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Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani

Retrieval-Augmented Generation (RAG) has become a powerful paradigm for enhancing large language models (LLMs) through external knowledge retrieval. Despite its widespread attention, existing academic research predominantly focuses on…

Information Retrieval · Computer Science 2024-10-31 Yiruo Cheng , Kelong Mao , Ziliang Zhao , Guanting Dong , Hongjin Qian , Yongkang Wu , Tetsuya Sakai , Ji-Rong Wen , Zhicheng Dou

Large Language Models (LLMs) integrated with Retrieval-Augmented Generation (RAG) techniques have exhibited remarkable performance across a wide range of domains. However, existing RAG approaches primarily operate on unstructured data and…

Artificial Intelligence · Computer Science 2026-04-22 Ge Chang , Jinbo Su , Jiacheng Liu , Pengfei Yang , Yuhao Shang , Huiwen Zheng , Hongli Ma , Yan Liang , Yuanchun Li , Yunxin Liu

Large Language Models (LLMs) encounter challenges with the unique syntax of specific domains, such as biomolecules. Existing fine-tuning or modality alignment techniques struggle to bridge the domain knowledge gap and understand complex…

Biomolecules · Quantitative Biology 2024-06-28 Jinzhe Liu , Xiangsheng Huang , Zhuo Chen , Yin Fang

Retrieval-Augmented Generation (RAG) enables large language models (LLMs) to access broader knowledge sources, yet factual inconsistencies persist due to noise in retrieved documents-even with advanced retrieval methods. We demonstrate that…

Computation and Language · Computer Science 2025-06-04 Yongjian Li , HaoCheng Chu , Yukun Yan , Zhenghao Liu , Shi Yu , Zheni Zeng , Ruobing Wang , Sen Song , Zhiyuan Liu , Maosong Sun

Large language model (LLM)-based evolution is a promising approach for open-ended discovery, where progress requires sustained search and knowledge accumulation. Existing methods still rely heavily on fixed heuristics and hard-coded…

Matching patients effectively and efficiently for clinical trials is a significant challenge due to the complexity and variability of patient profiles and trial criteria. This paper introduces \textbf{Multi-Agent for Knowledge Augmentation…

Multiagent Systems · Computer Science 2026-05-19 Hanwen Shi , Jin Zhang , Kunpeng Zhang

Despite the impressive performance of large language models (LLMs) pretrained on vast knowledge corpora, advancing their knowledge manipulation-the ability to effectively recall, reason, and transfer relevant knowledge-remains challenging.…

Computation and Language · Computer Science 2026-01-13 Qitan Lv , Tianyu Liu , Qiaosheng Zhang , Xingcheng Xu , Chaochao Lu

Retrieval-augmented generation (RAG) is key to enhancing large language models (LLMs) to systematically access richer factual knowledge. Yet, using RAG brings intrinsic challenges, as LLMs must deal with potentially conflicting knowledge,…

Computation and Language · Computer Science 2025-04-08 Leonardo Ranaldi , Federico Ranaldi , Fabio Massimo Zanzotto , Barry Haddow , Alexandra Birch

Large language models (LLMs) inevitably exhibit hallucinations since the accuracy of generated texts cannot be secured solely by the parametric knowledge they encapsulate. Although retrieval-augmented generation (RAG) is a practicable…

Computation and Language · Computer Science 2024-10-08 Shi-Qi Yan , Jia-Chen Gu , Yun Zhu , Zhen-Hua Ling

Recent development in Retrieval-Augmented Large Language Models (LLMs) have shown great promise in biomedical applications. How ever, a critical gap persists in reliably evaluating their curation ability the process by which models select…

Computation and Language · Computer Science 2025-08-07 Hanmeng Zhong , Linqing Chen , Wentao Wu , Weilei Wang

Agents capable of accomplishing complex tasks through multiple interactions with the environment have emerged as a popular research direction. However, in such multi-step settings, the conventional group-level policy optimization algorithm…

Machine Learning · Computer Science 2026-05-12 Leyang Shen , Yang Zhang , Chun Kai Ling , Xiaoyan Zhao , Tat-Seng Chua

Enabling large language models (LLMs) to appropriately abstain from answering questions beyond their knowledge is crucial for mitigating hallucinations. While existing reinforcement learning methods foster autonomous abstention, they often…

Machine Learning · Computer Science 2026-04-28 Cheng Gao , Cheng Huang , Kangyang Luo , Ziqing Qiao , Shuzheng Si , Huimin Chen , Chaojun Xiao , Maosong Sun

Retrieval-Augmented Generation (RAG) has significantly mitigated the hallucinations of Large Language Models (LLMs) by grounding the generation with external knowledge. Recent extensions of RAG to graph-based retrieval offer a promising…

Machine Learning · Computer Science 2025-09-23 Jialin Chen , Houyu Zhang , Seongjun Yun , Alejandro Mottini , Rex Ying , Xiang Song , Vassilis N. Ioannidis , Zheng Li , Qingjun Cui

Answering complex logical queries over large-scale knowledge graphs (KGs) represents an important artificial intelligence task, entailing a range of applications. Recently, knowledge representation learning (KRL) has emerged as the…

Cryptography and Security · Computer Science 2021-11-02 Zhaohan Xi , Ren Pang , Changjiang Li , Shouling Ji , Xiapu Luo , Xusheng Xiao , Ting Wang

In knowledge-intensive tasks, especially in high-stakes domains like medicine and law, it is critical not only to retrieve relevant information but also to provide causal reasoning and explainability. Large language models (LLMs) have…

Artificial Intelligence · Computer Science 2025-03-18 Hang Luo , Jian Zhang , Chujun Li

Large Language Models (LLMs) have been integrated into recommender systems to enhance user behavior comprehension. The Retrieval Augmented Generation (RAG) technique is further incorporated into these systems to retrieve more relevant items…

Information Retrieval · Computer Science 2025-03-27 Sichun Luo , Jian Xu , Xiaojie Zhang , Linrong Wang , Sicong Liu , Hanxu Hou , Linqi Song

Class-incremental learning (CIL) in medical image-guided diagnosis requires retaining prior diagnostic knowledge while adapting to newly emerging disease categories, which is critical for scalable clinical deployment. This problem is…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Xinyao Wu , Zhe Xu , Cheng Chen , Jiawei Ma , Yefeng Zheng , Raymond Kai-yu Tong

Recent large language model (LLM) reasoning, despite its success, suffers from limited domain knowledge, susceptibility to hallucinations, and constrained reasoning depth, particularly in small-scale models deployed in resource-constrained…

Artificial Intelligence · Computer Science 2025-03-04 Wenjie Wu , Yongcheng Jing , Yingjie Wang , Wenbin Hu , Dacheng Tao

Causal representation learning (CRL) offers the promise of uncovering the underlying causal model by which observed data was generated, but the practical applicability of existing methods remains limited by the strong assumptions required…

Machine Learning · Computer Science 2026-01-30 Yuhang Liu , Zhen Zhang , Dong Gong , Erdun Gao , Biwei Huang , Mingming Gong , Anton van den Hengel , Kun Zhang , Javen Qinfeng Shi