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Machine learning (ML) promises better clinical decision-making, yet opaque model behavior limits the adoption in healthcare. We propose two novel regularization techniques for ensuring the interpretability of ML models trained on real-world…

Machine Learning · Computer Science 2026-03-24 Salma Rachidi , Aso Bozorgpanah , Eric Fey , Alexander Jung

BACKGROUND: Atrial fibrillation (AF), the most common arrhythmia, is linked to high morbidity and mortality. In a fast-evolving AF rhythm control treatment era, predicting AF recurrence after its onset may be crucial to achieve the optimal…

Pulmonary hypertension (PH) is a condition of high blood pressure that affects the arteries in the lungs and the right side of the heart (Mayo Clinic, 2017). A mean pulmonary artery pressure greater than 25 mmHg is defined as Pulmonary…

Signal Processing · Electrical Eng. & Systems 2023-04-26 Eashan Kosaraju , Praveen Kumar Pandian Shanmuganathan

Extracting actionable insight from Electronic Health Records (EHRs) poses several challenges for traditional machine learning approaches. Patients are often missing data relative to each other; the data comes in a variety of modalities,…

Machine Learning · Computer Science 2018-11-13 Brandon Malone , Alberto Garcia-Duran , Mathias Niepert

Right heart failure (RHF) is a disease characterized by abnormalities in the structure or function of the right ventricle (RV), which is associated with high morbidity and mortality. Lung disease often causes increased right ventricular…

Machine Learning · Computer Science 2025-11-18 Bin Liu , Qinghao Zhao , Yuxi Zhou , Zhejun Sun , Kaijie Lei , Deyun Zhang , Shijia Geng , Shenda Hong

The right ventricular (RV) function deterioration strongly predicts clinical outcomes in numerous circumstances. To boost the clinical deployment of ensemble regression methods that quantify RV volumes using tabular data from the widely…

Tissues and Organs · Quantitative Biology 2024-03-13 Tuan A. Bohoran , Polydoros N. Kampaktsis , Laura McLaughlin , Jay Leb , Gerry P. McCann , Archontis Giannakidis

High Flow Nasal Cannula (HFNC) provides non-invasive respiratory support for critically ill children who may tolerate it more readily than other Non-Invasive (NIV) techniques. Timely prediction of HFNC failure can provide an indication for…

Machine Learning · Computer Science 2021-11-24 George A. Pappy , Melissa D. Aczon , Randall C. Wetzel , David R. Ledbetter

Patients have distinct information needs about their hospitalization that can be addressed using clinical evidence from electronic health records (EHRs). While artificial intelligence (AI) systems show promise in meeting these needs, robust…

Computation and Language · Computer Science 2026-03-31 Sarvesh Soni , Dina Demner-Fushman

Sepsis is a deadly condition affecting many patients in the hospital. Recent studies have shown that patients diagnosed with sepsis have significant mortality and morbidity, resulting from the body's dysfunctional host response to…

Machine Learning · Computer Science 2022-12-14 Ronald Moore , Rishikesan Kamaleswaran

Coronary Heart Disease affects millions of people worldwide and is a well-studied area of healthcare. There are many viable and accurate methods for the diagnosis and prediction of heart disease, but they have limiting points such as…

Artificial Intelligence · Computer Science 2024-09-24 Jamal Al-Karaki , Philip Ilono , Sanchit Baweja , Jalal Naghiyev , Raja Singh Yadav , Muhammad Al-Zafar Khan

Deep learning-based modeling of multimodal Electronic Health Records (EHRs) has become an important approach for clinical diagnosis and risk prediction. However, due to diverse clinical workflows and privacy constraints, raw EHRs are…

Machine Learning · Computer Science 2026-04-09 Bohao Li , Tao Zou , Junchen Ye , Yan Gong , Bowen Du

In this work we addressed the problem of capturing sequential information contained in longitudinal electronic health records (EHRs). Clinical notes, which is a particular type of EHR data, are a rich source of information and practitioners…

Computation and Language · Computer Science 2020-10-27 Andrey Kormilitzin , Nemanja Vaci , Qiang Liu , Hao Ni , Goran Nenadic , Alejo Nevado-Holgado

Biomedical image segmentation is critical for accurate identification and analysis of anatomical structures in medical imaging, particularly in cardiac MRI. Manual segmentation is labor-intensive, time-consuming, and prone to errors,…

Image and Video Processing · Electrical Eng. & Systems 2024-08-28 Ting Yu Tsai , Li Lin , Shu Hu , Ming-Ching Chang , Hongtu Zhu , Xin Wang

Homelessness among US veterans remains a critical public health challenge, yet risk prediction offers a pathway for proactive intervention. In this retrospective prognostic study, we analyzed electronic health record (EHR) data from…

Computation and Language · Computer Science 2026-02-04 Rohan Pandey , Haijuan Yan , Hong Yu , Jack Tsai

Traditional diagnosis of chronic diseases involves in-person consultations with physicians to identify the disease. However, there is a lack of research focused on predicting and developing application systems using clinical notes and blood…

Software Engineering · Computer Science 2024-06-27 Chun-Chieh Liao , Wei-Ting Kuo , I-Hsuan Hu , Yen-Chen Shih , Jun-En Ding , Feng Liu , Fang-Ming Hung

Structural heart disease (SHD) is a prevalent condition with many undiagnosed cases, and early detection is often limited by the high cost and accessibility constraints of echocardiography (ECHO). Recent studies show that artificial…

Applications · Statistics 2026-03-04 Ya Zhou , Zhaohong Sun , Tianxiang Hao , Xiangjie Li

Discharge summaries in Electronic Health Records (EHRs) are crucial for clinical decision-making, but their length and complexity make information extraction challenging, especially when dealing with accumulated summaries across multiple…

Computation and Language · Computer Science 2024-11-12 Sunjun Kweon , Jiyoun Kim , Heeyoung Kwak , Dongchul Cha , Hangyul Yoon , Kwanghyun Kim , Jeewon Yang , Seunghyun Won , Edward Choi

The utilization of Electronic Health Records (EHRs) for clinical risk prediction is on the rise. However, strict privacy regulations limit access to comprehensive health records, making it challenging to apply standard machine learning…

Computation and Language · Computer Science 2023-12-08 Angeela Acharya , Sulabh Shrestha , Anyi Chen , Joseph Conte , Sanja Avramovic , Siddhartha Sikdar , Antonios Anastasopoulos , Sanmay Das

As standards of care advance, patients are living longer and once-fatal diseases are becoming manageable. Clinical trials increasingly focus on reducing disease burden, which can be quantified by the timing and occurrence of multiple…

Objective. Heart failure is one of the leading causes of death worldwide, with millions of deaths each year, according to data from the World Health Organization (WHO) and other public health agencies. While significant progress has been…

Machine Learning · Computer Science 2026-05-29 Jianzhou Chen , Jinyang Sun , Xiumei Wang , Xi Chen , Heyu Chu , Guo Song , Yuji Luo , Xingping Zhou , Rong Gu