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Introduction: Circadian rhythm disruption has garnered significant attention for its adverse effects on human health, particularly in reproductive medicine and fetal well-being. Assessing pregnancy health often relies on diagnostic markers…
Blood oxygen level dependent (BOLD) MRI time series with maternal hyperoxia can assess placental oxygenation and function. Measuring precise BOLD changes in the placenta requires accurate temporal placental segmentation and is confounded by…
Background In vivo mechanical behaviour of the abdominal wall has been poorly characterised and important details are missing regarding the occurrence and post-operative recurrence rate of hernias which can be as high as 30 %. This study…
Weight at delivery is a standard cumulative measure of placental growth. But weight is a crude summary of other placental characteristics, such as the size and shape of the chorionic plate and the location of the umbilical cord insertion.…
Purpose: A combined diffusion-relaxometry MR acquisition and analysis pipeline for in-vivo human placenta, which allows for exploration of coupling between T2* and apparent diffusion coefficient (ADC) measurements in a sub 10 minute scan…
Purpose: To study placental function - both perfusion and an oxygenation surrogate (T2*)-simultaneously and quantitatively in-vivo. Methods: 15 pregnant women were scanned on a 3T MR scanner. For perfusion measurements, a velocity selective…
Purpose: To develop and evaluate a real-time method for automatic planning and measurement of fetal femur length - an important indicator of antenatal growth - during MRI. While routinely assessed by ultrasound, MRI-based femur length…
Fetal growth restriction (FGR) is a prevalent pregnancy condition characterised by failure of the fetus to reach its genetically predetermined growth potential. We explore the application of model fitting techniques, linear regression…
In utero diffusion MRI provides unique opportunities to non-invasively study the microstructure of tissue during fetal development. A wide range of developmental processes, such as the growth of white matter tracts in the brain, the…
[Purpose] To develop a fully automated semantic placenta segmentation model that integrates the U-Net and SegNeXt architectures through ensemble learning. [Methods] A total of 218 pregnant women with suspected placental anomalies who…
Our empirical modeling suggests that deformation of placental vascular growth is associated with abnormal placental chorionic surface shape. Altered chorionic surface shape is associated with lowered placental functional efficiency. We…
Blood oxygen level dependent (BOLD) MRI with maternal hyperoxia can assess oxygen transport within the placenta and has emerged as a promising tool to study placental function. Measuring signal changes over time requires segmenting the…
Early brain development is characterized by the formation of a highly organized structural connectome. The interconnected nature of this connectome underlies the brain's cognitive abilities and influences its response to diseases and…
There is a growing interest in using diffusion MRI to study the white matter tracts and structural connectivity of the fetal brain. Recent progress in data acquisition and processing suggests that this imaging modality has a unique role in…
Semantic contour detection is a challenging problem that is often met in medical imaging, of which placental image analysis is a particular example. In this paper, we investigate utero-placental interface (UPI) detection in 2D placental…
Purpose: To provide real-time quantitative organ-specific information - specifically placental and brain T2* - to allow optimization of the MR examination to the individual patient. Methods: A FIRE-based real-time setup segmenting placenta…
The fetal cortical plate undergoes drastic morphological changes throughout early in utero development that can be observed using magnetic resonance (MR) imaging. An accurate MR image segmentation, and more importantly a topologically…
The placenta plays a crucial role in fetal development. Automated 3D placenta segmentation from fetal EPI MRI holds promise for advancing prenatal care. This paper proposes an effective semi-supervised learning method for improving placenta…
Resting-state functional Magnetic Resonance Imaging (fMRI) is a powerful imaging technique for studying functional development of the brain in utero. However, unpredictable and excessive movement of fetuses has limited clinical application…
Ultrasound (US) can be used to assess brain development in newborns, as MRI is challenging due to immobilization issues, and may require sedation. Dilatation of the lateral ventricles in the brain is a risk factor for poorer…