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Drug synergy prediction (DSP) aims to identify efficacious drug combinations under various cellular contexts with different targets. However, the continual emergence of novel compounds results in variations in molecular scaffolds and sizes,…

Machine Learning · Computer Science 2026-05-29 Xin Wang , Linxin Xiao , Yang Yao , Wenwu Zhu

We study how much a linear program (LP) can be compressed when solved repeatedly, given prior knowledge about its objective function. Existing data-driven projection methods learn low-dimensional surrogate LPs with approximate…

Optimization and Control · Mathematics 2026-05-26 Yuhan Ye , Omar Bennouna

A linked system of symmetric designs (LSSD) is a $w$-partite graph ($w\geq 2$) where the incidence between any two parts corresponds to a symmetric design and the designs arising from three parts are related. The original construction for…

Combinatorics · Mathematics 2017-12-11 Brian Kodalen

Mixed integer nonlinear programming (MINLP) problems are encountered in modeling a physical/industrial process consisting both nonlinearity and discrete selective parameters. There are variety of algorithms for solving MINLP problems most…

Optimization and Control · Mathematics 2024-05-17 Negin Bagherpour , Mahdi Sharifzadeh

A $\lambda$-cover of a string $S$ is a set of strings $\{C_i\}_1^\lambda$ such that every index in $S$ is contained in an occurrence of at least one string $C_i$. The existence of a $1$-cover defines a well-known class of quasi-periodic…

Data Structures and Algorithms · Computer Science 2024-05-21 Itai Boneh , Shay Golan , Arseny Shur

We have formulated the problem of generating periodic dense paritcle packings as an optimization problem called the Adaptive Shrinking Cell (ASC) formulation [S. Torquato and Y. Jiao, Phys. Rev. E {\bf 80}, 041104 (2009)]. Because the…

Statistical Mechanics · Physics 2010-12-15 Sal Torquato , Yang Jiao

Suppose we want to seek the longest common subsequences (LCSs) of two strings as informative patterns that explain the relationship between the strings. The dynamic programming algorithm gives us a table from which all LCSs can be extracted…

Data Structures and Algorithms · Computer Science 2025-05-23 Yoshifumi Sakai

Two important similarity measures between sequences are the longest common subsequence (LCS) and the dynamic time warping distance (DTWD). The computations of these measures for two given sequences are central tasks in a variety of…

Computational Complexity · Computer Science 2015-02-02 Amir Abboud , Arturs Backurs , Virginia Vassilevska Williams

We present an algorithm that, given an index $t$, produces the $t$-th (lexicographically ordered) answer of an MSO query over a string. The algorithm requires linear-time preprocessing, and builds a data structure that answers each of these…

Data Structures and Algorithms · Computer Science 2026-03-16 Martín Muñoz

A sparse linear programming (SLP) problem is a linear programming problem equipped with a sparsity (or cardinality) constraint, which is nonconvex and discontinuous theoretically and generally NP-hard computationally due to the…

Optimization and Control · Mathematics 2018-06-05 Chen Zhao , Ziyan Luo , Weiyue Li , Houduo Qi , Naihua Xiu

Merging the two cultures of deep and statistical learning provides insights into structured high-dimensional data. Traditional statistical modeling is still a dominant strategy for structured tabular data. Deep learning can be viewed…

Methodology · Statistics 2021-10-25 Anindya Bhadra , Jyotishka Datta , Nick Polson , Vadim Sokolov , Jianeng Xu

We revisit the classic problem of simplex range searching and related problems in computational geometry. We present a collection of new results which improve previous bounds by multiple logarithmic factors that were caused by the use of…

Computational Geometry · Computer Science 2022-10-24 Timothy M. Chan , Da Wei Zheng

LP-type problems such as the Minimum Enclosing Ball (MEB), Linear Support Vector Machine (SVM), Linear Programming (LP), and Semidefinite Programming (SDP) are fundamental combinatorial optimization problems, with many important…

Data Structures and Algorithms · Computer Science 2025-07-17 N. Efe Çekirge , William Gay , David P. Woodruff

We introduce and study level-planar straight-line drawings with a fixed number $\lambda$ of slopes. For proper level graphs, we give an $O(n \log^2 n / \log \log n)$-time algorithm that either finds such a drawing or determines that no such…

Data Structures and Algorithms · Computer Science 2019-08-02 Guido Brückner , Nadine Davina Krisam , Tamara Mchedlidze

In this paper we investigate the problem of building a static data structure that represents a string s using space close to its compressed size, and allows fast access to individual characters of s. This type of structures was investigated…

Computational Complexity · Computer Science 2012-05-04 Shiteng Chen , Elad Verbin , Wei Yu

The longest square subsequence (LSS) problem consists of computing a longest subsequence of a given string $S$ that is a square, i.e., a longest subsequence of form $XX$ appearing in $S$. It is known that an LSS of a string $S$ of length…

Data Structures and Algorithms · Computer Science 2020-07-30 Takafumi Inoue , Shunsuke Inenaga , Hideo Bannai

Geometric data structures have been extensively studied in the regime where the dimension is much smaller than the number of input points. But in many scenarios in Machine Learning, the dimension can be much higher than the number of points…

Data Structures and Algorithms · Computer Science 2025-04-07 Martin G. Herold , Danupon Nanongkai , Joachim Spoerhase , Nithin Varma , Zihang Wu

The palindromic tree (a.k.a. eertree) for a string $S$ of length $n$ is a tree-like data structure that represents the set of all distinct palindromic substrings of $S$, using $O(n)$ space [Rubinchik and Shur, 2018]. It is known that, when…

Data Structures and Algorithms · Computer Science 2020-11-12 Takuya Mieno , Kiichi Watanabe , Yuto Nakashima , Shunsuke Inenaga , Hideo Bannai , Masayuki Takeda

In this paper, a fully compressed pattern matching problem is studied. The compression is represented by straight-line programs (SLPs), i.e. a context-free grammars generating exactly one string; the term fully means that both the pattern…

Data Structures and Algorithms · Computer Science 2013-06-26 Artur Jeż

Semidefinite programs (SDP) are one of the most versatile frameworks in numerical optimization, serving as generalizations of many conic programs and as relaxations of NP-hard combinatorial problems. Their main drawback is their…

Optimization and Control · Mathematics 2022-02-28 Biel Roig-Solvas , Mario Sznaier