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Metabolic networks, formed by a series of metabolic pathways, are made of intracellular and extracellular reactions that determine the biochemical properties of a cell, and by a set of interactions that guide and regulate the activity of…

Logic in Computer Science · Computer Science 2020-08-24 Jean-Marc Alliot , Marta Cialdea Mayer , Robert Demolombe , Martín Diéguez , Luis Fariñas del Cerro

The rate-limiting step of some enzymatic reactions is a physical step, i.e. diffusion. The efficiency of such reactions can be improved through an increase in the arrival rate of the substrate molecules, e.g. by a directed passage of…

Biological Physics · Physics 2007-05-23 Mehrdad Ghaemi , Nasrollah Rezaei-Ghaleh , Mohammad-Nabi Sarbolouki

For the theoretical understanding of the reactivity of complex chemical systems accurate relative energies between intermediates and transition states are required. Despite its popularity, density functional theory (DFT) often fails to…

Chemical Physics · Physics 2016-06-23 Gregor N. Simm , Markus Reiher

Information processing relying on biochemical interactions in the cellular environment is essential for biological organisms. The implementation of molecular computational systems holds significant interest and potential in the fields of…

Dynamical Systems · Mathematics 2023-12-01 Yuzhen Fan , Xiaoyu Zhang , Chuanhou Gao , Denis Dochain

Existing multi-agent path finding (MAPF) solvers do not account for uncertain behavior of uncontrollable agents. We present a novel variant of Enhanced Conflict-Based Search (ECBS), for both one-shot and lifelong MAPF in dynamic…

Multiagent Systems · Computer Science 2025-07-31 Kegan J. Strawn , Thomy Phan , Eric Wang , Nora Ayanian , Sven Koenig , Lars Lindemann

With the increasing complexity of modern industrial automatic and robotic systems, an increasing burden is put on the operators, who are requested to supervise and interact with such complex systems, typically under challenging and…

Human-Computer Interaction · Computer Science 2020-03-06 Lorenzo Sabattini , Valeria Villani , Julia N. Czerniak , Frieder Loch , Alexander Mertens , Birgit Vogel-Heuser , Cesare Fantuzzi

Multi-agent systems often operate under feedback, adaptation, and non-stationarity, yet many simulation studies retain static decision rules and fixed control parameters. This paper introduces a general adaptive multi-agent learning…

Multiagent Systems · Computer Science 2025-11-26 Roberto Garrone

Determining the exponentially scaled ground state wavefunction and the associated molecular properties remains one of the central challenges in quantum chemistry. Hybrid quantum-classical algorithms implemented on quantum computers offer a…

Quantum Physics · Physics 2026-04-22 Dibyendu Mondal , Ashish Kumar Patra , Rahul Maitra

Transformers have recently emerged as a significant force in the field of image deraining. Existing image deraining methods utilize extensive research on self-attention. Though showcasing impressive results, they tend to neglect critical…

Computer Vision and Pattern Recognition · Computer Science 2024-02-08 Yuhong He , Aiwen Jiang , Lingfang Jiang , Zhifeng Wang , Lu Wang

We report a method to convert discrete representations of molecules to and from a multidimensional continuous representation. This model allows us to generate new molecules for efficient exploration and optimization through open-ended…

We discuss the ``soft-ratcheting'' algorithm which generates targeted stochastic trajectories in molecular systems with scores corresponding to their probabilities. The procedure, which requires no initial pathway guess, is capable of…

Chemical Physics · Physics 2007-05-23 Daniel M. Zuckerman , Thomas B. Woolf

Mean-field molecular dynamics based on path integrals is used to approximate canonical quantum observables for particle systems consisting of nuclei and electrons. A computational bottleneck is the sampling from the Gibbs density of the…

Numerical Analysis · Mathematics 2023-11-30 Xin Huang , Petr Plechac , Mattias Sandberg , Anders Szepessy

There is a lack of scalable quantitative measures of reactivity for functional groups in organic chemistry. Measuring reactivity experimentally is costly and time-consuming and does not scale to the astronomical size of chemical space. In…

Computational Physics · Physics 2021-03-29 Mohammadamin Tavakoli , Aaron Mood , David Van Vranken , Pierre Baldi

Scene graphs -- objects as nodes and visual relationships as edges -- describe the whereabouts and interactions of the things and stuff in an image for comprehensive scene understanding. To generate coherent scene graphs, almost all…

Computer Vision and Pattern Recognition · Computer Science 2019-08-12 Long Chen , Hanwang Zhang , Jun Xiao , Xiangnan He , Shiliang Pu , Shih-Fu Chang

The evolution of a system of chemical reactions can be studied, in the eikonal approximation, by means of a Hamiltonian dynamical system. The fixed points of this dynamical system represent the different states in which the chemical system…

Statistical Mechanics · Physics 2009-11-13 Carlos Escudero , Jose Angel Rodriguez

Complex systems can be advantageously modeled by formal reaction systems (RS), a.k.a. chemical reaction networks in chemistry. Reaction-based models can indeed be interpreted in a hierarchy of semantics, depending on the question at hand,…

Molecular Networks · Quantitative Biology 2024-06-27 Hugo Buscemi , François Fages

Computational high-throughput virtual screening is essential for identifying redox-active molecules for sustainable applications such as electrochemical carbon capture. A primary challenge in this approach is the high computational cost…

Chemical Physics · Physics 2026-01-19 Yicheng Chen , Lixue Cheng , Yan Jing , Peichen Zhong

Motivation: A Chemical Reaction Network (CRN) is a set of chemical reactions, which can be very complex and difficult to analyze. Indeed, dynamical properties of CRNs can be described by a set of non-linear differential equations that…

Computational Engineering, Finance, and Science · Computer Science 2021-07-02 Lucia Nasti , Roberta Gori , Paolo Milazzo , Federico Poloni

Recently, numerous handcrafted and searched networks have been applied for semantic segmentation. However, previous works intend to handle inputs with various scales in pre-defined static architectures, such as FCN, U-Net, and DeepLab…

Computer Vision and Pattern Recognition · Computer Science 2020-03-24 Yanwei Li , Lin Song , Yukang Chen , Zeming Li , Xiangyu Zhang , Xingang Wang , Jian Sun

Differentiable physics simulation provides an avenue to tackle previously intractable challenges through gradient-based optimization, thereby greatly improving the efficiency of solving robotics-related problems. To apply differentiable…

Robotics · Computer Science 2025-04-08 Min Liu , Gang Yang , Siyuan Luo , Lin Shao