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A core challenge in structural biophysics is generating biomolecular conformations that are both physically plausible and consistent with experimental measurements. While sequence-to-structure diffusion models provide powerful priors,…

Machine Learning · Computer Science 2026-05-15 Minhuan Li , Jiequn Han , Pilar Cossio , Luhuan Wu

Diffusion-based image super-resolution (SR) methods have demonstrated remarkable performance. Recent advancements have introduced deterministic sampling processes that reduce inference from 15 iterative steps to a single step, thereby…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Zihang Liu , Zhenyu Zhang , Hao Tang

Deep neural networks ( DNNs ) are becoming a key enabling technology for many application domains. However, on-device inference on battery-powered, resource-constrained embedding systems is often infeasible due to prohibitively long…

Machine Learning · Computer Science 2019-11-13 Vicent Sanz Marco , Ben Taylor , Zheng Wang , Yehia Elkhatib

Stable diffusion models have ushered in a new era of advancements in image generation, currently reigning as the state-of-the-art approach, exhibiting unparalleled performance. The process of diffusion, accompanied by denoising through…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Andras Horvath

Detecting dynamic patterns of task-specific responses shared across heterogeneous datasets is an essential and challenging problem in many scientific applications in medical science and neuroscience. In our motivating example of rodent…

Neurons and Cognition · Quantitative Biology 2024-07-02 Yubai Yuan , Babak Shahbaba , Norbert Fortin , Keiland Cooper , Qing Nie , Annie Qu

Modeling the dynamics of cellular differentiation is fundamental to advancing the understanding and treatment of diseases associated with this process, such as cancer. With the rapid growth of single-cell datasets, this has also become a…

Cells use temporal dynamical patterns to transmit information via signaling pathways. As optimality with respect to the environment plays a fundamental role in biological systems, organisms have evolved optimal ways to transmit information.…

Biological Physics · Physics 2016-12-21 Yoshihiko Hasegawa

We proposed a novel approach to coherent imaging of dynamic samples. The inter-frame similarity of the sample's local structures is found to be a powerful constraint in phasing a sequence of diffraction patterns. We devised a new image…

Optics · Physics 2024-07-11 Pengju Sheng , Fucai Zhang

Monocular depth estimation involves predicting depth from a single RGB image and plays a crucial role in applications such as autonomous driving, robotic navigation, 3D reconstruction, etc. Recent advancements in learning-based methods have…

Computer Vision and Pattern Recognition · Computer Science 2025-02-05 Jingming Xia , Guanqun Cao , Guang Ma , Yiben Luo , Qinzhao Li , John Oyekan

Trajectory inference is a critical problem in single-cell transcriptomics, which aims to reconstruct the dynamic process underlying a population of cells from sequencing data. Of particular interest is the reconstruction of differentiation…

Genomics · Quantitative Biology 2026-04-06 Elodie Maignant , Tim Conrad , Christoph von Tycowicz

Current Deep Learning methods for environment segmentation and velocity estimation rely on Convolutional Recurrent Neural Networks to exploit spatio-temporal relationships within obtained sensor data. These approaches derive scene dynamics…

Computer Vision and Pattern Recognition · Computer Science 2023-06-21 Marco Braun , Moritz Luszek , Mirko Meuter , Dominic Spata , Kevin Kollek , Anton Kummert

Inferring cellular trajectories from destructive snapshots is complicated by the challenges of stochasticity and non-conservative mass dynamics such as cell proliferation and apoptosis. Existing unbalanced Optimal Transport (OT) methods…

Machine Learning · Computer Science 2026-05-04 Junda Ying , Yuxuan Wang , Bowen Yang , Peijie Zhou , Lei Zhang

The visualization of hierarchically structured data over time is an ongoing challenge and several approaches exist trying to solve it. Techniques such as animated or juxtaposed tree visualizations are not capable of providing a good…

Graphics · Computer Science 2020-02-11 Fabian Bolte , Mahsan Nourani , Eric D. Ragan , Stefan Bruckner

Super-resolution ultrasound via microbubble (MB) localisation and tracking, also known as ultrasound localisation microscopy (ULM), can resolve microvasculature beyond the acoustic diffraction limit. However, significant challenges remain…

As neural interfaces become more advanced, there has been an increase in the volume and complexity of neural data recordings. These interfaces capture rich information about neural dynamics that call for efficient, real-time processing…

Neural and Evolutionary Computing · Computer Science 2024-08-26 Sai Deepesh Pokala , Marie Bernert , Takuya Nanami , Takashi Kohno , Timothée Lévi , Blaise Yvert

Recent work has shown that convolutional neural networks (CNNs) can be applied successfully in disparity estimation, but these methods still suffer from errors in regions of low-texture, occlusions and reflections. Concurrently, deep…

Computer Vision and Pattern Recognition · Computer Science 2019-05-09 Junming Zhang , Katherine A. Skinner , Ram Vasudevan , Matthew Johnson-Roberson

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to study individual cellular distinctions and uncover unique cell characteristics. However, a significant technical challenge in scRNA-seq analysis is the occurrence of…

Genomics · Quantitative Biology 2024-07-25 Yoshitaka Inoue

Subsampling methods aim to select a subsample as a surrogate for the observed sample. Such methods have been used pervasively in large-scale data analytics, active learning, and privacy-preserving analysis in recent decades. Instead of…

Machine Learning · Statistics 2022-06-03 Jingyi Zhang , Cheng Meng , Jun Yu , Mengrui Zhang , Wenxuan Zhong , Ping Ma

Scanning Transmission Electron Microscopy (STEM) has become the main stay for materials characterization on atomic level, with applications ranging from visualization of localized and extended defects to mapping order parameter fields. In…

Instrumentation and Detectors · Physics 2019-01-15 Xin Li , Ondrej Dyck , Sergei V. Kalinin , Stephen Jesse

Contextually Entangled Gradient Mapping (CEGM) introduces a new approach to gradient optimization, redefining the relationship between contextual embeddings and gradient updates to enhance semantic coherence and reasoning capabilities in…

Machine Learning · Computer Science 2025-08-11 Colin Sisate , Alistair Goldfinch , Vincent Waterstone , Sebastian Kingsley , Mariana Blackthorn