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Mid-infrared spectroscopy offers powerful label-free molecular analysis capabilities but faces significant challenges when analyzing complex biological samples. Here, we present a transformative surface-enhanced infrared absorption…

Waveguide-integrated plasmonics is a growing field with many innovative concepts and demonstrated devices in the visible and near-infrared. Here, we extend this body of work to the mid-infrared for the application of surface-enhanced…

Optics · Physics 2018-12-05 Daniel A. Mohr , Daehan Yoo , Che Chen , Mo Li , Sang-Hyun Oh

Surface-enhanced spectroscopy techniques are the method-of-choice to characterize adsorbed intermediates occurring during electrochemical reactions, which are crucial in realizing a green sustainable future. Characterizing species with low…

Mesoscale and Nanoscale Physics · Physics 2023-07-21 Malo Duportal , Luca M. Berger , Stefan A. Maier , Andreas Tittl , Katharina Krischer

Label-free and nondestructive mid-infrared vibrational hyperspectral imaging is emerging as an important ex-vivo tissue analysis tool, providing spatially resolved biochemical information critical to understanding physiological and…

The absorption and emission spectrum arising from the vibrational motion of a molecule is mostly in the infrared region. These fingerprint absorptions of polar bonds enable us to acquire bond-specific chemical information from specimens.…

Optics · Physics 2024-11-15 Govind Dayal , Dheeraj Pratap

Electrocatalysis plays a crucial role in realizing the transition towards green energy, driving research directions from hydrogen generation to carbon dioxide reduction. Understanding electrochemical reactions is crucial to improve their…

Surface Enhanced Infrared Absorption (SEIRA) is an experimental method where trace amount of a compound can be detected with high sensibility. This high detection sensibility is the result of the interaction of the molecules with a…

Surface-enhanced infrared absorption (SEIRA) spectroscopy exploits the field enhancement near nanophotonic structures for highly sensitive characterization of (bio)molecules. The vibrational signature observed in SEIRA spectra is typically…

We present a multiscale quantum mechanics/classical (QM/MM) approach for modeling surface-enhanced infrared absorption (SEIRA) spectra of molecules adsorbed on plasmonic nanostructures. The molecular subsystem is described at the density…

Chemical Physics · Physics 2025-11-05 Sveva Sodomaco , Piero Lafiosca , Tommaso Giovannini , Chiara Cappelli

Sensing with undetected photons has become a vibrant, application-driven research domain with a special focus on the mid-infrared (mid-IR) wavelength region. Since the mid-IR contains spectral bands with highly specific and strong molecular…

Broadband mid-infrared (mid-IR) spectroscopy applications could greatly benefit from today's well-developed, highly scalable silicon photonics technology; however, this platform lacks broadband transparency due to its reliance on absorptive…

The paper presents main aspects of the Dipole-Quadrupole theory of Surface Enhanced Infrared Absorption (SEIRA). It is pointed out the possibility of appearance of the lines, caused by totally symmetric vibrations transforming after the…

Optics · Physics 2015-06-04 A. M. Polubotko

Optical metasurfaces can manipulate electromagnetic waves in unprecedented ways at ultra-thin engineered interfaces. Specifically, in the mid-infrared (mid-IR) region, metasurfaces have enabled numerous biochemical sensing, spectroscopy,…

Numerous molecules exhibit unique absorption bands in the fingerprint infrared (IR) region, allowing chemical identification and detection. This makes IR spectroscopy an essential tool in biomedical diagnostics, sensing, and material…

Optics · Physics 2022-02-04 Anna V. Paterova , Zi S. D. Toa , Hongzhi Yang , Leonid A. Krivitsky

Shortwave-infrared(SWIR) spectral information, ranging from 1 {\mu}m to 2.5{\mu}m, overcomes the limitations of traditional color cameras in acquiring scene information. However, conventional SWIR hyperspectral imaging systems face…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Linqiang Li , Jinglei Hao , Yongqiang Zhao , Pan Liu , Haofang Yan , Ziqin Zhang , Seong G. Kong

Detecting trace molecules remains a significant challenge. Surface-enhanced infrared absorption (SEIRA) based on plasmonic nanostructures, particularly graphene, has emerged as a promising approach to enhance sensing sensitivity. While…

Infrared (IR) spectroscopy has emerged as a pivotal tool in biomedical diagnostics, offering label-free spectral biomarkers for the detection of numerous diseases, particularly in the fingerprint region. However, the lack of rapid and…

Optics · Physics 2026-01-12 Xiangyu Zhao , Yuqing Liu , Jingzhu Shao , Longsheng Fang , Chongzhao Wu

Mid-infrared (MIR) spectroscopy is widely recognized as a powerful, non-distractive method for chemical analysis. However, its utility is constrained by a micrometer-scale spatial resolution imposed by the long-wavelength MIR diffraction…

We investigate local heat generation by molecules at the apex of polymer-embedded vertical antennas excited at resonant mid-infrared wavelengths, exploiting the surface enhanced infrared absorption (SEIRA) effect. The embedding of vertical…

Owing to its capacity for unique (bio)-chemical specificity, microscopy withmid-IR illumination holds tremendous promise for a wide range of biomedical and industrial applications. The primary limitation, however, remains detection; with…

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