran , Sita Chintalapati
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