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Illuminated by the Pulse Width Modulation (PWM) technology in classical control engineering, we propose the PWM approximation which transforms continuous and bang-bang control into each other. This method works by squeezing the…
Electro-optical modulators are essential components in optical communication systems. They encode an electrical waveform onto an optical carrier. However, their performance is often limited by inherent electro-optic processes and…
We report a simple method to suppress the light shift in optical pumping systems. This method uses only frequency modulation of a radio frequency or microwave source, which is used to excite an atomic resonance, to simultaneously lock the…
A transducer of single photons between microwave and optical frequencies can be used to realize quantum communication over optical fiber links between distant superconducting quantum computers. A promising scalable approach to constructing…
The control of gene expression involves complex mechanisms that show large variation in design. For example, genes can be turned on either by the binding of an activator (positive control) or the unbinding of a repressor (negative control).…
In this paper, we consider the problem of controlling a dynamical system such that its trajectories satisfy a temporal logic property in a given amount of time. We focus on multi-affine systems and specifications given as syntactically…
Topology optimization has emerged as a powerful and increasingly relevant strategy for enhancing the flexibility and efficiency of power system operations. However, solving these problems is computationally demanding due to their…
We consider the problem of regulating by means of external control inputs the ratio of two cell populations. Specifically, we assume that these two cellular populations are composed of cells belonging to the same strain which embeds some…
In many applications, and in systems/synthetic biology, in particular, it is desirable to compute control policies that force the trajectory of a bistable system from one equilibrium (the initial point) to another equilibrium (the target…
Electrically tunable optical devices present diverse functionalities for manipulating electromagnetic waves by leveraging elements capable of reversibly switching between different optical states. This adaptability in adjusting their…
We investigate the problem of using a learning-based strategy to stabilize a synthetic toggle switch via an external control approach. To overcome the data efficiency problem that would render the algorithm unfeasible for practical use in…
In order to survive, reproduce and (in multicellular organisms) differentiate, cells must control the concentrations of the myriad different proteins that are encoded in the genome. The precision of this control is limited by the inevitable…
To enable multiple functions of plasmonic nanocircuits, it is of key importance to control the propagation properties and the modal distribution of the guided optical modes such that their impedance matches to that of nearby quantum systems…
In the simplest view of transcriptional regulation, the expression of a gene is turned on or off by changes in the concentration of a transcription factor (TF). We use recent data on noise levels in gene expression to show that it should be…
Cellular responses to death-promoting stimuli typically proceed through a differentiated multistage process, involving a lag phase, extensive death, and potential adaptation. Deregulation of this chain of events is at the root of many…
Since the advent of optogenetics, technology development has focused on new methods to optically interact with single nervous cells. This gave rise to the field of photonic neural interfaces, intended as the set of technologies that can…
This paper gives an overview of the use of control systems engineering in synthetic biology, motivated by applications such as cell therapy and cell fate reprogramming for regenerative medicine. A ubiquitous problem in these and other…
This paper explores the voltage regulation challenges in boost converter systems, which are critical components in power electronics due to their ability to step up voltage levels efficiently. The proposed control algorithm ensures…
We theoretically propose and numerically validate an all-optical scheme to generate optical pulse trains with varying peak-powers and durations. A shaping of the spectral phase thanks to discrete $\pi/2$ phase shifts enables an efficient…
Optical focusing through/inside scattering media, like multimode fiber and biological tissues, has significant impact in biomedicine yet considered challenging due to strong scattering nature of light. Previously, promising progress has…