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Pathology has played a crucial role in the diagnosis and evaluation of patient tissue samples obtained from surgeries and biopsies for many years. The advent of Whole Slide Scanners and the development of deep learning technologies have…

Computer Vision and Pattern Recognition · Computer Science 2024-08-07 Mieko Ochi , Daisuke Komura , Shumpei Ishikawa

Pain management and severity detection are crucial for effective treatment, yet traditional self-reporting methods are subjective and may be unsuitable for non-verbal individuals (people with limited speaking skills). To address this…

Computer Vision and Pattern Recognition · Computer Science 2025-02-27 Aafaf Ridouan , Amine Bohi , Youssef Mourchid

Deep learning models show promise in digital pathology, but their opaque decision-making processes limit trust and clinical adoption. To address this challenge, we present HIPPO, an explainable AI method for analyzing weakly-supervised…

Tissues and Organs · Quantitative Biology 2025-12-10 Jakub R. Kaczmarzyk , Chanwoo Kim , Soham Gadgil , Deepika Savant , Zhen Zhao , Joel H. Saltz , Su-In Lee , Peter K. Koo

Lesion segmentation is the first step in most automatic melanoma recognition systems. Deficiencies and difficulties in dermoscopic images such as color inconstancy, hair occlusion, dark corners and color charts make lesion segmentation an…

Computer Vision and Pattern Recognition · Computer Science 2018-06-08 Mostafa Jahanifar , Neda Zamani Tajeddin , Babak Mohammadzadeh Asl , Ali Gooya

Deep learning based automated pathological diagnosis has markedly improved diagnostic efficiency and reduced variability between observers, yet its clinical adoption remains limited by opaque model decisions and a lack of traceable…

In the field of Explainable Artificial Intelligence (XAI), argumentative XAI approaches have been proposed to represent the internal reasoning process of deep neural networks in a more transparent way by interpreting hidden nodes as…

Artificial Intelligence · Computer Science 2025-03-06 Ungsik Kim

Accurate pain assessment is crucial in healthcare for effective diagnosis and treatment; however, traditional methods relying on self-reporting are inadequate for populations unable to communicate their pain. Cutting-edge AI is promising…

Computer Vision and Pattern Recognition · Computer Science 2024-10-16 Minh-Duc Nguyen , Hyung-Jeong Yang , Soo-Hyung Kim , Ji-Eun Shin , Seung-Won Kim

Masked Image Modeling (MIM) achieves outstanding success in self-supervised representation learning. Unfortunately, MIM models typically have huge computational burden and slow learning process, which is an inevitable obstacle for their…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Haoqing Wang , Yehui Tang , Yunhe Wang , Jianyuan Guo , Zhi-Hong Deng , Kai Han

The elasticity of soft tissues has been widely considered as a characteristic property to differentiate between healthy and vicious tissues and, therefore, motivated several elasticity imaging modalities, such as Ultrasound Elastography,…

Image and Video Processing · Electrical Eng. & Systems 2022-05-30 Weiguo Cao , Marc J. Pomeroy , Zhengrong Liang , Yongfeng Gao , Yongyi Shi , Jiaxing Tan , Fangfang Han , Jing Wang , Jianhua Ma , Hongbin Lu , Almas F. Abbasi , Perry J. Pickhardt

The evaluation and treatment of acute cerebral ischemia requires a technique that can determine the total area of tissue at risk for infarction using diagnostic magnetic resonance imaging (MRI) sequences. Typical MRI data sets consist of…

Computer Vision and Pattern Recognition · Computer Science 2016-06-14 Vishwa S. Parekh , Jeremy R. Jacobs , Michael A. Jacobs

Musculoskeletal disorders represent a leading cause of global disability, creating an urgent demand for precise interpretation of medical imaging. Current artificial intelligence (AI) approaches in orthopedics predominantly rely on…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Kang Yu , Dingyu Wang , Zimu Yuan , Nan Zhou , Jiajun Liu , Jiaxin Liu , Shanggui Liu , Yaoyan Zheng , Huishu Yuan , Di Huang , Dong Jiang

Recovering the T2 distribution from multi-echo T2 magnetic resonance (MR) signals is challenging but has high potential as it provides biomarkers characterizing the tissue micro-structure, such as the myelin water fraction (MWF). In this…

Accurate longitudinal analysis of brain MRI is often hindered by evolving lesions, which bias automated neuroimaging pipelines. While deep generative models have shown promise in inpainting these lesions, most existing methods operate…

Image and Video Processing · Electrical Eng. & Systems 2026-03-09 Zahra Karimaghaloo , Dumitru Fetco , Haz-Edine Assemlal , Hassan Rivaz , Douglas L. Arnold

Explainable artificial intelligence (XAI) methods have been proposed to interpret model decisions in classification and, more recently, in semantic segmentation. However, instance-level XAI for semantic segmentation, namely explanations…

Multiple sclerosis (MS) is a demyelinating disease that affects more than 2 million people worldwide. The most used imaging technique to help in its diagnosis and follow-up is magnetic resonance imaging (MRI). Fluid Attenuated Inversion…

Computer Vision and Pattern Recognition · Computer Science 2018-07-26 Paulo G. L. Freire , Ricardo J. Ferrari

To date, several methods have been developed to explain deep learning algorithms for classification tasks. Recently, an adaptation of two of such methods has been proposed to generate instance-level explainable maps in a semantic…

Neuropathic pain, affecting up to 10% of adults, remains difficult to treat due to limited therapeutic efficacy and tolerability. Although resting-state functional MRI (rs-fMRI) is a promising non-invasive measurement of brain biomarkers to…

Machine Learning · Computer Science 2025-03-04 Wenrui Fan , L. M. Riza Rizky , Jiayang Zhang , Chen Chen , Haiping Lu , Kevin Teh , Dinesh Selvarajah , Shuo Zhou

Black-box deep learning approaches have showcased significant potential in the realm of medical image analysis. However, the stringent trustworthiness requirements intrinsic to the medical field have catalyzed research into the utilization…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Yequan Bie , Luyang Luo , Hao Chen

We introduce MATEX (Multi-scale Attention and Text-guided Explainability), a novel framework that advances interpretability in medical vision-language models by incorporating anatomically informed spatial reasoning. MATEX synergistically…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Muhammad Imran , Chi Lee , Yugyung Lee

Knee osteoarthritis frequently exhibits discordance between structural damage observed in imaging and patient-reported symptoms such as pain. This mismatch complicates clinical interpretation and patient stratification and remains…

Machine Learning · Computer Science 2026-04-21 Pegah Ahadian , Mingrui Yang , Sixu Chen , Xiaojuan Li , Qiang Guan