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The optimal design of nanoparticle synthesis protocols is often achieved via one-at-a-time experimental designs. Aside from covering a limited space for the possible input conditions, these methods neglect possible interaction between…

Materials Science · Physics 2020-06-23 M. Reza. Andalibi , Paul Bowen , Agnese Carino , Andrea Testino

While the importance of automatic image analysis is continuously increasing, recent meta-research revealed major flaws with respect to algorithm validation. Performance metrics are particularly key for meaningful, objective, and transparent…

Image and Video Processing · Electrical Eng. & Systems 2023-12-08 Annika Reinke , Minu D. Tizabi , Carole H. Sudre , Matthias Eisenmann , Tim Rädsch , Michael Baumgartner , Laura Acion , Michela Antonelli , Tal Arbel , Spyridon Bakas , Peter Bankhead , Arriel Benis , Matthew Blaschko , Florian Buettner , M. Jorge Cardoso , Jianxu Chen , Veronika Cheplygina , Evangelia Christodoulou , Beth Cimini , Gary S. Collins , Sandy Engelhardt , Keyvan Farahani , Luciana Ferrer , Adrian Galdran , Bram van Ginneken , Ben Glocker , Patrick Godau , Robert Haase , Fred Hamprecht , Daniel A. Hashimoto , Doreen Heckmann-Nötzel , Peter Hirsch , Michael M. Hoffman , Merel Huisman , Fabian Isensee , Pierre Jannin , Charles E. Kahn , Dagmar Kainmueller , Bernhard Kainz , Alexandros Karargyris , Alan Karthikesalingam , A. Emre Kavur , Hannes Kenngott , Jens Kleesiek , Andreas Kleppe , Sven Kohler , Florian Kofler , Annette Kopp-Schneider , Thijs Kooi , Michal Kozubek , Anna Kreshuk , Tahsin Kurc , Bennett A. Landman , Geert Litjens , Amin Madani , Klaus Maier-Hein , Anne L. Martel , Peter Mattson , Erik Meijering , Bjoern Menze , David Moher , Karel G. M. Moons , Henning Müller , Brennan Nichyporuk , Felix Nickel , M. Alican Noyan , Jens Petersen , Gorkem Polat , Susanne M. Rafelski , Nasir Rajpoot , Mauricio Reyes , Nicola Rieke , Michael Riegler , Hassan Rivaz , Julio Saez-Rodriguez , Clara I. Sánchez , Julien Schroeter , Anindo Saha , M. Alper Selver , Lalith Sharan , Shravya Shetty , Maarten van Smeden , Bram Stieltjes , Ronald M. Summers , Abdel A. Taha , Aleksei Tiulpin , Sotirios A. Tsaftaris , Ben Van Calster , Gaël Varoquaux , Manuel Wiesenfarth , Ziv R. Yaniv , Paul Jäger , Lena Maier-Hein

Timely detection of abrupt anomalies is crucial for real-time monitoring and security of modern systems producing high-dimensional data. With this goal, we propose effective and scalable algorithms. Proposed algorithms are nonparametric as…

Machine Learning · Computer Science 2020-02-19 Mehmet Necip Kurt , Yasin Yilmaz , Xiaodong Wang

Machine learning (ML) and deep learning models are extensively used for parameter optimization and regression problems. However, not all inverse problems in ML are ``identifiable,'' indicating that model parameters may not be uniquely…

Machine Learning · Computer Science 2023-07-24 Reza Sameni

We develop a method for constructing tolerance bounds for functional data with random warping variability. In particular, we define a generative, probabilistic model for the amplitude and phase components of such observations, which…

Computation · Statistics 2019-07-24 J. Derek Tucker , John R. Lewis , Caleb King , Sebastian Kurtek

Dynamical systems, that are used to model power grids, the brain, and other physical systems, can exhibit coexisting stable states known as attractors. A powerful tool to understand such systems, as well as to better predict when they may…

