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The widespread application of large language models (LLMs) raises increasing demands on ensuring safety or imposing constraints, such as reducing harmful content and adhering to predefined rules. While there have been several works studying…

Machine Learning · Computer Science 2026-02-13 Yihan Du , Seo Taek Kong , R. Srikant

Large Language Models (LLMs) show promise for equation discovery, yet their outputs are highly sensitive to prompt phrasing, a phenomenon we term instruction brittleness. Static prompts cannot adapt to the evolving state of a multi-step…

Machine Learning · Computer Science 2026-01-05 Junqi Qu , Yan Zhang , Shangqian Gao , Shibo Li

In large language model (LLM)-based recommendation systems, direct preference optimization (DPO) effectively aligns recommendations with user preferences, requiring multi-negative objective functions to leverage abundant implicit-feedback…

Information Retrieval · Computer Science 2026-05-04 Xingyu Hu , Kai Zhang , Jiancan Wu , Shuli Wang , Chi Wang , Wenshuai Chen , Yinhua Zhu , Haitao Wang , Xingxing Wang , Xiang Wang

Varied approaches for aligning language models have been proposed, including supervised fine-tuning, RLHF, and direct optimization methods such as DPO. Although DPO has rapidly gained popularity due to its straightforward training process…

Computation and Language · Computer Science 2024-08-08 Prasann Singhal , Nathan Lambert , Scott Niekum , Tanya Goyal , Greg Durrett

The recent surge of versatile large language models (LLMs) largely depends on aligning increasingly capable foundation models with human intentions by preference learning, enhancing LLMs with excellent applicability and effectiveness in a…

Computation and Language · Computer Science 2024-06-19 Ruili Jiang , Kehai Chen , Xuefeng Bai , Zhixuan He , Juntao Li , Muyun Yang , Tiejun Zhao , Liqiang Nie , Min Zhang

Direct preference optimization (DPO) has shown success in aligning diffusion models with human preference. Previous approaches typically assume a consistent preference label between final generations and noisy samples at intermediate steps,…

Machine Learning · Computer Science 2025-02-05 Jie Ren , Yuhang Zhang , Dongrui Liu , Xiaopeng Zhang , Qi Tian

We propose Soft Preference Optimization (SPO), a method for aligning generative models, such as Large Language Models (LLMs), with human preferences, without the need for a reward model. SPO optimizes model outputs directly over a…

Machine Learning · Computer Science 2024-10-07 Arsalan Sharifnassab , Saber Salehkaleybar , Sina Ghiassian , Surya Kanoria , Dale Schuurmans

We present a three-stage framework for training deep learning models specializing in antibody sequence-structure co-design. We first pre-train a language model using millions of antibody sequence data. Then, we employ the learned…

Machine Learning · Computer Science 2025-10-24 Yibo Wen , Chenwei Xu , Jerry Yao-Chieh Hu , Kaize Ding , Han Liu

While astonishingly capable, large Language Models (LLM) can sometimes produce outputs that deviate from human expectations. Such deviations necessitate an alignment phase to prevent disseminating untruthful, toxic, or biased information.…

Artificial Intelligence · Computer Science 2024-10-30 Long Tan Le , Han Shu , Tung-Anh Nguyen , Choong Seon Hong , Nguyen H. Tran

As large language models (LLMs) become more capable, fine-tuning techniques for aligning with human intent are increasingly important. A key consideration for aligning these models is how to most effectively use human resources, or model…

Machine Learning · Computer Science 2024-07-01 William Muldrew , Peter Hayes , Mingtian Zhang , David Barber

Direct Preference Optimization (DPO) has emerged as a cornerstone of reinforcement learning from human feedback (RLHF) due to its simplicity and efficiency. However, existing DPO-based methods typically treat all preference pairs equally,…

Machine Learning · Computer Science 2026-05-26 Shangpin Peng , Weinong Wang , Zhuotao Tian , Senqiao Yang , Xing Wu , Haotian Xu , Chengquan Zhang , Takashi Isobe , Baotian Hu , Min Zhang

Direct Preference Optimization (DPO) aligns Large Language Models with human preferences without the need for a separate reward model. However, DPO treats all tokens in responses equally, neglecting the differing importance of individual…

Computation and Language · Computer Science 2026-05-27 Chengyu Huang , Zhuohang Li , Sheng-Yen Chou , Claire Cardie

Large language model reasoning is often treated as a monolithic capability, relying on binary preference supervision that fails to capture partial progress or fine-grained reasoning quality. We introduce Continuous Utility Direct Preference…

Preference-based reinforcement learning (RL) provides a framework to train agents using human preferences between two behaviors. However, preference-based RL has been challenging to scale since it requires a large amount of human feedback…

Machine Learning · Computer Science 2023-03-03 Changyeon Kim , Jongjin Park , Jinwoo Shin , Honglak Lee , Pieter Abbeel , Kimin Lee

The class of direct preference optimization (DPO) algorithms has emerged as a promising approach for solving the alignment problem in foundation models. These algorithms work with very limited feedback in the form of pairwise preferences…

Machine Learning · Computer Science 2026-02-03 Luca Viano , Ruida Zhou , Yifan Sun , Mahdi Namazifar , Volkan Cevher , Shoham Sabach , Mohammad Ghavamzadeh

Large Language Models (LLMs) have demonstrated remarkable potential in automating software development tasks. While recent advances leverage Supervised Fine-Tuning (SFT) and Direct Preference Optimization (DPO) to align models with human…

Software Engineering · Computer Science 2025-12-09 Xin Yin , Chao Ni , Xiaohu Yang

With the rapid advancement of large language models (LLMs), aligning policy models with human preferences has become increasingly critical. Direct Preference Optimization (DPO) has emerged as a promising approach for alignment, acting as an…

Artificial Intelligence · Computer Science 2025-07-15 Wenyi Xiao , Zechuan Wang , Leilei Gan , Shuai Zhao , Zongrui Li , Ruirui Lei , Wanggui He , Luu Anh Tuan , Long Chen , Hao Jiang , Zhou Zhao , Fei Wu

Large Protein Language Models have shown strong potential for generative protein design, yet they frequently produce structural hallucinations, generating sequences with high linguistic likelihood that fold into thermodynamically unstable…

Computation and Language · Computer Science 2026-01-05 QiWei Meng

Large language models are first pre-trained on trillions of tokens and then instruction-tuned or aligned to specific preferences. While pre-training remains out of reach for most researchers due to the compute required, fine-tuning has…

Computation and Language · Computer Science 2024-06-10 Megh Thakkar , Quentin Fournier , Matthew D Riemer , Pin-Yu Chen , Amal Zouaq , Payel Das , Sarath Chandar

Learning from nature has been a quest of humanity for millennia. While this has taken the form of humans assessing natural designs such as bones, butterfly wings, or spider webs, we can now achieve generating designs using advanced…

Materials Science · Physics 2023-01-18 Markus J. Buehler