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Large language models (LLMs) offer new opportunities for constructing knowledge graphs (KGs) from unstructured clinical narratives. However, existing approaches often rely on structured inputs and lack robust validation of factual accuracy…

Artificial Intelligence · Computer Science 2026-01-06 Udiptaman Das , Krishnasai B. Atmakuri , Duy Ho , Chi Lee , Yugyung Lee

Large Language Models (LLMs) have significantly advanced medical question-answering by leveraging extensive clinical data and medical literature. However, the rapid evolution of medical knowledge and the labor-intensive process of manually…

Computation and Language · Computer Science 2025-07-01 Mohammad Reza Rezaei , Reza Saadati Fard , Jayson L. Parker , Rahul G. Krishnan , Milad Lankarany

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

Large language models (LLMs) have significantly advanced the field of natural language generation. However, they frequently generate unverified outputs, which compromises their reliability in critical applications. In this study, we propose…

Computation and Language · Computer Science 2025-02-18 Alexandru Lecu , Adrian Groza , Lezan Hawizy

Electronic Health Records (EHRs) and routine documentation practices play a vital role in patients' daily care, providing a holistic record of health, diagnoses, and treatment. However, complex and verbose EHR narratives overload healthcare…

Computation and Language · Computer Science 2025-02-26 Yanjun Gao , Ruizhe Li , Emma Croxford , John Caskey , Brian W Patterson , Matthew Churpek , Timothy Miller , Dmitriy Dligach , Majid Afshar

We introduce a novel graph-based Retrieval-Augmented Generation (RAG) framework specifically designed for the medical domain, called \textbf{MedGraphRAG}, aimed at enhancing Large Language Model (LLM) capabilities for generating…

Computer Vision and Pattern Recognition · Computer Science 2024-10-17 Junde Wu , Jiayuan Zhu , Yunli Qi , Jingkun Chen , Min Xu , Filippo Menolascina , Vicente Grau

Large language models (LLMs) are transforming the way information is retrieved with vast amounts of knowledge being summarized and presented via natural language conversations. Yet, LLMs are prone to highlight the most frequently seen…

Computation and Language · Computer Science 2024-02-20 Julien Delile , Srayanta Mukherjee , Anton Van Pamel , Leonid Zhukov

Large language models (LLMs) have demonstrated significant potential in clinical decision support. Yet LLMs still suffer from hallucinations and lack fine-grained contextual medical knowledge, limiting their high-stake healthcare…

Computation and Language · Computer Science 2025-04-22 Pengcheng Jiang , Cao Xiao , Minhao Jiang , Parminder Bhatia , Taha Kass-Hout , Jimeng Sun , Jiawei Han

Large language models (LLMs) have demonstrated remarkable capabilities in a wide range of tasks, yet their application to specialized domains remains challenging due to the need for deep expertise. Retrieval-Augmented generation (RAG) has…

Computation and Language · Computer Science 2025-09-30 Qinggang Zhang , Shengyuan Chen , Yuanchen Bei , Zheng Yuan , Huachi Zhou , Zijin Hong , Hao Chen , Yilin Xiao , Chuang Zhou , Junnan Dong , Yi Chang , Xiao Huang

Knowledge graphs and large language models (LLMs) are key tools for biomedical knowledge integration and reasoning, facilitating structured organization of scientific articles and discovery of complex semantic relationships. However,…

Computation and Language · Computer Science 2025-04-01 Yichun Feng , Jiawei Wang , Ruikun He , Lu Zhou , Yixue Li

Electronic Medical Records (EMRs), while integral to modern healthcare, present challenges for clinical reasoning and diagnosis due to their complexity and information redundancy. To address this, we proposed medIKAL (Integrating Knowledge…

Computation and Language · Computer Science 2025-02-18 Mingyi Jia , Junwen Duan , Yan Song , Jianxin Wang

Large Language Models (LLMs) have greatly contributed to the development of adaptive intelligent agents and are positioned as an important way to achieve Artificial General Intelligence (AGI). However, LLMs are prone to produce factually…

Computation and Language · Computer Science 2024-08-29 Weijian Xie , Xuefeng Liang , Yuhui Liu , Kaihua Ni , Hong Cheng , Zetian Hu

Large Language Models (LLMs) and Knowledge Graphs (KGs) offer a promising approach to robust and explainable Question Answering (QA). While LLMs excel at natural language understanding, they suffer from knowledge gaps and hallucinations.…

Machine Learning · Computer Science 2025-04-15 Jasper Linders , Jakub M. Tomczak

In today's rapidly evolving landscape of Artificial Intelligence, large language models (LLMs) have emerged as a vibrant research topic. LLMs find applications in various fields and contribute significantly. Despite their powerful language…

Computation and Language · Computer Science 2024-09-10 Tuan Bui , Oanh Tran , Phuong Nguyen , Bao Ho , Long Nguyen , Thang Bui , Tho Quan

This study applies Large Language Models (LLMs) to two foundational Electronic Health Record (EHR) data science tasks: structured data querying (using programmatic languages, Python/Pandas) and information extraction from unstructured…

Computation and Language · Computer Science 2026-01-29 Juan Jose Rubio Jan , Jack Wu , Julia Ive

Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

Retrieval-Augmented Generation (RAG) has emerged as a dominant paradigm for mitigating hallucinations in Large Language Models (LLMs) by incorporating external knowledge. Nevertheless, effectively integrating and interpreting key evidence…

Computation and Language · Computer Science 2026-01-26 Zhenghao Liu , Mingyan Wu , Xinze Li , Yukun Yan , Shuo Wang , Cheng Yang , Minghe Yu , Zheni Zeng , Maosong Sun

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

In recent years, Natural Language Processing (NLP) has played a significant role in various Artificial Intelligence (AI) applications such as chatbots, text generation, and language translation. The emergence of large language models (LLMs)…

Computation and Language · Computer Science 2024-07-10 Amanda Kau , Xuzeng He , Aishwarya Nambissan , Aland Astudillo , Hui Yin , Amir Aryani

In knowledge-intensive tasks, especially in high-stakes domains like medicine and law, it is critical not only to retrieve relevant information but also to provide causal reasoning and explainability. Large language models (LLMs) have…

Artificial Intelligence · Computer Science 2025-03-18 Hang Luo , Jian Zhang , Chujun Li
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