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Chromosome analysis is vital for diagnosing genetic disorders and guiding cancer therapy decisions through the identification of somatic clonal aberrations. However, developing an AI model are hindered by the overwhelming complexity and…

Quantitative Methods · Quantitative Biology 2025-05-23 Changchun Yang , Weiqian Dai , Yilan Zhang , Siyuan Chen , Jingdong Hu , Junkai Su , Yuxuan Chen , Ao Xu , Na Li , Xin Gao , Yongguo Yu

The ability to quickly and accurately compute properties from atomic simulations is critical for advancing a large number of applications in chemistry and materials science including drug discovery, energy storage, and semiconductor…

nimCSO is a high-performance tool implementing several methods for selecting components (data dimensions) in compositional datasets, which optimize the data availability and density for applications such as machine learning. Making said…

Materials Science · Physics 2024-12-17 Adam M. Krajewski , Arindam Debnath , Wesley F. Reinhart , Allison M. Beese , Zi-Kui Liu

Developing improved predictive models for multi-molecular systems is crucial, as nearly every chemical product used results from a mixture of chemicals. While being a vital part of the industry pipeline, the chemical mixture space remains…

Multi-omics research has enhanced our understanding of cancer heterogeneity and progression. Investigating molecular data through multi-omics approaches is crucial for unraveling the complex biological mechanisms underlying cancer, thereby…

Framing the investigation of diverse cancers as a machine learning problem has recently shown significant potential in multi-omics analysis and cancer research. Empowering these successful machine learning models are the high-quality…

Genomics · Quantitative Biology 2025-06-17 Ziwei Yang , Rikuto Kotoge , Xihao Piao , Zheng Chen , Lingwei Zhu , Peng Gao , Yasuko Matsubara , Yasushi Sakurai , Jimeng Sun

Rational design of compounds with specific properties requires conceptual understanding and fast evaluation of molecular properties throughout chemical compound space (CCS) -- the huge set of all potentially stable molecules. Recent…

Chemical Physics · Physics 2019-12-02 O. Anatole von Lilienfeld , Klaus-Robert Müller , Alexandre Tkatchenko

Determining molecular abundances in astrophysical environments is crucial for interpreting observational data and constraining physical conditions in these regions. Chemical modelling tools are essential for simulating the complex processes…

Instrumentation and Methods for Astrophysics · Physics 2025-09-17 Luke Keyte , Jason Ran

Deep learning models that leverage large datasets are often the state of the art for modelling molecular properties. When the datasets are smaller (< 2000 molecules), it is not clear that deep learning approaches are the right modelling…

Computational Engineering, Finance, and Science · Computer Science 2022-12-07 Gary Tom , Riley J. Hickman , Aniket Zinzuwadia , Afshan Mohajeri , Benjamin Sanchez-Lengeling , Alan Aspuru-Guzik

Scaling data volume and diversity is critical for generalizing embodied intelligence. While synthetic data generation offers a scalable alternative to expensive physical data acquisition, existing pipelines remain fragmented and…

Ensuring reliable data collection in large-scale particle physics experiments demands Data Quality Monitoring (DQM) procedures to detect possible detector malfunctions and preserve data integrity. Traditionally, this resource-intensive task…

High Energy Physics - Experiment · Physics 2025-09-19 Arsenii Gavrikov , Julián García Pardiñas , Alberto Garfagnini

Entanglement preparation and signal accumulation are essential for quantum parameter estimation, which pose significant challenges to both theories and experiments. Here, we propose how to utilize chaotic dynamics in a periodically driven…

Quantum Physics · Physics 2021-02-17 Wenjie Liu , Min Zhuang , Bo Zhu , Jiahao Huang , Chaohong Lee

Even well-designed software systems suffer from chronic performance degradation, also named "software aging", due to internal (e.g. software bugs) and external (e.g. resource exhaustion) impairments. These chronic problems often fly under…

Other Computer Science · Computer Science 2015-02-04 Pengfei Chen , Yong Qi , Di Hou

The increasing volume and complexity of X-ray absorption spectroscopy (XAS) data generated at synchrotron facilities worldwide require robust infrastructure for data management, sharing, and analysis. This paper introduces the XAS Database…

Databases · Computer Science 2025-09-18 Denis Spasyuk

We present the Open Supernova Catalog, an online collection of observations and metadata for presently 36,000+ supernovae and related candidates. The catalog is freely available on the web (https://sne.space), with its main interface having…

Solar and Stellar Astrophysics · Physics 2017-01-25 James Guillochon , Jerod Parrent , Luke Zoltan Kelley , Raffaella Margutti

Supervised machine learning approaches have been increasingly used in accelerating electronic structure prediction as surrogates of first-principle computational methods, such as density functional theory (DFT). While numerous quantum…

Chemical Physics · Physics 2024-03-22 Haiyang Yu , Meng Liu , Youzhi Luo , Alex Strasser , Xiaofeng Qian , Xiaoning Qian , Shuiwang Ji

Atomic-level simulations are widely used to study biomolecules and their dynamics. A common goal in such studies is to compare simulations of a molecular system under several conditions -- for example, with various mutations or bound…

Biomolecules · Quantitative Biology 2025-01-07 Martin Vögele , Neil J. Thomson , Sang T. Truong , Jasper McAvity , Ulrich Zachariae , Ron O. Dror

Recent advances in machine learning force fields (MLFFs) are revolutionizing molecular simulations by bridging the gap between quantum-mechanical (QM) accuracy and the computational efficiency of mechanistic potentials. However, the…

Massive stars play a pivotal role in shaping their galactic surroundings due to their high luminosity and intense ionizing radiation. However, the precise mechanisms governing the formation of massive stars remain elusive. Complex organic…

We introduce the Computational 2D Materials Database (C2DB), which organises a variety of structural, thermodynamic, elastic, electronic, magnetic, and optical properties of around 1500 two-dimensional materials distributed over more than…