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The convergence of statistical learning and molecular physics is transforming our approach to modeling biomolecular systems. Physics-informed machine learning (PIML) offers a systematic framework that integrates data-driven inference with…

Biomolecules · Quantitative Biology 2025-11-11 Aaryesh Deshpande

We propose physics-informed holomorphic neural networks (PIHNNs) as a method to solve boundary value problems where the solution can be represented via holomorphic functions. Specifically, we consider the case of plane linear elasticity…

Computational Engineering, Finance, and Science · Computer Science 2024-09-30 Matteo Calafà , Emil Hovad , Allan P. Engsig-Karup , Tito Andriollo

There has been rapid progress recently on the application of deep networks to the solution of partial differential equations, collectively labelled as Physics Informed Neural Networks (PINNs). In this paper, we develop Physics Informed…

Machine Learning · Computer Science 2019-07-09 Vikas Dwivedi , Balaji Srinivasan

Deep learning is a powerful tool for solving data driven differential problems and has come out to have successful applications in solving direct and inverse problems described by PDEs, even in presence of integral terms. In this paper, we…

Numerical Analysis · Mathematics 2023-12-19 Fabio Vito Difonzo , Luciano Lopez , Sabrina Francesca Pellegrino

Inverse problems arise across scientific and engineering domains, where the goal is to infer hidden parameters or physical fields from indirect and noisy observations. Classical approaches, such as variational regularization and Bayesian…

Machine Learning · Statistics 2025-12-03 Ali Mohammad-Djafari , Ning Chu , Li Wang

Solving inverse problems in dynamical systems governed by high-dimensional coupled ordinary differential equations (ODEs) is a ubiquitous challenge in scientific machine learning. In many real-world applications, researchers seek to uncover…

Machine Learning · Computer Science 2026-05-06 Zhao Wei , Kenneth Hor Cheng Koh , Sheng Yuan Chin , James Chun Yip Chan , Chin Chun Ooi , Yew-Soon Ong

Systems biology and systems neurophysiology in particular have recently emerged as powerful tools for a number of key applications in the biomedical sciences. Nevertheless, such models are often based on complex combinations of multiscale…

Neural and Evolutionary Computing · Computer Science 2022-09-27 Matteo Ferrante , Andera Duggento , Nicola Toschi

Physics-informed machine learning (PIML) has emerged as a promising alternative to conventional numerical methods for solving partial differential equations (PDEs). PIML models are increasingly built via deep neural networks (NNs) whose…

Machine Learning · Computer Science 2024-09-30 Carlos Mora , Amin Yousefpour , Shirin Hosseinmardi , Ramin Bostanabad

The inverse Stefan problem, as a typical phase-change problem with moving boundaries, finds extensive applications in science and engineering. Recent years have seen the applications of physics-informed neural networks (PINNs) to solving…

Machine Learning · Computer Science 2025-10-27 Pei-Zhi Zhuang , Ming-Yue Yang , Fei Ren , Hong-Ya Yue , He Yang

In recent years, Scientific Machine Learning (SciML) methods for solving partial differential equations (PDEs) have gained increasing popularity. Within such a paradigm, Physics-Informed Neural Networks (PINNs) are novel deep learning…

Numerical Analysis · Mathematics 2024-04-25 Pasquale Ambrosio , Salvatore Cuomo , Mariapia De Rosa

Deep learning has been highly successful in some applications. Nevertheless, its use for solving partial differential equations (PDEs) has only been of recent interest with current state-of-the-art machine learning libraries, e.g.,…

Machine Learning · Computer Science 2024-10-22 Hamid El Bahja , Jan Christian Hauffen , Peter Jung , Bubacarr Bah , Issa Karambal

In this paper, the physics-informed neural networks (PINN) is applied to high-dimensional system to solve the (N+1)-dimensional initial boundary value problem with 2N+1 hyperplane boundaries. This method is used to solve the most classic…

Exactly Solvable and Integrable Systems · Physics 2022-01-26 Zhengwu Miao , Yong Chen

In this paper, numerical methods using Physics-Informed Neural Networks (PINNs) are presented with the aim to solve higher-order ordinary differential equations (ODEs). Indeed, this deep-learning technique is successfully applied for…

Computational Physics · Physics 2023-07-17 Hubert Baty

Motivated by recent research on Physics-Informed Neural Networks (PINNs), we make the first attempt to introduce the PINNs for numerical simulation of the elliptic Partial Differential Equations (PDEs) on 3D manifolds. PINNs are one of the…

Numerical Analysis · Mathematics 2021-03-05 Zhuochao Tang , Zhuojia Fu

Classical Physics-informed neural networks (PINNs) approximate solutions to PDEs with the help of deep neural networks trained to satisfy the differential operator and the relevant boundary conditions. We revisit this idea in the quantum…

Quantum Physics · Physics 2023-12-27 Josh Dees , Antoine Jacquier , Sylvain Laizet

Flexoelectricity, the coupling between strain gradients and electric polarization, poses significant computational challenges due to its governing fourth-order partial differential equations that require C1-continuous solutions. To address…

Computational Physics · Physics 2025-06-30 Hyeonbin Moon , Donggeun Park , Jinwook Yeo , Seunghwa Ryu

As an emerging technology in deep learning, physics-informed neural networks (PINNs) have been widely used to solve various partial differential equations (PDEs) in engineering. However, PDEs based on practical considerations contain…

Machine Learning · Computer Science 2021-11-11 Yuhao Huang

Physics-informed neural network (PINN) is a data-driven solver for partial and ordinary differential equations(ODEs/PDEs). It provides a unified framework to address both forward and inverse problems. However, the complexity of the…

Machine Learning · Computer Science 2024-01-17 Abdul Hannan Mustajab , Hao Lyu , Zarghaam Rizvi , Frank Wuttke

In this paper, we develop a deep learning approach for the accurate solution of challenging problems of near-field microscopy that leverages the powerful framework of physics-informed neural networks (PINNs) for the inversion of the complex…

Optics · Physics 2024-06-12 Yuyao Chen , Luca Dal Negro

Despite the great promise of the physics-informed neural networks (PINNs) in solving forward and inverse problems, several technical challenges are present as roadblocks for more complex and realistic applications. First, most existing…

Computational Engineering, Finance, and Science · Computer Science 2022-01-26 Han Gao , Matthew J. Zahr , Jian-Xun Wang