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Large language models (LLMs) are increasingly grounded in sensor data to perceive and reason about human physiology and the physical world. However, accurately interpreting heterogeneous multimodal sensor data remains a fundamental…

Artificial Intelligence · Computer Science 2026-01-13 Hyungjun Yoon , Mohammad Malekzadeh , Sung-Ju Lee , Fahim Kawsar , Lorena Qendro

Early detection of pulmonary nodules in computed tomography (CT) images is essential for successful outcomes among lung cancer patients. Much attention has been given to deep convolutional neural network (DCNN)-based approaches to this…

Computer Vision and Pattern Recognition · Computer Science 2019-03-26 Hao Tang , Daniel R. Kim , Xiaohui Xie

Machine learning approaches hold great potential for the automated detection of lung nodules in chest radiographs, but training the algorithms requires vary large amounts of manually annotated images, which are difficult to obtain. Weak…

Medical Large Vision-Language Models (Med-LVLMs) have shown strong potential in multimodal diagnostic tasks. However, existing single-agent models struggle to generalize across diverse medical specialties, limiting their performance. Recent…

Machine Learning · Computer Science 2026-01-27 Peng Xia , Jinglu Wang , Yibo Peng , Kaide Zeng , Zihan Dong , Xian Wu , Xiangru Tang , Hongtu Zhu , Yun Li , Linjun Zhang , Shujie Liu , Yan Lu , Huaxiu Yao

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. Early and precise diagnosis of AD is crucial for timely intervention and treatment planning to alleviate the progressive neurodegeneration. However, most…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 Wenlong Hou , Guangqian Yang , Ye Du , Yeung Lau , Lihao Liu , Junjun He , Ling Long , Shujun Wang

Large language models (LLMs) have demonstrated notable potential in medical applications, yet they face substantial challenges in handling complex real-world clinical diagnoses using conventional prompting methods. Current prompt…

Artificial Intelligence · Computer Science 2026-03-02 Wenliang Li , Rui Yan , Xu Zhang , Li Chen , Hongji Zhu , Jing Zhao , Junjun Li , Mengru Li , Wei Cao , Zihang Jiang , Wei Wei , Kun Zhang , Shaohua Kevin Zhou

Accurate lung nodule segmentation is crucial for early-stage lung cancer diagnosis, as it can substantially enhance patient survival rates. Computed tomography (CT) images are widely employed for early diagnosis in lung nodule analysis.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-11 Muhammad Usman , Azka Rehman , Abd Ur Rehman , Abdullah Shahid , Tariq Mahmood Khan , Imran Razzak , Minyoung Chung , Yeong Gil Shin

Lung cancer is the leading cause of cancer deaths. Early detection through low-dose computed tomography (CT) screening has been shown to significantly reduce mortality but suffers from a high false positive rate that leads to unnecessary…

Image and Video Processing · Electrical Eng. & Systems 2019-06-04 Jason L. Causey , Yuanfang Guan , Wei Dong , Karl Walker , Jake A. Qualls , Fred Prior , Xiuzhen Huang

In this paper we introduce ResearchCodeAgent, a novel multi-agent system leveraging large language models (LLMs) agents to automate the codification of research methodologies described in machine learning literature. The system bridges the…

Software Engineering · Computer Science 2025-05-06 Shubham Gandhi , Dhruv Shah , Manasi Patwardhan , Lovekesh Vig , Gautam Shroff

Pulmonary nodule detection, false positive reduction and segmentation represent three of the most common tasks in the computeraided analysis of chest CT images. Methods have been proposed for eachtask with deep learning based methods…

Computer Vision and Pattern Recognition · Computer Science 2019-07-29 Hao Tang , Chupeng Zhang , Xiaohui Xie

Lung cancer, a severe form of malignant tumor that originates in the tissues of the lungs, can be fatal if not detected in its early stages. It ranks among the top causes of cancer-related mortality worldwide. Detecting lung cancer manually…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Santanu Roy , Shweta Singh , Palak Sahu , Ashvath Suresh , Debashish Das

Purpose: Lung nodule segmentation, i.e., the algorithmic delineation of the lung nodule surface, is a fundamental component of computational nodule analysis pipelines. We propose a new method for segmentation that is a machine learning…

Image and Video Processing · Electrical Eng. & Systems 2021-01-20 Matthew C Hancock , Jerry F Magnan

Document Question Answering (DocQA) is a very common task. Existing methods using Large Language Models (LLMs) or Large Vision Language Models (LVLMs) and Retrieval Augmented Generation (RAG) often prioritize information from a single…

Machine Learning · Computer Science 2025-03-19 Siwei Han , Peng Xia , Ruiyi Zhang , Tong Sun , Yun Li , Hongtu Zhu , Huaxiu Yao

Differential Diagnosis (DDx) is a fundamental yet complex aspect of clinical decision-making, in which physicians iteratively refine a ranked list of possible diseases based on symptoms, antecedents, and medical knowledge. While recent…

Computation and Language · Computer Science 2025-06-16 Daniel Rose , Chia-Chien Hung , Marco Lepri , Israa Alqassem , Kiril Gashteovski , Carolin Lawrence

Survival analysis is critical for cancer prognosis and treatment planning, yet existing methods lack the transparency essential for clinical adoption. While recent pathology agents have demonstrated explainability in diagnostic tasks, they…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Guolin Huang , Wenting Chen , Jiaqi Yang , Xinheng Lyu , Xiaoling Luo , Sen Yang , Xiaohan Xing , Linlin Shen

Medical images from different healthcare centers exhibit varied data distributions, posing significant challenges for adapting lung nodule detection due to the domain shift between training and application phases. Traditional unsupervised…

Computer Vision and Pattern Recognition · Computer Science 2024-08-05 Haifeng Zhao , Lixiang Jiang , Leilei Ma , Dengdi Sun , Yanping Fu

Objective: Although medical imaging datasets are increasingly available, abnormal and annotation-intensive findings critical to lung cancer screening, particularly small pulmonary nodules, remain underrepresented and inconsistently curated.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Fakrul Islam Tushar , Ehsan Samei , Cynthia Rudin , Joseph Y. Lo

Recent advancements in medical Large Language Models (LLMs) have showcased their powerful reasoning and diagnostic capabilities. Despite their success, current unified multimodal medical LLMs face limitations in knowledge update costs,…

Computation and Language · Computer Science 2025-06-25 Yucheng Zhou , Lingran Song , Jianbing Shen

Recent progress in Large Language Models (LLMs) has drawn attention to their potential for accelerating drug discovery. However, a central problem remains: translating theoretical ideas into robust implementations in the highly specialized…

Machine Learning · Computer Science 2025-03-06 Sizhe Liu , Yizhou Lu , Siyu Chen , Xiyang Hu , Jieyu Zhao , Yingzhou Lu , Yue Zhao

Deep learning, as a promising new area of machine learning, has attracted a rapidly increasing attention in the field of medical imaging. Compared to the conventional machine learning methods, deep learning requires no hand-tuned feature…

Quantitative Methods · Quantitative Biology 2016-11-29 He Yang , Hengyong Yu , Ge Wang