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Neural network (NN) model chemistries (MCs) promise to facilitate the accurate exploration of chemical space and simulation of large reactive systems. One important path to improving these models is to add layers of physical detail,…

Chemical Physics · Physics 2018-04-04 John E. Herr , Kun Yao , Ryker McIntyre , David Toth , John Parkhill

Current Lagrangian (particle-tracking) algorithms used to simulate diffusion-reaction equations must employ a certain number of particles to properly emulate the system dynamics---particularly for imperfectly-mixed systems. The number of…

Numerical Analysis · Mathematics 2017-03-08 Michael Schmidt , Stephen Pankavich , David Benson

Hybrid quantum/molecular mechanics (QM/MM) models play a pivotal role in molecular simulations. These models provide a balance between accuracy, surpassing pure MM models, and computational efficiency, offering advantages over pure QM…

Computational Physics · Physics 2024-02-20 Yangshuai Wang , James R. Kermode , Christoph Ortner , Lei Zhang

We have extended the multilevel summation (MLS) method, originally developed to evaluate long-range Coulombic interactions in molecular dynamics (MD) simulations [Skeel et al., J. Comput. Chem., 23, 673 (2002)], to handle dispersion…

Materials Science · Physics 2014-01-16 Daniel Tameling , Paul Springer , Paolo Bientinesi , Ahmed E. Ismail

A novel strategy is proposed to improve the accuracy of state estimation and reconstruction from low-fidelity models and sparse data from sensors. This strategy combines ensemble Data Assimilation (DA) and Machine Learning (ML) tools,…

Fluid Dynamics · Physics 2025-01-31 Miguel M. Valero , Marcello Meldi

Molecular dynamics simulations are an important tool for describing the evolution of a chemical system with time. However, these simulations are inherently held back either by the prohibitive cost of accurate electronic structure theory…

Chemical Physics · Physics 2018-12-20 Michael Gastegger , Philipp Marquetand

We develop an online optimisation algorithm for in situ calibration of collision models in simulations of rarefied gas flows. The online optimised collision models are able to achieve similar accuracy to Direct Molecular Simulation (DMS) at…

Fluid Dynamics · Physics 2024-11-21 Nicholas Daultry Ball , Jonathan F. MacArt , Justin Sirignano

Organic reaction, the foundation of modern chemical industry, is crucial for new material development and drug discovery. However, deciphering reaction mechanisms and modeling multi-molecular relationships remain formidable challenges due…

Chemical Physics · Physics 2025-08-13 Lirong Wu , Junjie Wang , Zhifeng Gao , Xiaohong Ji , Rong Zhu , Xinyu Li , Linfeng Zhang , Guolin Ke , Weinan E

Quantum Computing (QC) offers outstanding potential for molecular characterization and drug discovery, particularly in solving complex properties like the Ground State Energy (GSE) of biomolecules. However, QC faces challenges due to…

Chemical Physics · Physics 2024-12-17 Laia Coronas Sala , Parfait Atchade-Adelemou

First principles based exploration of chemical space deepens our understanding of chemistry, and might help with the design of new materials or experiments. Due to the computational cost of quantum chemistry methods and the immens number of…

Chemical Physics · Physics 2020-08-18 Bing Huang , O. Anatole von Lilienfeld

Molecular Dynamics (MD) simulations are essential for understanding the atomic-level behavior of molecular systems, giving insights into their transitions and interactions. However, classical MD techniques are limited by the trade-off…

Biomolecules · Quantitative Biology 2026-04-21 Ziyang Yu , Wenbing Huang , Yang Liu

Errors in surface code have typically been decoded by Minimum Weight Perfect Matching (MWPM) based method. Recently, neural-network-based Machine Learning (ML) techniques have been employed for this purpose. Here we propose a two-level (low…

One of the grand challenges in modern theoretical chemistry is designing and implementing approximations that expedite ab initio methods without loss of accuracy. Machine learning (ML), in particular neural networks, are emerging as a…

Chemical Physics · Physics 2018-01-10 Justin S. Smith , Olexandr Isayev , Adrian E. Roitberg

Despite of their success, the results of first-principles quantum mechanical calculations contain inherent numerical errors caused by various approximations. We propose here a neural-network algorithm to greatly reduce these inherent…

Data Analysis, Statistics and Probability · Physics 2007-05-23 LiHong Hu , XiuJun Wang , LaiHo Wong , GuanHua Chen

Machine learning force fields (MLFFs) are gradually evolving towards enabling molecular dynamics simulations of molecules and materials with ab initio accuracy but at a small fraction of the computational cost. However, several challenges…

The computational prediction of the structure and stability of hybrid organic-inorganic interfaces provides important insights into the measurable properties of electronic thin film devices, coatings, and catalyst surfaces and plays an…

Computer simulation plays a central role in modern day materials science. The utility of a given computational approach depends largely on the balance it provides between accuracy and computational cost. Molecular crystals are a class of…

We propose an effective approach to rapid estimation of the energy spectrum of quantum systems with the use of machine learning (ML) algorithm. In the ML approach (back propagation), the wavefunction data known from experiments is…

Computational Physics · Physics 2020-01-29 Gennadiy Burlak

The limited extrapolative power of structure-based machine learning (ML) models is a critical bottleneck in chemical discovery, particularly for industrial R&D, where navigating uncharted chemical space to find next-generation materials or…

Machine learning has emerged as a powerful tool for predicting molecular properties in chemical reaction networks with reduced computational cost. However, accurately predicting energies of transition state (TS) structures remains a…

Chemical Physics · Physics 2025-04-29 Stefan Gugler , Markus Reiher
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