Dynamical Systems · Mathematics 2023-07-31 George Datseris , Kalel Luiz Rossi , Alexandre Wagemakers

Given a segment of time series of a system at a particular set of parameter values, can one infers the global behavior of the system in its parameter space? Here we show that by using a learning machine we can achieve such a goal to a…

Adaptation and Self-Organizing Systems · Physics 2022-04-15 Hong Zhao

Observational studies provide invaluable opportunities to draw causal inference, but they may suffer from biases due to pretreatment difference between treated and control units. Matching is a popular approach to reduce observed covariate…

Methodology · Statistics 2025-09-17 Xinran Li

Researchers develop models to explain the unknowns. These models typically involve parameters that capture tangible quantities, the estimation of which is desired. Parameter identifiability investigates the recoverability of the unknown…

Optimization and Control · Mathematics 2024-07-01 Anuththara Sarathchandra , Azadeh Aghaeeyan , Pouria Ramazi

We consider the important problem of estimating parameter sensitivities for stochastic models of reaction networks that describe the dynamics as a continuous-time Markov process over a discrete lattice. These sensitivity values are useful…

Probability · Mathematics 2018-01-12 Ankit Gupta , Muruhan Rathinam , Mustafa Khammash

We consider the problem of estimating parameter sensitivity for Markovian models of reaction networks. Sensitivity values measure the responsiveness of an output to the model parameters. They help in analyzing the network, understanding its…

Probability · Mathematics 2014-04-18 Ankit Gupta , Mustafa Khammash

We propose and discuss sensitivity metrics for reliability analysis, which are based on the value of information. These metrics are easier to interpret than other existing sensitivity metrics in the context of a specific decision and they…

Optimization and Control · Mathematics 2021-12-03 Daniel Straub , Max Ehre , Iason Papaioannou

The sensitivity analysis and validation of simulation models require specific approaches in the case of spatial models. We describe the spatialdata scala library providing such tools, including synthetic generators for urban configurations…

Applications · Statistics 2020-07-22 Juste Raimbault , Julien Perret , Romain Reuillon

We consider the problem of active learning for global sensitivity analysis of expensive black-box functions. Our aim is to efficiently learn the importance of different input variables, e.g., in vehicle safety experimentation, we study the…

Machine Learning · Computer Science 2024-10-22 Syrine Belakaria , Benjamin Letham , Janardhan Rao Doppa , Barbara Engelhardt , Stefano Ermon , Eytan Bakshy

Estimating influential nodes in large scale networks including but not limited to social networks, biological networks, communication networks, emerging smart grids etc. is a topic of fundamental interest. To understand influences of nodes…

Social and Information Networks · Computer Science 2014-06-13 Sima Das

Global sensitivity analysis is a powerful set of ideas and heuristics for understanding the importance and interplay between uncertain parameters in a computational model. Such a model is characterized by a set of input parameters and an…

Numerical Analysis · Mathematics 2020-12-23 Chun Yui Wong , Pranay Seshadri , Geoffrey T. Parks

Image representations (artificial or biological) are often compared in terms of their global geometric structure; however, representations with similar global structure can have strikingly different local geometries. Here, we propose a…

Neurons and Cognition · Quantitative Biology 2025-05-19 Jenelle Feather , David Lipshutz , Sarah E. Harvey , Alex H. Williams , Eero P. Simoncelli

Sensitivity analysis (SA) has much to offer for a very large class of applications, such as model selection, calibration, optimization, quality assurance and many others. Sensitivity analysis offers crucial contextual information regarding…

When developing clinical prediction models, it can be challenging to balance between global models that are valid for all patients and personalized models tailored to individuals or potentially unknown subgroups. To aid such decisions, we…

In this paper, we introduce a general framework to quantify dissimilarities between generalized Lotka-Volterra dynamical processes, ranging from classical predator-prey systems to multispecies communities interacting on networks. The…

Statistical Mechanics · Physics 2025-11-18 Nicolás A. Márquez , Maryam Chaib De Mares , Alejandro P. Riascos