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In X-ray imaging, photons are transmitted through and absorbed by the subject, but are also scattered in significant quantities. Previous attempts to use scattered photons for biological imaging used pencil or fan beam illumination. Here we…

When treating moving tumors, the precise delivery of proton therapy by pencil beam scanning (PBS) is challenged by the interplay effect. Although several 4D-optimization methods have been proposed, what is the most beneficial motion…

Medical Physics · Physics 2025-01-29 Ivar Bengtsson , Anders Forsgren , Albin Fredriksson

Generalization to previously unseen images with potential domain shifts and different styles is essential for clinically applicable medical image segmentation, and the ability to disentangle domain-specific and domain-invariant features is…

Computer Vision and Pattern Recognition · Computer Science 2022-11-23 Ran Gu , Guotai Wang , Jiangshan Lu , Jingyang Zhang , Wenhui Lei , Yinan Chen , Wenjun Liao , Shichuan Zhang , Kang Li , Dimitris N. Metaxas , Shaoting Zhang

Motivated by the need for low electron dose transmission electron microscopy imaging, we report the optimal frame dose (i.e. $e^-/A^{2}$) range for object detection and segmentation tasks with neural networks. The MSD-net architecture shows…

We discuss a novel paradigm in the optical readout of scintillation radiation detectors. In one common configuration, such detectors are homogeneous and the scintillation light is collected and recorded by external photodetectors. It is…

Instrumentation and Detectors · Physics 2018-03-28 Jacopo Dalmasson , Giorgio Gratta , Ako Jamil , Scott Kravitz , Milad Malek , Kevin Wells , Julie Bentley , Samuel Steven , Jiani Su

To accurately verify the dose of intensity-modulated radiation therapy (IMRT), we have used a global optimization method to investigate a new dose-verification algorithm. In practical application of this quality assurance (QA) procedure,…

Medical Physics · Physics 2007-05-23 Dong Hyun Park , Sung-Yong Park , Dahl Park , Tae-Hyun Kim , Kyung Hwan Shin , Dae Yong Kim , Kwan-Ho Cho

A novel data-processing method was developed to facilitate scintillation detector characterization. Combined with fan-beam calibration, this method can be used to quickly and conveniently calibrate gamma-ray detectors for SPECT, PET,…

Instrumentation and Detectors · Physics 2021-06-24 Xin Li , Li Tao , Craig S. Levin , Lars R. Furenlid

The purpose of this study was to find the most accurate model for radiochromic film dosimetry by comparing different channel independent perturbation models. A model selection approach based on (algorithmic) information theory was followed,…

Medical Physics · Physics 2015-05-05 Ignasi Méndez

Current clinical PET systems utilize detectors where the scintillator typically contains single elements of 3 - 6 mm width and about 20 mm height. While providing good TOF performance, this design limits the spatial resolution and causes…

Instrumentation and Detectors · Physics 2022-11-17 Florian Mueller , Stephan Naunheim , Yannick Kuhl , David Schug , Torsten Solf , Volkmar Schulz

Poor performance of quantitative analysis in histopathological Whole Slide Images (WSI) has been a significant obstacle in clinical practice. Annotating large-scale WSIs manually is a demanding and time-consuming task, unlikely to yield the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Sarah Cechnicka , James Ball , Hadrien Reynaud , Callum Arthurs , Candice Roufosse , Bernhard Kainz

Laser light scattering systems with volume Bragg grating (VBG) filters, which act as a spectral/angular filter, have often been used as a point measurement technique with spatial resolution as low as a few hundred um defined by the beam…

Treatment planning, which is a critical component of the radiotherapy workflow, is typically carried out by a medical physicist in a time-consuming trial-and-error manner. Previous studies have proposed knowledge-based or…

Image and Video Processing · Electrical Eng. & Systems 2024-03-29 Yiwen Zhang , Chuanpu Li , Liming Zhong , Zeli Chen , Wei Yang , Xuetao Wang

Diffuse Reflectance Spectroscopy (DRS) is a well-established optical technique for tissue composition assessment which has been clinically evaluated for tumour detection to ensure the complete removal of cancerous tissue. While point-wise…

Robotics · Computer Science 2025-03-12 Kaizhong Deng , Christopher J. Peters , George P. Mylonas , Daniel S. Elson

Adaptive radiation therapy (ART) seeks to maintain accurate dose delivery by monitoring anatomical changes during treatment and modifying plans accordingly, yet commonly used approaches for estimating cumulative dose rely on heuristic,…

Medical Physics · Physics 2026-03-03 Robert Boyd , Wolfgang A. Tomé

Compact radio sources such as pulsars and FRBs undergo scintillation in the interstellar medium (ISM) when scattered images interfere at the observer. ``Scintillometry'' refers to the range of techniques to extract astrometric information…

High Energy Astrophysical Phenomena · Physics 2026-01-30 Dylan L. Jow , Delon Shen

A new strategy for radiation therapy dosimetry planning (RTDP) used to reduce dose estimation errors due to respiratory motion in breast treatment was illustrated and evaluated in this study. On CT data set acquired for breast treatment,…

Medical Physics · Physics 2021-10-20 Mazen Moussallem , Pauline Harb , Hanane Rima , Zeina Al Kattar , Saad Ayoubi

Charged Particle Therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbons. A critical issue is the monitoring of the dose released by the beam to the tumor and to the surrounding tissues. We present…

A scintillating fiber array measurement system for gross beta is developed to achieve real-time monitoring of radioactivity in drinking water. The detector consists of 1,096 scintillating fibers, both sides of the fibers connect to a…

Instrumentation and Detectors · Physics 2017-07-20 Wenhui Lu , Hongchang Yi , Tongqing Liu , Zhi Zeng , Junli Li , Hui Zhang , Hao Ma

Purpose: Retinoblastoma (RB) is the most common eye tumor in childhood and can be treated external radiotherapy. The purpose of this work is to evaluate the adequacy of Monte Carlo simulations and the accuracy of a commercial treatment…

Medical Physics · Physics 2018-09-26 L. Brualla , P. A. Mayorga , A. Flühs , A. M. Lallena , J. Sempau , W. Sauerwein

Wide-field high-resolution microscopy requires fast scanning and accurate image mosaicking to cover large fields of view without compromising image quality. However, conventional galvanometric scanning, particularly under sinusoidal…

Image and Video Processing · Electrical Eng. & Systems 2026-02-04 Ziyi Huang , Rosalinda Xiong , Yaning Wang , Jinglun Yu , Jin U. Kang
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