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Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

The large-scale development of large language models (LLMs) in medical contexts, such as diagnostic assistance and treatment recommendations, necessitates that these models possess accurate medical knowledge and deliver traceable…

Artificial Intelligence · Computer Science 2025-08-12 Qiyuan Li , Haijiang Liu , Caicai Guo , Chao Gao , Deyu Chen , Meng Wang , Feng Gao , Frank van Harmelen , Jinguang Gu

Causal representation learning (CRL) has garnered increasing interest from the causal inference and artificial intelligence communities due to its potential to disentangle complex data-generating mechanism into causally interpretable latent…

Machine Learning · Statistics 2026-05-28 Hao Chen , Lin Liu , Yu Guang Wang

Current knowledge-enhanced large language models (LLMs) rely on static, pre-constructed knowledge bases that suffer from coverage gaps and temporal obsolescence, limiting their effectiveness in dynamic information environments. We present…

Machine Learning · Computer Science 2025-10-13 Jing Li , Zhijie Sun , Zhicheng Zhou , Suming Qiu , Junjie Huang , Haijia Sun , Linyuan Qiu

While Retrieval-Augmented Generation (RAG) has been swiftly adopted in scientific and clinical QA systems, a comprehensive evaluation benchmark in the medical domain is lacking. To address this gap, we introduce the Medical…

Computation and Language · Computer Science 2026-02-12 Liz Li , Wei Zhu

While humans naturally learn and adapt from past experiences, large language models (LLMs) and their agentic counterparts struggle to retain reasoning from previous tasks and apply them in future contexts. To address this limitation, we…

Computation and Language · Computer Science 2025-05-21 Peter Baile Chen , Yi Zhang , Dan Roth , Samuel Madden , Jacob Andreas , Michael Cafarella

Background: Retrieval augmented generation (RAG) technology can empower large language models (LLMs) to generate more accurate, professional, and timely responses without fine tuning. However, due to the complex reasoning processes and…

Computation and Language · Computer Science 2026-02-27 Jianmin Li , Ying Chang , Su-Kit Tang , Yujia Liu , Yanwen Wang , Shuyuan Lin , Binkai Ou

Medication adherence is critical for the recovery of adolescents and young adults (AYAs) who have undergone hematopoietic cell transplantation (HCT). However, maintaining adherence is challenging for AYAs after hospital discharge, who…

Machine Learning · Computer Science 2025-05-22 Ziping Xu , Hinal Jajal , Sung Won Choi , Inbal Nahum-Shani , Guy Shani , Alexandra M. Psihogios , Pei-Yao Hung , Susan Murphy

LLM unlearning is essential for mitigating safety, copyright, and privacy concerns in pre-trained large language models (LLMs). Compared to preference alignment, it offers a more explicit way by removing undesirable knowledge characterized…

Machine Learning · Computer Science 2026-03-12 Junfeng Liao , Qizhou Wang , Shanshan Ye , Xin Yu , Ling Chen , Zhen Fang

Retrieval-Augmented Generation (RAG) systems enhance response credibility and traceability by displaying reference contexts, but this transparency simultaneously introduces a novel black-box attack vector. Existing document poisoning…

Computation and Language · Computer Science 2026-01-27 Runqi Sui

In recent years, there has been substantial progress in using pretrained Language Models (LMs) on a range of tasks aimed at improving the understanding of biomedical texts. Nonetheless, existing biomedical LLMs show limited comprehension of…

Computation and Language · Computer Science 2025-09-10 Andrey Sakhovskiy , Elena Tutubalina

Large language models (LLMs) have shown superior performance without task-specific fine-tuning. Despite the success, the knowledge stored in the parameters of LLMs could still be incomplete and difficult to update due to the computational…

Computation and Language · Computer Science 2023-10-10 Yile Wang , Peng Li , Maosong Sun , Yang Liu

Combining large language models with logical reasoning enhances their capacity to address problems in a robust and reliable manner. Nevertheless, the intricate nature of logical reasoning poses challenges when gathering reliable data from…

Accurate healthcare prediction is critical for improving patient outcomes and reducing operational costs. Bolstered by growing reasoning capabilities, large language models (LLMs) offer a promising path to enhance healthcare predictions by…

Artificial Intelligence · Computer Science 2025-11-18 Chuang Zhao , Hui Tang , Hongke Zhao , Xiaofang Zhou , Xiaomeng Li

Reinforcement learning (RL) with rule-based reward functions has recently shown great promise in enhancing the reasoning depth and generalization ability of vision-language models (VLMs), while maintaining computational efficiency. In spite…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Yizhou Liu , Dingkang Yang , Zizhi Chen , Minghao Han , Xukun Zhang , Keliang Liu , Jingwei Wei , Lihua Zhang

Search-augmented reasoning agents interleave multi-step reasoning with external information retrieval, but uncontrolled retrieval often leads to redundant evidence, context saturation, and unstable learning. Existing approaches rely on…

Computation and Language · Computer Science 2026-02-03 Siheng Xiong , Oguzhan Gungordu , Blair Johnson , James C. Kerce , Faramarz Fekri

Large language models (LLMs) have demonstrated impressive capabilities and are receiving increasing attention to enhance their reasoning through scaling test--time compute. However, their application in open--ended, knowledge--intensive,…

Artificial Intelligence · Computer Science 2025-05-27 Yize Zhang , Tianshu Wang , Sirui Chen , Kun Wang , Xingyu Zeng , Hongyu Lin , Xianpei Han , Le Sun , Chaochao Lu

Retrieval augmented generation (RAG) has shown great power in improving Large Language Models (LLMs). However, most existing RAG-based LLMs are dedicated to retrieving single modality information, mainly text; while for many real-world…

Computation and Language · Computer Science 2025-06-09 Saptarshi Sengupta , Shuhua Yang , Paul Kwong Yu , Fali Wang , Suhang Wang

In recent years, accurately and quickly deploying medical large language models (LLMs) has become a trend. Among these, retrieval-augmented generation (RAG) has garnered attention due to rapid deployment and privacy protection. However, the…

Computation and Language · Computer Science 2025-08-06 Penglei Sun , Yixiang Chen , Xiang Li , Xiaowen Chu

Large Language Models (LLMs) excel at reasoning and generation but are inherently limited by static pretraining data, resulting in factual inaccuracies and weak adaptability to new information. Retrieval-Augmented Generation (RAG) addresses…

Computation and Language · Computer Science 2025-11-03 Qi Luo , Xiaonan Li , Yuxin Wang , Tingshuo Fan , Yuan Li , Xinchi Chen , Xipeng Qiu