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Patient matching is the process of linking patients to appropriate clinical trials by accurately identifying and matching their medical records with trial eligibility criteria. We propose LLM-Match, a novel framework for patient matching…

Computation and Language · Computer Science 2025-03-26 Xiaodi Li , Shaika Chowdhury , Chung Il Wi , Maria Vassilaki , Xiaoke Liu , Terence T Sio , Owen Garrick , Young J Juhn , James R Cerhan , Cui Tao , Nansu Zong

This paper presents the development and evaluation of a Retrieval-Augmented Generation (RAG) system for querying the United Kingdom's National Institute for Health and Care Excellence (NICE) clinical guidelines using Large Language Models…

Role-playing Large language models (LLMs) are increasingly deployed in high-stakes domains such as healthcare, education, and governance, where failures can directly impact user trust and well-being. A cost effective paradigm for LLM…

Computation and Language · Computer Science 2025-09-16 Timothy Rupprecht , Enfu Nan , Arash Akbari , Arman Akbari , Lei Lu , Priyanka Maan , Sean Duffy , Pu Zhao , Yumei He , David Kaeli , Yanzhi Wang

Large language models equipped with retrieval-augmented generation (RAG) represent a burgeoning field aimed at enhancing answering capabilities by leveraging external knowledge bases. Although the application of RAG with language-only…

Computer Vision and Pattern Recognition · Computer Science 2024-06-03 Cheng Tan , Jingxuan Wei , Linzhuang Sun , Zhangyang Gao , Siyuan Li , Bihui Yu , Ruifeng Guo , Stan Z. Li

Achieving human-level intelligence requires refining the transition from the fast, intuitive System 1 to the slower, more deliberate System 2 reasoning. While System 1 excels in quick, heuristic decisions, System 2 relies on logical…

Tool calling has become increasingly popular for Large Language Models (LLMs). However, for large tool sets, the resulting tokens would exceed the LLM's context window limit, making it impossible to include every tool. Hence, an external…

Computation and Language · Computer Science 2026-03-03 Saptarshi Sengupta , Zhengyu Zhou , Jun Araki , Xingbo Wang , Bingqing Wang , Suhang Wang , Zhe Feng

Reasoning language models (RLMs), also known as Large Reasoning Models (LRMs), such as OpenAI's o1 and o3, DeepSeek-R1, and Alibaba's QwQ, have redefined AI's problem-solving capabilities by extending LLMs with advanced reasoning…

Large Language Models (LLMs) have shown versatility in various Natural Language Processing (NLP) tasks, including their potential as effective question-answering systems. However, to provide precise and relevant information in response to…

Computation and Language · Computer Science 2024-09-09 Sriram Veturi , Saurabh Vaichal , Reshma Lal Jagadheesh , Nafis Irtiza Tripto , Nian Yan

Despite their remarkable natural language understanding capabilities, Large Language Models (LLMs) have been underutilized for retrieval tasks. We present Search-R3, a novel framework that addresses this limitation by adapting LLMs to…

Computation and Language · Computer Science 2026-04-10 Yuntao Gui , James Cheng

Patient-trial matching requires reasoning over long, heterogeneous electronic health records (EHRs) and complex eligibility criteria, posing significant challenges for scalability, generalization, and computational efficiency. Existing…

Computation and Language · Computer Science 2026-04-27 Xiaodi Li , Yang Xiao , Munhwan Lee , Konstantinos Leventakos , Young J. Juhn , David Jones , Terence T. Sio , Wei Liu , Maria Vassilaki , Nansu Zong

Large Language Models (LLMs) demonstrate human-level capabilities in dialogue, reasoning, and knowledge retention. However, even the most advanced LLMs face challenges such as hallucinations and real-time updating of their knowledge.…

Computation and Language · Computer Science 2024-09-10 Xuanwang Zhang , Yunze Song , Yidong Wang , Shuyun Tang , Xinfeng Li , Zhengran Zeng , Zhen Wu , Wei Ye , Wenyuan Xu , Yue Zhang , Xinyu Dai , Shikun Zhang , Qingsong Wen

Large language models (LLMs) exhibit remarkable capabilities across diverse tasks, yet aligning them efficiently and effectively with human expectations remains a critical challenge. This thesis advances LLM alignment by introducing novel…

Computation and Language · Computer Science 2025-06-12 Yuxin Jiang

Large language models face challenges in long-context question answering, where key evidence of a query may be dispersed across millions of tokens. Existing works equip large language models with a memory buffer that is dynamically updated…

Computation and Language · Computer Science 2026-03-03 Yaorui Shi , Yuxin Chen , Siyuan Wang , Sihang Li , Hengxing Cai , Qi Gu , Xiang Wang , An Zhang

Contemporary progress in large language models (LLMs) has revealed notable inferential capacities via reinforcement learning (RL) employing verifiable reward, facilitating the development of O1 and R1-like reasoning models. Directly…

Machine Learning · Computer Science 2025-10-21 Zexu Sun , Yongcheng Zeng , Erxue Min , Heyang Gao , Bokai Ji , Xu Chen

Large Language Models (LLMs) have shown strong capabilities in document re-ranking, a key component in modern Information Retrieval (IR) systems. However, existing LLM-based approaches face notable limitations, including ranking…

Information Retrieval · Computer Science 2025-10-03 Pinhuan Wang , Zhiqiu Xia , Chunhua Liao , Feiyi Wang , Hang Liu

Retrieval-augmented large language models (LLMs) leverage relevant content retrieved by information retrieval systems to generate correct responses, aiming to alleviate the hallucination problem. However, existing retriever-responder…

Computation and Language · Computer Science 2024-06-26 Taolin Zhang , Dongyang Li , Qizhou Chen , Chengyu Wang , Longtao Huang , Hui Xue , Xiaofeng He , Jun Huang

Recently, the number of off-the-shelf Large Language Models (LLMs) has exploded with many open-source options. This creates a diverse landscape regarding both serving options (e.g., inference on local hardware vs remote LLM APIs) and model…

Machine Learning · Computer Science 2024-12-18 Dimitrios Sikeridis , Dennis Ramdass , Pranay Pareek

Large language models (LLMs) have transformed AI research thanks to their powerful internal capabilities and knowledge. However, existing LLMs still fail to effectively incorporate the massive external knowledge when interacting with the…

Computation and Language · Computer Science 2026-04-15 Tao Feng , Pengrui Han , Guanyu Lin , Ge Liu , Jiaxuan You

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

Retrieval-Augmented Generation (RAG) utilizes external knowledge to augment Large Language Models' (LLMs) reliability. For flexibility, agentic RAG employs autonomous, multi-round retrieval and reasoning to resolve queries. Although recent…

Information Retrieval · Computer Science 2025-11-10 Chao Zhang , Yuhao Wang , Derong Xu , Haoxin Zhang , Yuanjie Lyu , Yuhao Chen , Shuochen Liu , Tong Xu , Xiangyu Zhao , Yan Gao , Yao Hu , Enhong Chen
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