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An optical microscopic examination of thinly cut stained tissue on glass slides prepared from a FFPE tissue blocks is the gold standard for tissue diagnostics. In addition, the diagnostic abilities and expertise of any pathologist is…

The identification of lesion within medical image data is necessary for diagnosis, treatment and prognosis. Segmentation and classification approaches are mainly based on supervised learning with well-paired image-level or voxel-level…

Computer Vision and Pattern Recognition · Computer Science 2019-04-09 Liyan Sun , Jiexiang Wang , Yue Huang , Xinghao Ding , Hayit Greenspan , John Paisley

Although generative adversarial network (GAN) based style transfer is state of the art in histopathology color-stain normalization, they do not explicitly integrate structural information of tissues. We propose a self-supervised approach to…

Image and Video Processing · Electrical Eng. & Systems 2021-06-04 Dwarikanath Mahapatra , Behzad Bozorgtabar , Jean-Philippe Thiran , Ling Shao

Virtual staining, or in-silico-labeling, has been proposed to computationally generate synthetic fluorescence images from label-free images by use of deep learning-based image-to-image translation networks. In most reported studies,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-04 Sourya Sengupta , Jianquan Xu , Phuong Nguyen , Frank J. Brooks , Yang Liu , Mark A. Anastasio

It is a critical task to evalaute HER2 expression level accurately for breast cancer evaluation and targeted treatment therapy selection. However, the standard multi-step Immunohistochemistry (IHC) staining is resource-intensive, expensive,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-23 Peide Zhu , Linbin Lu , Zhiqin Chen , Xiong Chen

The automated analysis of medical images is currently limited by technical and biological noise and bias. The same source tissue can be represented by vastly different images if the image acquisition or processing protocols vary. For an…

Virtual stain transfer leverages computer-assisted technology to transform the histochemical staining patterns of tissue samples into other staining types. However, existing methods often lose detailed pathological information due to the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Haiyan Wei , Hangrui Xu , Bingxu Zhu , Yulian Geng , Aolei Liu , Wenfei Yin , Jian Liu

The use of accurate scanning transmission electron microscopy (STEM) image simulation methods require large computation times that can make their use infeasible for the simulation of many images. Other simulation methods based on linear…

Computer Vision and Pattern Recognition · Computer Science 2022-11-18 Nick Lawrence , Mingren Shen , Ruiqi Yin , Cloris Feng , Dane Morgan

Histology imaging is an important tool in medical diagnosis and research, enabling the examination of tissue structure and composition at the microscopic level. Understanding the underlying molecular mechanisms of tissue architecture is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-30 Ronald Xie , Kuan Pang , Sai W. Chung , Catia T. Perciani , Sonya A. MacParland , Bo Wang , Gary D. Bader

Automatic text recognition from ancient handwritten record images is an important problem in the genealogy domain. However, critical challenges such as varying noise conditions, vanishing texts, and variations in handwriting make the…

Computer Vision and Pattern Recognition · Computer Science 2019-10-15 Mostafa Karimi , Gopalkrishna Veni , Yen-Yun Yu

Contemporary benchmark methods for image inpainting are based on deep generative models and specifically leverage adversarial loss for yielding realistic reconstructions. However, these models cannot be directly applied on image/video…

Computer Vision and Pattern Recognition · Computer Science 2017-11-20 Avisek Lahiri , Arnav Jain , Prabir Kumar Biswas , Pabitra Mitra

Quantitative analysis of cell structures is essential for biomedical and pharmaceutical research. The standard imaging approach relies on fluorescence microscopy, where cell structures of interest are labeled by chemical staining…

Immunohistochemical (IHC) virtual staining is a task that generates virtual IHC images from H\&E images while maintaining pathological semantic consistency with adjacent slices. This task aims to achieve cross-domain mapping between…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Yue Peng , Bing Xiong , Fuqiang Chen , De Eybo , RanRan Zhang , Wanming Hu , Jing Cai , Wenjian Qin

The examination of histopathology images is considered to be the gold standard for the diagnosis and stratification of cancer patients. A key challenge in the analysis of such images is their size, which can run into the gigapixels and can…

Image and Video Processing · Electrical Eng. & Systems 2021-09-09 Joseph Boyd , Mykola Liashuha , Eric Deutsch , Nikos Paragios , Stergios Christodoulidis , Maria Vakalopoulou

Three-dimensional (3D) histopathology of unprocessed tissues has the potential to transform disease management by enabling volumetric characterization of tissue microarchitecture and in-vivo assessment. Back-illumination Interference…

Computer Vision and Pattern Recognition · Computer Science 2026-05-22 Anthony Song , Boyan Zhou , Mayank Golhar , Marisa Morakis , Alex Baras , Nicholas Durr

Foundation models trained with self-supervised learning (SSL) on large-scale histological images have significantly accelerated the development of computational pathology. These models can serve as backbones for region-of-interest (ROI)…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Jiawen Li , Jiali Hu , Xitong Ling , Yongqiang Lv , Yuxuan Chen , Yizhi Wang , Tian Guan , Yifei Liu , Yonghong He

In the field of Medical Imaging, extensive research has been dedicated to leveraging its potential in uncovering critical diagnostic features in patients. Artificial Intelligence (AI)-driven medical diagnosis relies on sophisticated machine…

Computer Vision and Pattern Recognition · Computer Science 2024-02-27 Xiaohui Chen , Tie Luo

Computer assisted diagnosis in digital pathology is becoming ubiquitous as it can provide more efficient and objective healthcare diagnostics. Recent advances have shown that the convolutional Neural Network (CNN) architectures, a…

Image and Video Processing · Electrical Eng. & Systems 2022-01-05 Sruthi Krishna , Suganthi S. S , Shivsubramani Krishnamoorthy , Arnav Bhavsar

Existing deep learning-based approaches for histopathology image analysis require large annotated training sets to achieve good performance; but annotating histopathology images is slow and resource-intensive. Conditional generative…

Image and Video Processing · Electrical Eng. & Systems 2021-10-29 Sujata Butte , Haotian Wang , Min Xian , Aleksandar Vakanski

Generative Adversarial Networks (GANs) have been at the forefront of image synthesis, especially in medical fields like histopathology, where they help address challenges such as data scarcity, patient privacy, and class imbalance. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-30 Osama Mustafa