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DNA-based data storage systems face practical challenges due to the high cost of DNA synthesis. A strategy to address the problem entails encoding data via topological modifications of the DNA sugar-phosphate backbone. The DNA Punchcards…

Emerging Technologies · Computer Science 2025-05-07 Jin Sima , Chao Pan , S. Kasra Tabatabaei , Alvaro G. Hernandez , Charles M. Schroeder , Olgica Milenkovic

Deep neural networks have achieved strong performance in image classification tasks due to their ability to learn complex patterns from high-dimensional data. However, their large computational and memory requirements often limit deployment…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Sai Shi

Protection of the sensitive content is crucial for extensive information sharing. We present a technique of information concealing, based on introduction and maintenance of families of repeats. Repeats in DNA constitute a basic obstacle for…

Information Theory · Computer Science 2009-04-29 Lukas Kencl , Martin Loebl

We propose a new method for electrophoretic separation of DNA in which adsorbed polymers are driven over a disordered two-dimensional substrate which contains attractive sites for the polymers. Using simulations of a model for long polymer…

Soft Condensed Matter · Physics 2008-03-31 C. J. Olson Reichhardt , C. Reichhardt

Although the expenses associated with DNA sequencing have been rapidly decreasing, the current cost of sequencing information stands at roughly $120/GB, which is dramatically more expensive than reading from existing archival storage…

Discrete Mathematics · Computer Science 2023-11-30 Daniella Bar-Lev , Omer Sabary , Ryan Gabrys , Eitan Yaakobi

Motivated by mutation processes occurring in in-vivo DNA-storage applications, a channel that mutates stored strings by duplicating substrings as well as substituting symbols is studied. Two models of such a channel are considered: one in…

Information Theory · Computer Science 2020-07-01 Yuanyuan Tang , Yonatan Yehezkeally , Moshe Schwartz , Farzad Farnoud

Long-context DNA models are limited by token-mixing cost and by how compression allocates representational budget across the genome. Existing approaches operate close to base-pair resolution, apply fixed downsampling, or learn…

Genomics · Quantitative Biology 2026-05-13 Jianan Zhao , Xixian Liu , Zhihao Zhan , Xinyu Yuan , Hongyu Guo , Jian Tang

We introduce a novel method to analyse complete genomes and recognise some distinctive features by means of an adaptive compression algorithm, which is not DNA-oriented. We study the Information Content as a function of the number of…

Genomics · Quantitative Biology 2007-05-23 Giulia Menconi

The emerging field of DNA storage employs strands of DNA bases (A/T/C/G) as a storage medium for digital information to enable massive density and durability. The DNA storage pipeline includes: (1) encoding the raw data into sequences of…

Genomics · Quantitative Biology 2025-01-28 Hadas Abraham , Barak Gahtan , Adir Kobovich , Orian Leitersdorf , Alex M. Bronstein , Eitan Yaakobi

Emerging sonography techniques often require increasing the number of transducer elements involved in the imaging process. Consequently, larger amounts of data must be acquired and processed. The significant growth in the amounts of data…

Information Theory · Computer Science 2015-06-04 Noam Wagner , Yonina C. Eldar , Zvi Friedman

Encoding digital information into DNA sequences offers an attractive potential solution for storing rapidly growing data under the information age and the rise of artificial intelligence. However, practical implementations of DNA storage…

Information Theory · Computer Science 2026-01-26 Zimu Li , Bingyi Liu , Lei Zhao , Qian Zhang , Yang Liu , Jun Liu , Ke Ke , Huating Kong , Xiaolei Zuo , Chunhai Fan , Fei Wang

DNA has immense potential as an emerging data storage medium. The principle of DNA storage is the conversion and flow of digital information between binary code stream, quaternary base, and actual DNA fragments. This process will inevitably…

Information Retrieval · Computer Science 2022-10-21 Yun Qin , Fei Zhu , Bo Xi

In this paper, we study error exponents for a concatataned coding based class of DNA storage codes in which the number of reads performed can be variable. That is, the decoder can sequentially perform reads and choose whether to output the…

Information Theory · Computer Science 2025-04-25 Yan Hao Ling , Nir Weinberger , Jonathan Scarlett

DNA capture with high fidelity is an essential part of nanopore translocation. We report several important aspects of the capture process and subsequent translocation of a model DNA polymer through a solid-state nanopore in presence of an…

Soft Condensed Matter · Physics 2022-07-06 Swarnadeep Seth , Aniket Bhattacharya

DNA data storage is rapidly emerging as a promising solution for long-term data archiving, largely due to its exceptional durability. However, the synthesis of DNA strands remains a significant bottleneck in terms of cost and speed. To…

Other Computer Science · Computer Science 2025-07-11 Parv Agarwal , Nimesh Pinnamaneni , Thomas Heinis

Distributed training of deep neural networks has received significant research interest, and its major approaches include implementations on multiple GPUs and clusters. Parallelization can dramatically improve the efficiency of training…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-11-29 Jaehee Jang , Byungook Na , Sungroh Yoon

Recently, Transformer-based encoder-decoder models have demonstrated strong performance in multilingual speech recognition. However, the decoder's autoregressive nature and large size introduce significant bottlenecks during inference.…

Audio and Speech Processing · Electrical Eng. & Systems 2025-08-28 Yunkyu Lim , Jihwan Park , Hyung Yong Kim , Hanbin Lee , Byeong-Yeol Kim

RNA can be used as a high-density medium for data storage and transmission; however, an important RNA process -- replication -- is noisy. This paper presents an error analysis for RNA as a data transmission medium, analyzing how deletion…

Emerging Technologies · Computer Science 2016-09-26 Andrew W. Eckford , Taro Furbayashi , Tadashi Nakano

The coverage depth problem in DNA data storage is about minimizing the expected number of reads until all data is recovered. When they exist, MDS codes offer the best performance in this context. This paper focuses on the scenario where the…

Information Theory · Computer Science 2025-07-29 Matteo Bertuzzo , Alberto Ravagnani , Eitan Yaakobi

Recurrent neural networks have proved to be an effective method for statistical language modeling. However, in practice their memory and run-time complexity are usually too large to be implemented in real-time offline mobile applications.…

Computation and Language · Computer Science 2019-04-09 Artem M. Grachev , Dmitry I. Ignatov , Andrey V. Savchenko