English
Related papers

Related papers: Automated Protein Motif Localization using Concept…

200 papers

With a growing interest in understanding neural network prediction strategies, Concept Activation Vectors (CAVs) have emerged as a popular tool for modeling human-understandable concepts in the latent space. Commonly, CAVs are computed by…

Computer Vision and Pattern Recognition · Computer Science 2025-05-08 Frederik Pahde , Maximilian Dreyer , Leander Weber , Moritz Weckbecker , Christopher J. Anders , Thomas Wiegand , Wojciech Samek , Sebastian Lapuschkin

Vision-language models (VLMs) are capable of recognizing unseen actions. However, existing VLMs lack intrinsic understanding of procedural action concepts. Hence, they overfit to fixed labels and are not invariant to unseen action synonyms.…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Reza Ghoddoosian , Nakul Agarwal , Isht Dwivedi , Behzad Darisuh

Computational biology and bioinformatics provide vast data gold-mines from protein sequences, ideal for Language Models taken from NLP. These LMs reach for new prediction frontiers at low inference costs. Here, we trained two…

Understanding the relationships between protein sequence, structure and function is a long-standing biological challenge with manifold implications from drug design to our understanding of evolution. Recently, protein language models have…

Quantitative Methods · Quantitative Biology 2024-01-29 Dexiong Chen , Philip Hartout , Paolo Pellizzoni , Carlos Oliver , Karsten Borgwardt

Language Models (LMs) excel in understanding textual descriptions of proteins, as evident in biomedical question-answering tasks. However, their capability falters with raw protein data, such as amino acid sequences, due to a deficit in…

Quantitative Methods · Quantitative Biology 2024-05-22 Zhiyuan Liu , An Zhang , Hao Fei , Enzhi Zhang , Xiang Wang , Kenji Kawaguchi , Tat-Seng Chua

Prompt learning has emerged as an efficient alternative for fine-tuning foundational models, such as CLIP, for various downstream tasks. However, there is no work that provides a comprehensive explanation for the working mechanism of the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Shuailei Ma , Chen-Wei Xie , Ying Wei , Siyang Sun , Jiaqi Fan , Xiaoyi Bao , Yuxin Guo , Yun Zheng

While Pre-trained Language Models (PLMs) internalize a great amount of world knowledge, they have been shown incapable of recalling these knowledge to solve tasks requiring complex & multi-step reasoning. Similar to how humans develop a…

Computation and Language · Computer Science 2022-10-25 Boshi Wang , Xiang Deng , Huan Sun

As powerful pre-trained vision-language models (VLMs) like CLIP gain prominence, numerous studies have attempted to combine VLMs for downstream tasks. Among these, prompt learning has been validated as an effective method for adapting to…

Computer Vision and Pattern Recognition · Computer Science 2024-09-19 Yu Du , Tong Niu , Rong Zhao

Prior studies have made significant progress in image inpainting guided by either text description or subject image. However, the research on inpainting with flexible guidance or control, i.e., text-only, image-only, and their combination,…

Computer Vision and Pattern Recognition · Computer Science 2025-01-23 Yulin Pan , Chaojie Mao , Zeyinzi Jiang , Zhen Han , Jingfeng Zhang , Xiangteng He

Current protein language models (PLMs) learn protein representations mainly based on their sequences, thereby well capturing co-evolutionary information, but they are unable to explicitly acquire protein functions, which is the end goal of…

Biomolecules · Quantitative Biology 2023-07-06 Minghao Xu , Xinyu Yuan , Santiago Miret , Jian Tang

The prediction of amyloidogenicity in peptides and proteins remains a focal point of ongoing bioinformatics. The crucial step in this field is to apply advanced computational methodologies. Many recent approaches to predicting…

Machine Learning · Computer Science 2025-08-19 Zohra Yagoub , Hafida Bouziane

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

Machine Learning · Computer Science 2021-12-08 Yijia Xiao , Jiezhong Qiu , Ziang Li , Chang-Yu Hsieh , Jie Tang

The goal of this work is to establish a scalable pipeline for expanding an object detector towards novel/unseen categories, using zero manual annotations. To achieve that, we make the following four contributions: (i) in pursuit of…

Computer Vision and Pattern Recognition · Computer Science 2022-07-19 Chengjian Feng , Yujie Zhong , Zequn Jie , Xiangxiang Chu , Haibing Ren , Xiaolin Wei , Weidi Xie , Lin Ma

Vision-language models (VLMs) like CLIP have been adapted for Multi-Label Recognition (MLR) with partial annotations by leveraging prompt-learning, where positive and negative prompts are learned for each class to associate their embeddings…

Computer Vision and Pattern Recognition · Computer Science 2024-09-16 Samyak Rawlekar , Shubhang Bhatnagar , Narendra Ahuja

We present a unified, promptable model capable of simultaneously segmenting, recognizing, and captioning anything. Unlike SAM, we aim to build a versatile region representation in the wild via visual prompting. To achieve this, we train a…

Computer Vision and Pattern Recognition · Computer Science 2024-07-18 Ting Pan , Lulu Tang , Xinlong Wang , Shiguang Shan

Vision-Language Models (VLMs) have demonstrated impressive world knowledge across a wide range of tasks, making them promising candidates for embodied reasoning applications. However, existing benchmarks primarily evaluate the embodied…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Haotian Xue , Yunhao Ge , Yu Zeng , Zhaoshuo Li , Ming-Yu Liu , Yongxin Chen , Jiaojiao Fan

Projecting visual features into word embedding space has become a significant fusion strategy adopted by Multimodal Large Language Models (MLLMs). However, its internal mechanisms have yet to be explored. Inspired by multilingual research,…

Computation and Language · Computer Science 2025-05-21 Jiahao Huo , Yibo Yan , Boren Hu , Yutao Yue , Xuming Hu

In sequence-based predictions, conventionally an input sequence is represented by a multiple sequence alignment (MSA) or a representation derived from MSA, such as a position-specific scoring matrix. Recently, inspired by the development in…

Quantitative Methods · Quantitative Biology 2021-10-18 Nabil Ibtehaz , Daisuke Kihara

Generative modeling has become a central paradigm in protein research, extending machine learning beyond structure prediction toward sequence design, backbone generation, inverse folding, and biomolecular interaction modeling. However, the…

Machine Learning · Computer Science 2026-03-30 Senura Hansaja Wanasekara , Minh-Duong Nguyen , Xiaochen Liu , Nguyen H. Tran , Ken-Tye Yong

Large pretrained vision-language models like CLIP have shown promising generalization capability, but may struggle in specialized domains (e.g., satellite imagery) or fine-grained classification (e.g., car models) where the visual concepts…

Machine Learning · Computer Science 2024-11-01 Chen Huang , Skyler Seto , Samira Abnar , David Grangier , Navdeep Jaitly , Josh Susskind