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Classification models that provide human-interpretable explanations enhance clinicians' trust and usability in medical image diagnosis. One research focus is the integration and prediction of pathology-related visual attributes used by…

Computer Vision and Pattern Recognition · Computer Science 2025-08-04 Luisa Gallée , Catharina Silvia Lisson , Christoph Gerhard Lisson , Daniela Drees , Felix Weig , Daniel Vogele , Meinrad Beer , Michael Götz

The field of explainable artificial intelligence (XAI) aims to uncover the inner workings of complex deep neural models. While being crucial for safety-critical domains, XAI inherently lacks ground-truth explanations, making its automatic…

Computer Vision and Pattern Recognition · Computer Science 2023-08-14 Robin Hesse , Simone Schaub-Meyer , Stefan Roth

To increase the transparency of modern computer-aided diagnosis (CAD) systems for assessing the malignancy of lung nodules, an interpretable model based on applying the generalized additive models and the concept-based learning is proposed.…

Image and Video Processing · Electrical Eng. & Systems 2024-05-29 Rinat I. Dumaev , Sergei A. Molodyakov , Lev V. Utkin

Feature-based self-explanatory methods explain their classification in terms of human-understandable features. In the medical imaging community, this semantic matching of clinical knowledge adds significantly to the trustworthiness of the…

Image and Video Processing · Electrical Eng. & Systems 2022-11-08 Jiahao Lu , Chong Yin , Oswin Krause , Kenny Erleben , Michael Bachmann Nielsen , Sune Darkner

Recently, Computer-Aided Diagnosis (CAD) systems have emerged as indispensable tools in clinical diagnostic workflows, significantly alleviating the burden on radiologists. Nevertheless, despite their integration into clinical settings, CAD…

Image and Video Processing · Electrical Eng. & Systems 2024-06-27 Muwei Jian , Hongyu Chen , Zaiyong Zhang , Nan Yang , Haorang Zhang , Lifu Ma , Wenjing Xu , Huixiang Zhi

Recent evolution in deep learning has proven its value for CT-based lung nodule classification. Most current techniques are intrinsically black-box systems, suffering from two generalizability issues in clinical practice. First,…

Image and Video Processing · Electrical Eng. & Systems 2022-02-28 Hanxiao Zhang , Liang Chen , Xiao Gu , Minghui Zhang , Yulei Qin , Feng Yao , Zhexin Wang , Yun Gu , Guang-Zhong Yang

Despite the recent successes of deep learning, such models are still far from some human abilities like learning from few examples, reasoning and explaining decisions. In this paper, we focus on organ annotation in medical images and we…

Computer Vision and Pattern Recognition · Computer Science 2020-01-01 Régis Pierrard , Jean-Philippe Poli , Céline Hudelot

Interpretability is essential in medical imaging to ensure that clinicians can comprehend and trust artificial intelligence models. In this paper, we propose a novel interpretable approach that combines attribute regularization of the…

Image and Video Processing · Electrical Eng. & Systems 2023-12-15 Maxime Di Folco , Cosmin I. Bercea , Julia A. Schnabel

Deep learning has now become the de facto approach to the recognition of anomalies in medical imaging. Their 'black box' way of classifying medical images into anomaly labels poses problems for their acceptance, particularly with…

Computer Vision and Pattern Recognition · Computer Science 2020-08-04 Satyananda Kashyap , Alexandros Karargyris , Joy Wu , Yaniv Gur , Arjun Sharma , Ken C. L. Wong , Mehdi Moradi , Tanveer Syeda-Mahmood

Ensuring transparency in machine learning decisions is critically important, especially in sensitive sectors such as healthcare, finance, and justice. Despite this, some popular explainable algorithms, such as Local Interpretable…

Machine Learning · Computer Science 2025-03-27 Shakiba Rahimiaghdam , Hande Alemdar

Due to the sensitive nature of medicine, it is particularly important and highly demanded that AI methods are explainable. This need has been recognised and there is great research interest in xAI solutions with medical applications.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Luisa Gallée , Catharina Silvia Lisson , Christoph Gerhard Lisson , Daniela Drees , Felix Weig , Daniel Vogele , Meinrad Beer , Michael Götz

Many rare genetic diseases exhibit recognizable facial phenotypes, which are often used as diagnostic clues. However, current facial phenotype diagnostic models, which are trained on image datasets, have high accuracy but often suffer from…

Quantitative Methods · Quantitative Biology 2025-04-21 Jie Song , Mengqiao He , Shumin Ren , Bairong Shen

Artificial intelligence (AI)-enabled diagnostics in maxillofacial pathology require structured, high-quality multimodal datasets. However, existing resources provide limited ameloblastoma coverage and lack the format consistency needed for…

Artificial Intelligence · Computer Science 2026-02-06 Ajo Babu George , Anna Mariam John , Athul Anoop , Balu Bhasuran

Machine learning models have utilized semantic features, deep features, or both to assess lung nodule malignancy. However, their reliance on manual annotation during inference, limited interpretability, and sensitivity to imaging variations…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Luoting Zhuang , Seyed Mohammad Hossein Tabatabaei , Ramin Salehi-Rad , Linh M. Tran , Denise R. Aberle , Ashley E. Prosper , William Hsu

Objective: Although medical imaging datasets are increasingly available, abnormal and annotation-intensive findings critical to lung cancer screening, particularly small pulmonary nodules, remain underrepresented and inconsistently curated.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Fakrul Islam Tushar , Ehsan Samei , Cynthia Rudin , Joseph Y. Lo

Machine learning approaches hold great potential for the automated detection of lung nodules in chest radiographs, but training the algorithms requires vary large amounts of manually annotated images, which are difficult to obtain. Weak…

The astounding success made by artificial intelligence (AI) in healthcare and other fields proves that AI can achieve human-like performance. However, success always comes with challenges. Deep learning algorithms are data-dependent and…

Image and Video Processing · Electrical Eng. & Systems 2021-06-25 Johann Li , Guangming Zhu , Cong Hua , Mingtao Feng , BasheerBennamoun , Ping Li , Xiaoyuan Lu , Juan Song , Peiyi Shen , Xu Xu , Lin Mei , Liang Zhang , Syed Afaq Ali Shah , Mohammed Bennamoun

Artificial intelligence (AI) continues to transform data analysis in many domains. Progress in each domain is driven by a growing body of annotated data, increased computational resources, and technological innovations. In medicine, the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Ahmad Chaddad , Qizong lu , Jiali Li , Yousef Katib , Reem Kateb , Camel Tanougast , Ahmed Bouridane , Ahmed Abdulkadir

Although machine learning (ML) models of AI achieve high performances in medicine, they are not free of errors. Empowering clinicians to identify incorrect model recommendations is crucial for engendering trust in medical AI. Explainable AI…

Artificial Intelligence · Computer Science 2022-12-20 Isil Guzey , Ozlem Ucar , Nukhet Aladag Ciftdemir , Betul Acunas

Machine learning models that offer excellent predictive performance often lack the interpretability necessary to support integrated human machine decision-making. In clinical medicine and other high-risk settings, domain experts may be…

Machine Learning · Computer Science 2021-04-19 Zach Wood-Doughty , Isabel Cachola , Mark Dredze
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