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Objectives: We aim to quantify longitudinal acute kidney injury (AKI) trajectories and to describe transitions through progressing and recovery states and outcomes among hospitalized patients using multistate models. Methods: In this large,…

Quantitative Methods · Quantitative Biology 2023-03-13 Esra Adiyeke , Yuanfang Ren , Ziyuan Guan , Matthew M. Ruppert , Parisa Rashidi , Azra Bihorac , Tezcan Ozrazgat-Baslanti

The UK Biobank is collecting extensive data on health-related characteristics of over half a million volunteers. The biological samples of blood and urine can provide valuable insight on kidney function, with important links to…

Image and Video Processing · Electrical Eng. & Systems 2020-06-15 Taro Langner , Andreas Östling , Lukas Maldonis , Albin Karlsson , Daniel Olmo , Dag Lindgren , Andreas Wallin , Lowe Lundin , Robin Strand , Håkan Ahlström , Joel Kullberg

Acute Kidney Injury (AKI), a sudden decline in kidney function, is associated with increased mortality, morbidity, length of stay, and hospital cost. Since AKI is sometimes preventable, there is great interest in prediction. Most existing…

Machine Learning · Computer Science 2019-03-06 Samuel J. Weisenthal , Caroline Quill , Samir Farooq , Henry Kautz , Martin S. Zand

Contrastive pretraining provides robust representations by ensuring their invariance to different image transformations while simultaneously preventing representational collapse. Equivariant contrastive learning, on the other hand, provides…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 Taha Emre , Arunava Chakravarty , Dmitrii Lachinov , Antoine Rivail , Ursula Schmidt-Erfurth , Hrvoje Bogunović

Objective: Temporal electronic health records (EHRs) can be a wealth of information for secondary uses, such as clinical events prediction or chronic disease management. However, challenges exist for temporal data representation. We…

Machine Learning · Computer Science 2024-06-11 Feng Xie , Han Yuan , Yilin Ning , Marcus Eng Hock Ong , Mengling Feng , Wynne Hsu , Bibhas Chakraborty , Nan Liu

Chronic Kidney Disease (CKD) is an increasingly prevalent condition affecting 13% of the US population. The disease is often a silent condition, making its diagnosis challenging. Identifying CKD stages from standard office visit records can…

Quantitative Methods · Quantitative Biology 2017-12-07 M. Bhattacharya , C. Jurkovitz , H. Shatkay

ChronoMID builds on the success of cross-modal convolutional neural networks (X-CNNs), making the novel application of the technique to medical imaging data. Specifically, this paper presents and compares alternative approaches - timestamps…

Image and Video Processing · Electrical Eng. & Systems 2020-07-01 Alexander G. Rakowski , Petar Veličković , Enrico Dall'Ara , Pietro Liò

There is great interest in developing radiological classifiers for diagnosis, staging, and predictive modeling in progressive diseases such as Parkinson's disease (PD), a neurodegenerative disease that is difficult to detect in its early…

Chronic Kidney Disease (CKD), where delayed recognition implies premature mortality, is currently experiencing a globally increasing incidence and high cost to health systems. Data mining allows discovering subtle patterns in CKD indicators…

Machine Learning · Computer Science 2023-06-21 Pedro A. Moreno-Sanchez

Electronic Health Records (EHRs) have been heavily used to predict various downstream clinical tasks such as readmission or mortality. One of the modalities in EHRs, clinical notes, has not been fully explored for these tasks due to its…

Computation and Language · Computer Science 2019-06-05 Bonggun Shin , Julien Hogan , Andrew B. Adams , Raymond J. Lynch , Rachel E. Patzer , Jinho D. Choi

Deep neural Network (DNN) is becoming a focal point in Machine Learning research. Its application is penetrating into different fields and solving intricate and complex problems. DNN is now been applied in health image processing to detect…

Image and Video Processing · Electrical Eng. & Systems 2020-12-23 Iliyas Ibrahim Iliyas , Isah Rambo Saidu , Ali Baba Dauda , Suleiman Tasiu

Kidney abnormality segmentation has important potential to enhance the clinical workflow, especially in settings requiring quantitative assessments. Kidney volume could serve as an important biomarker for renal diseases, with changes in…

Hyperkinetic movement disorders (HMDs) in children, including dystonia (abnormal twisting) and chorea (irregular, random movements), pose significant diagnostic challenges due to overlapping clinical features. The prevalence of dystonia…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Nandika Ramamurthy , Dr Daniel Lumsden , Dr Rachel Sparks

Kidneys are the filter of the human body. About 10% of the global population is thought to be affected by Chronic Kidney Disease (CKD), which causes kidney function to decline. To protect in danger patients from additional kidney damage,…

The pressure in the renal interstitium is an important factor for normal kidney function. Here we develop a computational model of the rat kidney and use it to investigate the relationship between arterial blood pressure and interstitial…

Tissues and Organs · Quantitative Biology 2016-09-19 Mariel Bedell , Claire Yilin Lin , Emmie Roman-Melendez , Ioannis Sgouralis

In clinical trials where long follow-up is required to measure the primary outcome of interest, there is substantial interest in using an accepted surrogate outcome that can be measured earlier in time or with less cost to estimate a…

Methodology · Statistics 2024-12-19 Xuan Wang , Jie Zhou , Layla Parast , Tom Greene

Modelling disease progression of iron deficiency anaemia (IDA) following oral iron supplement prescriptions is a prerequisite for evaluating the cost-effectiveness of oral iron supplements. Electronic health records (EHRs) from the Clinical…

Applications · Statistics 2021-07-30 Li Su , Yafeng Cheng , Dora I. A. Pereira , Jonathan J. Powell

Disease progression modeling aims to characterize and predict how a patient's disease complications worsen over time based on longitudinal electronic health records (EHRs). For diseases such as type 2 diabetes, accurate progression modeling…

Artificial Intelligence · Computer Science 2026-03-31 Tingsong Xiao , Yao An Lee , Zelin Xu , Yupu Zhang , Zibo Liu , Yu Huang , Jiang Bian , Jingchuan Guo , Zhe Jiang

We address the problem of predicting when a disease will develop, i.e., medical event time (MET), from a patient's electronic health record (EHR). The MET of non-communicable diseases like diabetes is highly correlated to cumulative health…

Machine Learning · Computer Science 2023-06-01 Takayuki Katsuki , Kohei Miyaguchi , Akira Koseki , Toshiya Iwamori , Ryosuke Yanagiya , Atsushi Suzuki

The relationship between acute kidney injury (AKI) prediction and nephrotoxic drugs, or drugs that adversely affect kidney function, is one that has yet to be explored in the critical care setting. One contributing factor to this gap in…

Machine Learning · Computer Science 2024-01-10 Gabriel D. M. Manalu , Mulomba Mukendi Christian , Songhee You , Hyebong Choi